A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

May 29, 2019

Primary Completion Date

February 16, 2023

Study Completion Date

February 16, 2023

Conditions
MelanomaCervical CarcinomaPancreatic CarcinomaTriple Negative Breast CancerHepatocellular CarcinomaUrothelial CarcinomaSquamous Cell Carcinoma of the Head and NeckNasopharyngeal CarcinomaRenal Cell CarcinomaNon-small Cell Lung CarcinomaSmall Cell Lung CarcinomaGastric or Gastroesophageal Junction AdenocarcinomaAdvanced or Metastatic Solid TumorsProstate CarcinomaEpithelial Ovarian CancerFallopian Tube CancerPrimary Peritoneal CarcinomaIntrahepatic CholangiocarcinomaSquamous Cell Anal CancerSquamous Cell Penile CarcinomaSquamous Cell Vulvar CarcinomaColorectal CarcinomaEndometrial Carcinoma
Interventions
BIOLOGICAL

XmAb®22841

Monoclonal bispecific antibody

BIOLOGICAL

Pembrolizumab (Keytruda®)

FDA-approved humanized monoclonal antibody

Trial Locations (28)

10016

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York

NYU Langone Medical Center (Tisch Hospital), New York

10032

Columbia University Medical Center, New York

15232

UPMC Hillman Cancer Center, Pittsburgh

UPMC Shadyside Hospital, Pittsburgh

19104

Hospital of the University of Pennsylvania - Perelman Center for Advanced Medicine, Philadelphia

30308

Emory University Hospital Midtown, Atlanta

30322

Winship Cancer Institute, Emory University, Atlanta

48109

University of Michigan Medical School, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

48334

Karmanos Cancer Institute Weisberg Cancer Treatment Center, Farmington Hills

52242

University of Iowa Hospital and Clinics, Iowa City

75230

Mary Crowley Cancer Research - Medical City, Dallas

77030

The University of Texas MD Anderson Cancer Center, Houston

84112

University of Utah, Huntsman Cancer Institute, Salt Lake City

90095

UCLA Hematology & Oncology Clinic, Los Angeles

92024

UCSD Medical Center - Encinitas, Encinitas

92037

Koman Family Outpatient Pavilion, La Jolla

UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion), La Jolla

UCSD Altman Clinical and Translational Research Institute Building (ACTRI), La Jolla

UCSD Perlman Medical Offices, La Jolla

92081

UCSD Medical Center - Vista, Vista

92093

UC San Diego Moores Cancer Center, La Jolla

92103

UC San Diego Medical Center - Hillcrest, San Diego

92127

UCSD Rancho Bernardo Medical Office, San Diego

02115

Brigham and Women's Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

02467

Brigham and Women's Health Care Center, Chestnut Hill, Chestnut Hill

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

ICON Clinical Research

INDUSTRY

lead

Xencor, Inc.

INDUSTRY