Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-7339-010/KEYLYNK-010)

PHASE3CompletedINTERVENTIONAL
Enrollment

793

Participants

Timeline

Start Date

May 2, 2019

Primary Completion Date

March 14, 2022

Study Completion Date

January 27, 2024

Conditions
Prostatic Neoplasms
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Olaparib

Oral tablets

DRUG

Abiraterone acetate

Oral tablets

DRUG

Prednisone

Oral tablets

DRUG

Enzalutamide

Oral tablets or oral capsules

DRUG

Prednisolone

Oral tablets

Trial Locations (193)

407

Taichung Veterans General Hospital ( Site 0133), Taichung

704

National Cheng Kung University Hospital ( Site 0134), Tainen

1023

Auckland City Hospital ( Site 0193), Auckland

1090

Medizinische Universitaet Wien ( Site 0375), Vienna

2010

St. Vincent's Hospital ( Site 0158), Darlinghurst

2109

Macquarie University ( Site 0151), Macquarie University

2298

Calvary Mater Newcastle ( Site 0148), Waratah

2444

Port Macquarie Base Hospital ( Site 0153), Port Macquarie

2500

Southern Medical Day Care Centre ( Site 0160), Wollongong

3000

Peter MacCallum Cancer Centre ( Site 0152), Melbourne

3128

Box Hill Hospital ( Site 0146), Box Hill

4020

Ordensklinikum Linz GmbH Elisabethinen ( Site 0373), Linz

4029

Royal Brisbane and Women s Hospital ( Site 0155), Herston

4224

John Flynn Hospital & Medical Centre ( Site 0164), Tugun

5020

SCRI-CCCIT GesmbH ( Site 0371), Salzburg

6150

Fiona Stanley Hospital ( Site 0162), Murdoch

8036

Medizinische Universitat Graz ( Site 0374), Graz

10003

Hospital San Pedro de Alcantara ( Site 0326), Cáceres

10048

National Taiwan University Hospital ( Site 0131), Taipei

10117

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0301), Berlin

10408

National Cancer Center ( Site 0176), Goyang-si

11217

Taipei Veterans General Hospital ( Site 0135), Taipei

13009

Institut Paoli Calmettes ( Site 0419), Marseille

13210

Associated Medical Professionals of NY ( Site 0060), Syracuse

17007

Hospital Josep Trueta ( Site 0321), Girona

20016

Sibley Memorial Hospital ( Site 0096), Washington D.C.

20089

Istituto Clinico Humanitas Research Hospital ( Site 0452), Rozzano

21204

Chesapeake Urology Research Associates ( Site 0076), Towson

21287

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0005), Baltimore

23230

Virginia Cancer Institute ( Site 0052), Richmond

24014

Blue Ridge Cancer Care ( Site 0086), Roanoke

25000

CHU Jean Minjoz ( Site 0423), Besançon

27511

Duke Cancer Center Cary ( Site 0010), Cary

28223

Hospital Quiron Madrid ( Site 0325), Pozuelo de Alarcón

29016

Hospital Universitario Virgen de la Victoria ( Site 0337), Málaga

29200

CHU de Brest -Site Hopital Morvan ( Site 0441), Brest

29572

Carolina Urologic Research Center ( Site 0070), Myrtle Beach

30912

Georgia Cancer Center at Augusta University ( Site 0026), Augusta

31059

Institut Claudius Regaud IUCT Oncopole ( Site 0418), Toulouse

33076

Institut Bergonie ( Site 0421), Bordeaux

34298

Institut Regional du Cancer de Montpellier - ICM ( Site 0443), Montpellier

38122

Presidio Ospedaliero Santa Chiara ( Site 0451), Trento

40138

Policlinico S.Orsola-Malpighi ( Site 0453), Bologna

40225

Universitaetsklinikum Duesseldorf ( Site 0306), Düsseldorf

40447

China Medical University Hospital ( Site 0132), Taichung

44106

University Hospitals of Cleveland Seidman Cancer Center ( Site 0036), Cleveland

44718

Gabrail Cancer Center-Research ( Site 0097), Canton

44805

Institut De Cancerologie De L Ouest ( Site 0448), Saint-Herblain

45100

Centre Hospitalier Regional du Orleans ( Site 0430), Orléans

45212

The Urology Group- Cincinnati ( Site 0094), Cincinnati

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0462), Meldola

48201

Barbara Ann Karmanos Cancer Institute ( Site 0077), Detroit

48202

Henry Ford Health System ( Site 0039), Detroit

52100

Medical Oncology Ospedale San Donato ( Site 0461), Arezzo

53226

Froedtert and Medical College of Wisconsin ( Site 0045), Milwaukee

54100

Centre D Oncologie de Gentilly ( Site 0432), Nancy

54292

Krankenhaus der Barmherzigen Brueder Trier ( Site 0310), Trier

58128

Chonnam National University Hwasun Hospital ( Site 0174), Hwasun Gun

59102

St. Vincent Frontier Cancer Center ( Site 0016), Billings

62301

Quincy Medical Group ( Site 0021), Quincy

63011

Centre Jean Perrin ( Site 0434), Clermont-Ferrand

67000

Clinique Sainte Anne ( Site 0431), Strasbourg

68130

Nebraska Cancer Specialists ( Site 0034), Omaha

68167

Universitaetsklinikum in Mannheim ( Site 0314), Mannheim

69310

C.H.U. Lyon Sud ( Site 0436), Pierre-Bénite

69373

Centre Leon Berard ( Site 0422), Lyon

70112

Tulane Cancer Center ( Site 0066), New Orleans

72076

Universitaetsklinik fuer Urologie ( Site 0307), Tübingen

72622

Studienpraxis Urologie ( Site 0309), Nürtingen

75014

Institut Mutualiste Montsouris ( Site 0446), Paris

79106

Universitaetsklinikum Freiburg - Medizinische Klinik ( Site 0304), Freiburg im Breisgau

80000

CHU Amiens Picardie Site Sud Amiens ( Site 0438), Amiens

81675

Klinikum Rechts der Isar ( Site 0300), Munich

84000

Institut Sainte Catherine ( Site 0447), Avignon

84112

Huntsman Cancer Institute ( Site 0002), Salt Lake City

87131

University of New Mexico Cancer Center ( Site 0048), Albuquerque

88011

Memorial Medical Center ( Site 0095), Las Cruces

89169

Comprehensive Cancer Centers of Nevada ( Site 0092), Las Vegas

90404

UCLA Hematology/Oncology - Santa Monica ( Site 0081), Los Angeles

90419

Universitaetsklinik der Paracelsus Medizinischen Privatuniversitaet ( Site 0318), Nuremberg

91054

Universitaetsklinikum Erlangen ( Site 0303), Erlangen

92150

Hopital Foch ( Site 0428), Suresnes

92835

St. Joseph Heritage Healthcare ( Site 0069), Fullerton

94800

Institut Gustave Roussy ( Site 0416), Villejuif

95126

Azienda Ospedaliera Cannizzaro ( Site 0458), Catania

98109

Seattle Cancer Care Alliance ( Site 0079), Seattle

117997

Russian Scientific Center of Roentgenoradiology ( Site 0559), Moscow

121359

Central Clinical Hospital with Polyclinic ( Site 0562), Moscow

191104

SBHI Leningrad Regional Oncology Dispensary ( Site 0588), Saint Petersburg

197758

Clinical Research Center of specialized types medical care-Oncology ( Site 0570), Saint Petersburg

Russian Scientific Center of Radiology and Surgical Technologies ( Site 0567), Saint Petersburg

443031

SBHI Samara Regional Clinical Oncology Dispensary ( Site 0576), Samara

454087

Chelyabinsk Regional Clinical Oncological Dispensary ( Site 0565), Chelyabinsk

634028

Tomsk National Scientific Medical Center of Russian Academy of Science ( Site 0579), Tomsk

644013

Omsk Clinical Oncology Dispensary ( Site 0568), Omsk

660133

Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0585), Krasnoyarsk

1834111

Ha Emek Medical Center ( Site 0548), Afula

3109601

Rambam Medical Center ( Site 0543), Haifa

4428164

Meir Medical Center ( Site 0544), Kfar Saba

4780000

Centro Investigación del Cáncer James Lind ( Site 1041), Temuco

4810148

Rey y Oreilly Limitada ( Site 1048), Temuco

4941492

Rabin Medical Center ( Site 0545), Petah Tikva

5262000

Chaim Sheba Medical Center ( Site 0541), Ramat Gan

6423906

Sourasky Medical Center ( Site 0542), Tel Aviv

7030001

Assaf Harofe ( Site 0547), Be’er Ya‘aqov

7500921

Fundacion Arturo Lopez Perez ( Site 1049), Santiago

8330032

Pontificia Universidad Catolica de Chile ( Site 1047), Santiago

8410101

Soroka Medical Center ( Site 0549), Beersheba

8420383

Bradford Hill Centro de Investigaciones Clinicas ( Site 1044), Santiago

9112001

Hadassah Ein Kerem Medical Center ( Site 0546), Jerusalem

02215

Beth Israel Deaconess Medical Ctr. ( Site 0093), Boston

Dana Farber Cancer Institute ( Site 0033), Boston

01655

UMass Memorial Medical Center ( Site 0053), Worcester

B1884BBF

Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 1013), Berazategui

C1120AAT

Centro de Diagnostico Urologico ( Site 1008), Buenos Aires

C1280AEB

Hospital Britanico de Buenos Aires ( Site 1006), Buenos Aires

S2000DSV

Sanatorio Parque ( Site 1002), Rosario

C1012AAR

Instituto de Investigaciones Metabolicas ( Site 1011), Buenos Aires

C1118AAT

Hospital Aleman ( Site 1004), Buenos Aires

C1426ANZ

Instituto Medico Alexander Fleming ( Site 1010), Buenos Aires

X5008HHW

CEMAIC ( Site 1014), Córdoba

98700-000

Hospital de Caridade de Ijui ( Site 1038), Ijuí

90610-000

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 1021), Porto Alegre

88301-215

Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1035), Itajaí

15090-000

Hospital de Base de Sao Jose de Rio Preto ( Site 1022), São José do Rio Preto

04014-002

IBCC - Instituto Brasileiro de Controle do Câncer ( Site 1040), São Paulo

01509-900

A.C. Camargo Cancer Center ( Site 1026), São Paulo

T6G 1Z2

Cross Cancer Institute ( Site 0110), Edmonton

V1Y 5L3

BC Cancer-Kelowna - Sindi Ahluwalia Hawkins Centre ( Site 0113), Kelowna

V5Z 4E6

BC Cancer-Vancouver Center ( Site 0112), Vancouver

B3H 2Y9

Nova Scotia Health Authority QEII-HSC ( Site 0114), Halifax

L6R 3J7

William Osler Health System (Brampton Civic Hospital) ( Site 0121), Brampton

L8V 5C2

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0116), Hamilton

M5G 2M9

Princess Margaret Cancer Centre ( Site 0107), Toronto

G1R 2J6

CHUQ-Univ Laval-Hotel Dieu de Quebec ( Site 0103), Québec

G5L 5T1

CIUSSS du Bas Saint Laurent - Hopital Regional de Rimouski ( Site 0102), Rimouski

J1H 5N4

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0105), Sherbrooke

02321

C.H. de Saint Quentin ( Site 0481), Saint-Quentin

07747

Universitaetsklinikum Jena ( Site 0305), Jena

D24 NROA

Tallaght University Hospital ( Site 0730), Dublin

Unknown

Mid Western Cancer Centre ( Site 0728), Limerick

00152

Azienda Ospedaliera San Camillo Forlanini ( Site 0455), Roma

00168

Fondazione Policlinico Universitario A. Gemelli ( Site 0463), Roma

05100

Azienda Ospedaliera Santa Maria Terni ( Site 0456), Terni

470-1192

Fujita Health University Hospital ( Site 0724), Toyoake

277-8577

National Cancer Center Hospital East ( Site 0702), Kashiwa

285-8741

Toho University Sakura Medical Center ( Site 0703), Sakura

791-0280

National Hospital Organization Shikoku Cancer Center ( Site 0716), Matsuyama

650-0047

Kobe City Medical Center General Hospital ( Site 0726), Kobe

920-8641

Kanazawa University Hospital ( Site 0701), Kanazawa

252-0375

Kitasato University Hospital ( Site 0705), Sagamihara

232-0024

Yokohama City University Medical Center ( Site 0706), Yokohama

634-8522

Nara Medical University Hospital ( Site 0715), Kashihara

589-8511

Kindai University Hospital ( Site 0714), Sayama

565-0871

Osaka University Hospital ( Site 0713), Suita

350-1298

Saitama Medical University International Medical Center ( Site 0708), Hidaka

343-8555

Dokkyo Medical University Saitama Medical Center ( Site 0707), Koshigaya

417-8567

Fuji City General Hospital ( Site 0725), Fuji

431-3192

Hamamatsu University Hospital ( Site 0720), Hamamatsu

755-8505

Yamaguchi University Hospital ( Site 0717), Ube

260-8717

Chiba Cancer Center ( Site 0704), Chiba

812-8582

Kyushu University Hospital ( Site 0718), Fukuoka

889-1692

University of Miyazaki Hospital ( Site 0721), Miyazaki

381-8551

Nagano Municipal Hospital ( Site 0723), Nagano

852-8501

Nagasaki University Hospital ( Site 0719), Nagasaki

541-8567

Osaka International Cancer Institute ( Site 0722), Osaka

105-8470

Toranomon Hospital ( Site 0711), Tokyo

113-8603

Nippon Medical School Hospital ( Site 0709), Tokyo

160-8582

Keio University Hospital ( Site 0710), Tokyo

6525 GA

Radboud University Medical Center ( Site 0470), Nijmegen

1066 CX

Antoni van Leeuwenhoek Ziekenhuis ( Site 0480), Amsterdam

1081 HV

Vrije Universiteit Medisch Centrum ( Site 0479), Amsterdam

2134 TM

Spaarne Ziekenhuis ( Site 0473), Hoofddorp

7555 DL

Ziekenhuisgroep Twente ( Site 0469), Hengelo

8934 AD

Medisch Centrum Leeuwarden ( Site 0477), Leeuwarden

2262 BA

Haaglanden MC - locatie Antoniushove ( Site 0471), Leidschendam

3015 GD

Erasmus MC ( Site 0475), Rotterdam

3118 JH

Franciscus Gasthuis en Vlietland ( Site 0489), Schiedam

05505

Asan Medical Center ( Site 0171), Songpagu

03722

Severance Hospital Yonsei University Health System ( Site 0173), Seoul

06351

Samsung Medical Center ( Site 0172), Seoul

08908

Instituto Catalan de Oncologia - ICO ( Site 0330), L'Hospitalet de Llobregat

08208

Hospital Parc Tauli ( Site 0335), Sabadell

08003

Hospital del Mar ( Site 0333), Barcelona

08035

Hospital General Universitari Vall d Hebron ( Site 0334), Barcelona

08036

Hospital Clinic ( Site 0323), Barcelona

BS2 8ED

University Hospitals Bristol NHS Foundation Trust ( Site 0530), Bristol

CB2 0QQ

Cambridge University Hospitals NHS Trust ( Site 0540), Cambridge

TQ2 7AA

Torbay Hospital ( Site 0532), Torquay

SM2 5PT

Royal Marsden Hospital ( Site 0526), Sutton

TA1 5DA

Musgrove Park Hospital ( Site 0537), Taunton

ST4 6QG

University of North Midlands NHS Foundation Trust ( Site 0527), Stoke-on-Trent

HA6 2RN

Mount Vernon Cancer Centre ( Site 0536), Northwood

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03834519 - Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-7339-010/KEYLYNK-010) | Biotech Hunter | Biotech Hunter