Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

450

Participants

Timeline

Start Date

April 1, 2019

Primary Completion Date

June 28, 2024

Study Completion Date

December 22, 2025

Conditions
Carcinoma, Squamous Cell
Interventions
BIOLOGICAL

Pembrolizumab

400 mg IV infusion

DRUG

Placebo

Placebo-matched IV infusion

Trial Locations (181)

1083

Semmelweis Egyetem ( Site 0507), Budapest

1115

Szent Imre Egyetemi Oktatokorhaz ( Site 0502), Budapest

2050

Chris OBrien Lifehouse ( Site 0051), Camperdown

2065

Royal North Shore Hospital ( Site 0052), St Leonards

2480

Lismore Base Hospital ( Site 0050), Lismore

2800

Orange Health Services ( Site 0053), Orange

3004

Alfred Health ( Site 0055), Melbourne

4032

Debreceni Egyetem. ( Site 0506), Debrecen

4215

Gold Coast University Hospital ( Site 0054), Southport

4400

Szabolcs Szatmar Bereg Megyei Korhazak es Egyetemi Oktatokorhaz ( Site 0500), Nyíregyháza

4575

Sunshine Coast University Private Hospital-Coastal Cancer Care ( Site 0056), Sunshine Coast

5021

Haukeland sykehus ( Site 0851), Bergen

6720

Szegedi Tudomanyegyetem ( Site 0504), Szeged

7030

St. Olavs Hospital HF ( Site 0852), Trondheim

7632

Pecsi Tudomanyegyetem AOK ( Site 0501), Pécs

10029

Icahn School of Medicine at Mount Sinai ( Site 1575), New York

10117

Universitaetsklinikum Berlin - Charite - Campus Mitte ( Site 0400), Berlin

11042

Northwell Health/ RJ Zuckerberg Cancer Center-Medical Oncology ( Site 1565), Lake Success

13285

Hopital Saint Joseph ( Site 0376), Marseille

13385

Hopital La Timone ( Site 0353), Marseille

14000

Centre Hospitalier Universitaire de Caen Normandie-DERMATOLOGY ( Site 0365), Caen

15232

UPMC Hillman Cancer Center ( Site 1570), Pittsburgh

20014

Onkologikoa - Instituto Oncologico de San Sebastian ( Site 1258), Doniostia - San Sebastian

20133

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 0600), Milan

20141

Istituto Europeo di Oncologia ( Site 0602), Milan

20246

Universitaetsklinikum Hamburg-Eppendorf ( Site 0414), Hamburg

21614

Elbe Kliniken Stade-Buxtehude, Klinikum Buxtehude-Dermatologisches Zentrum ( Site 0411), Buxtehude

22031

Inova Schar Cancer Institute ( Site 1538), Fairfax

25011

Limited Liability Company Ukrainian Center of Tomotherapy-Department of Chemotherapy ( Site 1451), Kropyvnytskyi

25030

CHU Besancon - Hopital Jean Minjoz ( Site 0359), Besançon

26506

West Virginia University ( Site 1569), Morgantown

26953

Centre Hospitalier de Valence ( Site 0377), Valence

27000

Cimab SA de CV ( Site 0708), Torreón

27010

Centro de Investigación Clínica de Alta Especialidad ( Site 0715), Torreón

28034

Hospital Universitario Ramon y Cajal ( Site 1251), Madrid

29010

Hospital Universitario Carlos Haya ( Site 1255), Málaga

29090

San Lucas Cardiologica del Sureste S.A de C.V. ( Site 0722), Tuxtla Gutiérrez

29425

MUSC Hollings Cancer Center ( Site 1533), Charleston

30029

C.H.U. de Nimes. Hopital Caremeau ( Site 0368), Nîmes

30625

Medizinische Hochschule Hannover ( Site 0405), Hanover

31000

Centro Estatal de Cancerologia de Chihuahua ( Site 0703), Chihuahua City

31059

Institut Claudius Regaud IUCT Oncopole ( Site 0354), Toulouse

32608

UF Health ( Site 1511), Gainesville

33075

CHU de Bordeaux- Hopital Saint Andre ( Site 0370), Bordeaux

33136

University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 1544), Miami

33486

Boca Raton Regional Hospital ( Site 1551), Boca Raton

34295

CHU Montpellier. ( Site 0367), Montpellier

35043

Universitatsklinikum Giessen und Marburg GmbH ( Site 0413), Marburg

36604

University of South Alabama, Mitchell Cancer Institute ( Site 1562), Mobile

37232

Vanderbilt Ingram Cancer Center ( Site 1543), Nashville

38138

West Cancer Center - East Campus ( Site 1535), Germantown

39008

Hospital Universitario Marques de Valdecilla ( Site 1256), Santander

40022

Sumy regional clinical oncological dispensary-Oncothoracic department ( Site 1452), Sumy

40536

University of Kentucky School of Medicine & Hospitals ( Site 1542), Lexington

44195

Cleveland Clinic ( Site 1541), Cleveland

44260

Onco-Hematologia de Occidente ( Site 0716), Guadalajara

44349

Hospital de Especialidades Centro Medico de Occidente ( Site 0704), Guadalajara

44680

Consultorios de Medicina Especializada del Sector Privado ( Site 0701), Guadalajara

45147

Universitaetsklinikum Essen ( Site 0403), Essen

46202

Indiana University Melvin and Bren Simon Cancer Center ( Site 1515), Indianapolis

52242

University of Iowa Hospital and Clinics ( Site 1514), Iowa City

56126

Azienda Ospedaliero Universitaria Pisana ( Site 0603), Pisa

59037

CHRU de Lille - Hopital Claude Huriez ( Site 0355), Lille

61103

Institute of General and Emergency Surgery named after V.T. Zaitsev NAMS of Ukraine ( Site 1450), Kharkiv

63003

CHU Estaing ( Site 0360), Clermont-Ferrand

68017

Fundación Cardiovascular de Colombia ( Site 0207), Piedecuesta

69495

CH Lyon Sud Hospices Civils de Lyon ( Site 0350), Pierre-Bénite

70124

Instituto Tumori Giovanni Paolo II ( Site 0604), Bari

72076

Universitaetsklinikum Tuebingen ( Site 0409), Tübingen

74374

Centre Hospitalier Annecy Genevois ( Site 0361), Pringy

76018

"Communal Non-Commercial Enterprise Prykarpatski Clinical On-Department for daily treated patient (", Ivano-Frankivsk

77030

The University of Texas-MD Anderson Cancer Center ( Site 1536), Houston

80045

University of Colorado Cancer Center ( Site 1506), Aurora

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 0601), Napoli

84112

Huntsman Cancer Institute ( Site 1537), Salt Lake City

86021

CHU Poitiers ( Site 0375), Poitiers

90095

UCLA Hematology/Oncology - Westwood (Building 100) ( Site 1568), Los Angeles

90419

Klinikum Nürnberg Nord ( Site 0415), Nuremberg

91010

City of Hope Medical Center ( Site 1505), Duarte

91900

FAICIC Clinical Research ( Site 0700), Veracruz

93009

Hopital Avicenne ( Site 0358), Bobigny

94305

Stanford University Medical Center ( Site 1503), Stanford

94800

Institut Gustave Roussy ( Site 0352), Villejuif

95817

University of California Davis Comprehensive Cancer Center ( Site 1560), Sacramento

97134

Centro de atencion e investigacion clinica en oncologia ( Site 0706), Mérida

97213

Providence Portland Medical Center ( Site 1530), Portland

111411

Sociedad de Cirugía de Bogotá - Hospital de San Jose ( Site 0201), Bogotá

111511

Instituto Nacional de Cancerologia E.S.E ( Site 0204), Bogotá

115478

N.N. Blokhin NMRCO ( Site 1153), Moscow

115682

FSCC FMBA of Russia ( Site 1163), Moscow

119991

First Moscow State Medical University n.a. I.M.Sechenov ( Site 1164), Moscow

121205

Hadassah Medical-Oncology department ( Site 1173), Moscow

150054

Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1152), Yaroslavl

195271

Railway Hospital of OJSC ( Site 1161), Saint Petersburg

200347

S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 1101), Craiova

230002

Oncomedica S.A. ( Site 0205), Montería

249036

A. Tsyb Medical Radiological Research Center - branch of the National Medical Research Radiological, Obninsk

300166

S C Oncocenter Oncologie Medicala S R L ( Site 1106), Timișoara

300239

Policlinica Oncomed SRL ( Site 1105), Timișoara

354057

Oncological Dispensary #2 of Ministry of Health of Krasnodar region ( Site 1159), Sochi

400015

Cardiomed SRL Cluj-Napoca ( Site 1104), Cluj-Napoca

Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 1113), Cluj-Napoca

Spitalul Universitar CF Cluj-Napoca ( Site 1103), Cluj-Napoca

410469

S C Pelican Impex SRL ( Site 1108), Oradea

426009

Udmurtia Republic Regional Clinical Oncology Dispensary ( Site 1158), Izhevsk

450054

GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 1171), Ufa

603126

Nizhniy Novgorod regional clinical oncological dispensary ( Site 1169), Nizhny Novgorod

656045

Altay Regional Oncology Dispensary ( Site 1168), WBarnaularsaw

660001

Oncologos del Occidente S.A. ( Site 0206), Pereira

760032

Fundación Valle del Lili ( Site 0202), Santiago de Cali

1240000

Bradford Hill Norte ( Site 1652), Antofagasta

3109601

Rambam Health Care Campus-Oncology Division ( Site 0552), Haifa

4428132

Meir Medical Center ( Site 0556), Kfar Saba

4800827

James Lind Centro de Investigación del Cáncer ( Site 1653), Temuco

4941492

Rabin Medical Center ( Site 0550), Petah Tikva

5265601

Chaim Sheba Medical Center ( Site 0551), Ramat Gan

6423906

Sourasky Medical Center ( Site 0554), Tel Aviv

7500587

Enroll SpA ( Site 1654), Santiago

8410101

Soroka University Medical Center ( Site 0555), Beersheba

8420383

Bradfordhill ( Site 1651), Santiago

9112001

Haddassah Medical Organization - Ein Kerem ( Site 0553), Jerusalem

98700000

ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 0100), Ijuí

92093-0698

UCSD Moores Cancer Center ( Site 1561), La Jolla

06510

Smilow Cancer Center at Yale-New Haven ( Site 1507), New Haven

30322-1013

Winship Cancer Institute of Emory University ( Site 1512), Atlanta

02114

Massachusetts General Hospital ( Site 1518), Boston

02215

Dana Farber Cancer Center ( Site 1519), Boston

07601

John Theurer Cancer Center at Hackensack University Medical Center ( Site 1526), Hackensack

C1027AAP

Centro de Investigaciones Metabólicas (CINME)-Oncology ( Site 0028), Ciudad Autónoma de Buenos Aires

X5008HHW

Centro Medico Privado CEMAIC ( Site 0024), Capital

S2000DEJ

Fundacion Estudios Clinicos-Oncology ( Site 0026), Rosario

S2000KZE

Centro Oncológico de Rosario ( Site 0003), Rosario

C1181ACH

Hospital Italiano- Sociedad Italiana de Beneficencia en Buenos Aires ( Site 0009), Buenos Aires

C1431FWO

CEMIC ( Site 0012), Buenos Aires

C1121ABE

Fundacion CIDEA ( Site 0001), CABA

F5300COE

Centro Oncologico Riojano Integral ( Site 0002), La Rioja

G4200AWD

Centro Oncologico Norte ( Site 0023), Santiago del Estero

60135-237

Oncocentro Ceara ( Site 0108), Fortaleza

81520-060

Hospital Erasto Gaertner ( Site 0101), Curitiba

95700-084

Hospital Tacchini ( Site 0111), Bento Gonçalves

95900-000

Hospital Bruno Born ( Site 0107), Lajeado

99010-080

Hospital Sao Vicente de Paulo ( Site 0105), Passo Fundo

20220-410

Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA-Pesquisa Clinica HC II ( Site 0103), Rio de Janeiro

01509-010

A. C. Camargo Cancer Center ( Site 0116), São Paulo

T2N 4N2

Tom Baker Cancer Center ( Site 0161), Calgary

T6G 1Z2

Cross Cancer Institute ( Site 0159), Edmonton

L8V 1C3

Juravinski Cancer Center ( Site 0151), Hamilton

K1H 8L6

The Ottawa Hospital Cancer Centre ( Site 0154), Ottawa

H1T 2M4

CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0163), Montreal

H4A 3J1

McGill University Health Centre ( Site 0162), Montreal

06200

Hopital ARCHET 2 ( Site 0356), Nice

161 21

Andreas Syggros Hospital ( Site 0450), Athens

124 62

Attikon University General Hospital of Athens ( Site 0454), Chaïdári

185 47

Metropolitan Hospital ( Site 0453), Neo Faliro

564 03

Papageorgiou General Hospital ( Site 0451), Thessaloniki

570 01

European Interbalkan Medical Center ( Site 0455), Thessaloniki

D08 K0Y5

St. James s Hospital ( Site 1601), Dublin

0624

New Zealand Clinical Research (Auckland) ( Site 0800), Auckland

0379

Oslo Universitetssykehus Radiumhospitalet ( Site 0850), Oslo

31-115

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Oddzial w Krakowie ( Site 0959), Krakow

02-781

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0951), Warsaw

80-214

Uniwersyteckie Centrum Kliniczne-Klinika Chirurgii Onkologicznej, Transplantacyjnej i Ogólnej ( Site, Gdansk

44-101

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 0958), Gliwice

8005-226

Hospital Particular do Algarve ( Site 1005), Faro

1099-023

Instituto Portugues de Oncologia de Lisboa ( Site 1003), Lisbon

1350-352

Hospital CUF - Tejo ( Site 1004), Lisbon

1649-035

CHLN Hospital Santa Maria ( Site 1001), Lisbon

4200-072

Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 1000), Porto

031864

Hifu Terramed Conformal SRL ( Site 1111), Bucharest

022548

S.C.Focus Lab Plus S.R.L ( Site 1107), Bucharest

030447

Spitalul de Psihiatrie Titan Dr. Constantin Gorgos ( Site 1112), Bucharest

08908

Hospital Duran i Reynals ( Site 1254), Hospitalet Del Llobregat

08036

Hospital Clinic i Provincial Barcelona ( Site 1253), Barcelona

08035

Hospital General Universitari Vall d Hebron ( Site 1252), Barcelona

03057

Universal Clinic Oberig-Oncology Center ( Site 1461), Kyiv

TR1 3LQ

Royal Cornwall Hospitals NHS Trust ( Site 1402), Truro

NW1 2PG

University College Hospital London ( Site 1400), London

SE1 9RT

Guy s & St Thomas NHS Foundation Trust ( Site 1407), London

SW3 6JJ

The Royal Marsden Hospital-Institute of Cancer Research ( Site 1406), London

SM2 5PT

Royal Marsden NHS Foundation Trust ( Site 1408), Sutton

OX3 7LE

Churchill Hospital ( Site 1404), Oxford

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY