Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS

NAEnrolling by invitationINTERVENTIONAL
Enrollment

196

Participants

Timeline

Start Date

March 4, 2019

Primary Completion Date

October 30, 2024

Study Completion Date

October 30, 2025

Conditions
PneumocystisHIV/AIDSSteroid
Interventions
DRUG

Conventional steroid regimen

Subjects will receive the conventional steroid regimen with prednisolone or equivalent (with methylprednisolone): Day 1 to 5: 40 mg orally every 12 h; Day 6 to 10: 40 orally every 24 hours; and Day 11 to 21: 20 mg orally every 24 h.

DRUG

Shortened steroid regimen

"* Subjects with Moderate PCP. Prednisolone (or equivalent with methylprednisolone) 40 mg orally every 12 h (Day 1 to 5);40 mg orally every 24 hours (Day 6 to 8).~* Subjects with severe PCP. Prednisolone (or equivalent with methylprednisolone) 40 mg orally every 12 h (Day 1 to 5),40 mg orally every 24 hours (Day 6 to 10); and 20 mg orally every 24 h (Day 11 to 14)."

Trial Locations (1)

14080

Centro de Investigacion en Enfermedades Infecciosas, México

All Listed Sponsors
lead

Centro de Investigación en. Enfermedades Infecciosas, Mexico

OTHER_GOV