Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery

PHASE2CompletedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

March 1, 2019

Primary Completion Date

October 12, 2019

Study Completion Date

October 12, 2019

Conditions
Monitored Anesthesia Care
Interventions
DRUG

Magnesium Sulphate

a loading of 50 mg/kg in 15 minutes of Magnesium sulphate, and will be followed by continuous infusion at 1 ml/kg/h of 15 mg/ml solution

DRUG

Fentanyl

loading of 1 mcg/kg in over 15 minutes of fentanyl then will receive continuous infusion starting at 1 ml /kg/h. of 0.5 mcg/ml solution

DRUG

Propofol

0.5-1.5 mg/kg bolus of propofol over 10 minutes to achieve target Ramsay sedation scale (RSS) of 3 (respond to command), if RSS afterwards does not reach 3 a supplementary bolus dose of 0.2 mg/kg propofol will be given to the patients, and will be followed by 1-2.5 mg/kg/hr infusion to maintain Intraoperative BIS readings between 60 - 80

Trial Locations (1)

11562

Kasr Alaini Hospital, Cairo

All Listed Sponsors
lead

Kasr El Aini Hospital

OTHER

NCT03854812 - Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery | Biotech Hunter | Biotech Hunter