Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer (CHIPPI)

PHASE3RecruitingINTERVENTIONAL
Enrollment

362

Participants

Timeline

Start Date

April 1, 2019

Primary Completion Date

November 1, 2026

Study Completion Date

November 1, 2026

Conditions
Ovary NeoplasmsOvarian CancerOvarian Carcinoma
Interventions
DRUG

HIPEC

"HIPEC protocol (ONLY Arm A) consisted in cisplatin 100mg/m2 intraperitoneally (IP), heated to 40°C for 90 minutes, along with an IV perfusion of sodium thiosulfate.~Administration of the dose should be according the following schedule:~* 50% of the dose at start of perfusion, 25% of the dose after 30 minutes from start of the perfusion and 25% of the dose after 60 minutes from start of the perfusion.~* The procedure takes 120 minutes with a 90-minute perfusion period. The IV perfusion of sodium thiosulfate is for renal protection. At the start of HIPEC procedure, 9 g/m2 in 200 ml of distilled water will be administered by IV over 15 to 30 minutes. It will be then followed by 12 g/m2 in 1 liter (1L) distilled water in a continuous IV for 6 hours."

Trial Locations (18)

1070

RECRUITING

Institut Jules Bordet, Brussels

1200

RECRUITING

Cliniques universitaires St-Luc, Institut Roi Albert II, Brussels

13273

RECRUITING

Institut Paoli Calmettes, Marseille

14076

RECRUITING

Centre François Baclesse, Caen

33076

NOT_YET_RECRUITING

Institut Bergonié, Bordeaux

34298

RECRUITING

ICM-Val d'Aurelle, Montpellier

44800

WITHDRAWN

Institut de Cancérologie de l'Ouest, Saint-Herblain

49055

RECRUITING

Institut de Cancérologie de l'Ouest, Angers

54519

RECRUITING

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

59020

RECRUITING

Centre Oscar Lambret, Lille

59037

RECRUITING

Hôpital Jeanne de Flandre, Lille

63011

RECRUITING

Centre Jean Perrin, Clermont-Ferrand

69495

RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

75008

RECRUITING

Hôpital Européen Georges Pompidou, Paris

76100

RECRUITING

Clinique Mathilde, Rouen

94805

WITHDRAWN

Institut Gustave Roussy, Villejuif

Unknown

RECRUITING

Centre Henri Becquerel, Rouen

RECRUITING

Hôpital de Hautepierre, Strasbourg

All Listed Sponsors
lead

Centre Oscar Lambret

OTHER