192
Participants
Start Date
March 24, 2019
Primary Completion Date
February 28, 2024
Study Completion Date
March 4, 2024
Liberal Red blood cell transfusion
"Hemoglobin level will be maintained above 9 g/dL (liberal strategy) for the first 48 hours following randomization. After 48 hours, indications of RBC transfusions will be at the discretion of attending physicians in patients with persistent circulatory failure.~After resolution of acute circulatory failure, a 7 g/dL transfusion threshold will be recommended regardless of the allocation arm. In case of subsequent episodes of septic shock, the transfusion strategy will be at the discretion of attending physicians"
Restrictive Red blood cell transfusion
Hemoglobin level will be maintained above 7 g/dL (restrictive strategy) during all the stay in ICU
Hopital Cochin AP-HP, Paris
CHU Amiens Picardie Site Sud, Amiens
Hopital Robert Ballanger, Aulnay-sous-Bois
Hopital Avicenne AP-HP, Bobigny
CH sud-Francilien, Corbeil
Hopital Henri Mondor AP-HP, Créteil
CHV André Mignot, Le Chesnay
Salengro, CHRU, Lille
CH Lyon Sud, Lyon
GH Édouard Herriot, Lyon
Institut Paoli Calmettes, Marseille
GH Sud Ile de France, Melun
Bel Air CHR, Metz
Mercy, CHR, Metz
CHU de Nantes, Nantes
La Source, CHR, Orléans
Hopital de La Pitié Salpetriere AP-HP, Paris
Hopital Saint Antoine AP-HP, Paris
Hopital Saint Louis AP-HP, Paris
Gustave Roussy, Villejuif
Assistance Publique - Hôpitaux de Paris
OTHER