Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

984

Participants

Timeline

Start Date

February 25, 2019

Primary Completion Date

January 31, 2027

Study Completion Date

January 31, 2027

Conditions
Chronic Lymphocytic Leukemia
Interventions
DRUG

Acalabrutinib

Acalabrutinib,

DRUG

Venetoclax

Venetoclax

DRUG

Chemoimmunotherapy

fludarabine/cyclophosphamide/rituximab (FCR), bendamustine/rituximab (BR)

DRUG

Obinutuzumab

Obinutuzumab

Trial Locations (170)

333

Research Site, Taoyuan

404

Research Site, Taichung

833

Research Site, Kaohsiung City

1083

Research Site, Budapest

1114

Research Site, Buenos Aires

1118

Research Site, Capital Federal

1125

Research Site, Budapest

1140

Research Site, Vienna

1606

Research Site, Sofia

2010

Research Site, Darlinghurst

2013

Research Site, Soweto

2100

Research Site, Copenhagen

2125

Research Site, Randburg

2217

Research Site, Kogarah

2298

Research Site, Waratah

3000

Research Site, Melbourne

Research Site, Vratsa

3084

Research Site, Heidelberg

3500

Research Site, Krems

4000

Research Site, Plovdiv

Research Site, Roskilde

4032

Research Site, Debrecen

4102

Research Site, Woolloongabba

5000

Research Site, Córdoba

Research Site, Adelaide

5020

Research Site, Salzburg

6009

Research Site, Nedlands

7400

Research Site, Kaposvár

7925

Research Site, Cape Town

8200

Research Site, Aarhus

9301

Research Site, Bloemfontein

10002

Research Site, Taipei

10021

Research Site, New York

10126

Research Site, Torino

11217

Research Site, Taipei

12713

Research Site, Riyadh

15224

Research Site, Pittsburgh

15232

Research Site, Pittsburgh

20132

Research Site, Milan

20162

Research Site, Milan

21201

Research Site, Baltimore

21423

Research Site, Jeddah

21565

Research Site, Incheon

28007

Research Site, Madrid

28031

Research Site, Madrid

28100

Research Site, Novara

28204

Research Site, Charlotte

28222

Research Site, Majadahonda

31059

Research Site, Toulouse

31444

Research Site, Dammam

31999

Research Site, Haifa

33098

Research Site, Paderborn

34090

Research Site, Montpellier

35033

Research Site, Rennes

35340

Research Site, Izmir

37007

Research Site, Salamanca

38280

Research Site, Talas

39008

Research Site, Santander

40207

Research Site, Louisville

41345

Research Site, Gothenburg

44718

Research Site, Canton

46009

Research Site, Valencia

46804

Research Site, Fort Wayne

47014

Research Site, Meldola

48121

Research Site, Ravenna

49100

Research Site, Petah Tikva

52620

Research Site, Tel Litwinsky

55139

Research Site, Kurupelit

64239

Research Site, Tel Aviv

67214

Research Site, Wichita

70056

Research Site, New Orleans

70185

Research Site, Örebro

70403

Research Site, Tainan City

70852

Research Site, Ostrava - Poruba

75013

Research Site, Paris

75015

Research Site, Paris

75185

Research Site, Uppsala

75475

Research Site, Paris

76038

Research Site, Rouen

78234

Research Site, Fort Sam Houston

83310

Research Site, Bratislava

90095

Research Site, Los Angeles

90277

Research Site, Redondo Beach

91120

Research Site, Jerusalem

94800

Research Site, Villejuif

97080

Research Site, Würzburg

98405

Research Site, Tacoma

99208

Research Site, Spokane

100034

Research Site, Beijing

100044

Research Site, Beijing

100191

Research Site, Beijing

110001

Research Site, Shenyang

110134

Research Site, Shenyang

115478

Research Site, Moscow

125284

Research Site, Moscow

130021

Research Site, Changchun

191024

Research Site, Saint Petersburg

197341

Research Site, Saint Petersburg

197347

Research Site, Saint Petersburg

210029

Research Site, Nanjing

300020

Research Site, Tianjin

300053

Research Site, Tula

310003

Research Site, Hangzhou

325000

Research Site, Wenzhou

330006

Research Site, Nanchang

354057

Research Site, Sochi

400037

Research Site, Chongqing

400138

Research Site, Volgograd

410008

Research Site, Changsha

430022

Research Site, Wuhan

430030

Research Site, Wuhan

443095

Research Site, Samara

450008

Research Site, Zhengzhou

450052

Research Site, Zhengzhou

510100

Research Site, Guangzhou

510515

Research Site, Guangzhou

610041

Research Site, Chengdu

710061

Research Site, Xi'an

830054

Research Site, Ürümqi

02215

Research Site, Boston

C1426ANZ

Research Site, Buenos Aires

74605-020

Research Site, Goiânia

90020-090

Research Site, Porto Alegre

90035-003

Research Site, Porto Alegre

90110-270

Research Site, Porto Alegre

20230-130

Research Site, Rio de Janeiro

22793-080

Research Site, Rio de Janeiro

01236-030

Research Site, São Paulo

01308-050

Research Site, São Paulo

05403-010

Research Site, São Paulo

T2N 5G2

Research Site, Calgary

T6G 1Z2

Research Site, Edmonton

V5Z 4E6

Research Site, Vancouver

K1H 8L6

Research Site, Ottawa

M4N 3M5

Research Site, Toronto

M5G 2M9

Research Site, Toronto

H4J 1C5

Research Site, Montreal

G1J 1Z4

Research Site, Québec

625 00

Research Site, Brno

500 05

Research Site, Hradec Králové

779 00

Research Site, Olomouc

304 60

Research Site, Plzen - Lochotin

Unknown

Research Site, Prague

Research Site, Jerusalem

Research Site, Ankara

5223 GZ

Research Site, 's-Hertogenbosch

1315 RA

Research Site, Almere Stad

1081 HV

Research Site, Amsterdam

6815 AD

Research Site, Arnhem

4818 CK

Research Site, Breda

36-200

Research Site, Brzozów

85-168

Research Site, Bydgoszcz

81-519

Research Site, Gdynia

30-727

Research Site, Krakow

93-510

Research Site, Lodz

20-081

Research Site, Lublin

50-367

Research Site, Wroclaw

50-556

Research Site, Wroclaw

0044

Research Site, Pretoria

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06591

Research Site, Seoul

08916

Research Site, Badalona

08035

Research Site, Barcelona

08041

Research Site, Barcelona

06100

Research Site, Ankara

CB2 0QQ

Research Site, Cambridge

CT1 3NG

Research Site, Canterbury

WV10 OQP

Research Site, Wolverhampton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Acerta Pharma BV

INDUSTRY