Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine

300 mg of oral Lamotrigine. One of the key studies in this area was reported at the Society of Neuroscience meeting in 1997 and later published in the Archives of General Psychiatry. This study reported that, in healthy subjects 300 mg oral lamotrigine significantly decreased ketamine-induced perceptual abnormalities as assessed by the Clinician-Administered Dissociative States Scale (P\<.001).31 Furthermore lamotrigine increased the immediate mood-elevating effects of ketamine (P\<.05).

300 mg of oral Placebo

1mg/kg bolus at induction followed by 5 microgram/kg/min infusion till the end of the surgery