Adjuvant Radiotherapy in Early Stage Oral Cancers

NAActive, not recruitingINTERVENTIONAL
Enrollment

392

Participants

Timeline

Start Date

August 2, 2018

Primary Completion Date

August 1, 2026

Study Completion Date

September 30, 2026

Conditions
Cancer of MouthCancer of the TongueCancer of the Head and NeckBuccal Mucosa CancerFloor of Mouth Carcinoma
Interventions
RADIATION

Post-operative adjuvant radiotherapy

"Conventional treatment planning, as well as intensity-modulated radiation therapy (IMRT) planning, would be allowed on the study with patients being stratified on the RT technique.~Treatment would be delivered on telecobalt unit (gamma-rays/linear accelerator (6MV photons). All fields would be treated daily.~Phase I: 46 Gray(Gy) in 23 fractions over 4.5 weeks Phase II: 14Gray in 7 fractions over 1.5 weeks~For IMRT, inverse planning would be done on a commercial TPS configured to deliver IMRT using 6MV photons. Patients shall be treated using the simultaneous integrated boost (SIB) technique with 5 fractions being delivered every week."

Trial Locations (8)

380006

HCG Hospital, Ahmedabad

391760

Kailash Cancer Hospital and Research Centre, Goraj

400012

Tata Memorial Centre, Mumbai

560004

Sree Sankara Cancer Hospital, Bangalore

560100

Mazumdar Shaw Medical Centre, Bangalore

670103

Malabar Cancer Centre, Kannur

682041

Amrita Institute of Medical Sciences, Kochi

781016

Dr. B Barooah Cancer Institute, Guwahati

All Listed Sponsors
collaborator

NATIONAL CANCER GRID

UNKNOWN

lead

Tata Memorial Hospital

OTHER_GOV

NCT03853655 - Adjuvant Radiotherapy in Early Stage Oral Cancers | Biotech Hunter | Biotech Hunter