28
Participants
Start Date
April 18, 2019
Primary Completion Date
December 6, 2021
Study Completion Date
June 24, 2022
Serlopitant Tablet
Serlopitant is a small molecule, highly selective NK1-R (neurokinin-1 receptor) antagonist. Two critical mediators of the urge to scratch are Substance P, or SP, and its receptor, NK1-R. SP is a naturally occurring peptide in the tachykinin neuropeptide family. Tachykinins have a broad range of functions in the nervous and immune systems. SP binding of NK1-R has been shown to be a key mediator of sensory nerve signaling, including the itch-scratch reflex and the vomiting reflex.
Placebo Oral Tablet
The placebo is a tablet that looks like a drug but has no drug or other active ingredient in it.
Stanford University, Redwood City
Epidermolysis Bullosa Research Partnership
OTHER_GOV
Vyne Therapeutics Inc.
INDUSTRY
Stanford University
OTHER