Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV

PHASE2CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

May 6, 2019

Primary Completion Date

July 1, 2022

Study Completion Date

May 1, 2023

Conditions
HIV-1-infection
Interventions
DRUG

Saline

Placebo

DRUG

Lefitolimod

A TLR9 agonist administered s.c. once weekly for 8 weeks.

DRUG

3BNC117 and 10-1074

Broadly neutralizing antibodies against HIV env administered two times with a 3 week interval.

Trial Locations (8)

2100

Dept. of Infectious Diseases, Rigshospitalet, Copenhagen

2650

Dept. of Infectious Diseases, Amager and Hvidovre Hospitals, Hvidovre

5000

Dept. of Infectious Diseases, Odense University Hospital, Odense

8200

Dept. of Infectious Diseases, Aarhus University Hospital, Aarhus

9000

Dept. of Infectious Diseases, Aalborg University Hospital, Aalborg

84132

Dept. of Internal Medicine, University of Utah, Salt Lake City

Unknown

Alfred Hospital and Monash University, Melbourne

Oslo University Hospital, Oslo

All Listed Sponsors
collaborator

Aalborg University Hospital

OTHER

collaborator

Odense University Hospital

OTHER

collaborator

Rigshospitalet, Denmark

OTHER

collaborator

Hvidovre University Hospital

OTHER

collaborator

The Peter Doherty Institute for Infection and Immunity

OTHER

collaborator

University of Utah

OTHER

collaborator

Oslo University Hospital

OTHER

lead

University of Aarhus

OTHER

NCT03837756 - Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV | Biotech Hunter | Biotech Hunter