Immunotherapy SBRT Sensitization of the Programmed Death-1 (PD-1) Effect

PHASE2CompletedINTERVENTIONAL
Enrollment

3

Participants

Timeline

Start Date

April 28, 2017

Primary Completion Date

March 8, 2022

Study Completion Date

March 8, 2022

Conditions
Metastatic Nonsmall Cell Lung CancerNon Small Cell Lung Cancer
Interventions
RADIATION

Stereotactic Body Radiotherapy

"All patients in this trial will be treated with fractionated Stereotactic body radiation therapy.~SBRT will be delivered to \<=3 sites in 3-5 fractions followed by administration of the specified immunotherapy agent (Nivolumab or Pembrolizumab). This approach will take advantage of the transient increase in antigen availability, increased antigen presentation and upregulation of PD-1 by tumor cells following ablative radiation therapy."

Trial Locations (1)

19083

Philadelphia CyberKnife, Philadelphia

All Listed Sponsors
collaborator

Saint Peters University Hospital

OTHER

collaborator

Community Medical Center, Toms River, NJ

OTHER

lead

Crozer-Keystone Health System

OTHER

NCT03825510 - Immunotherapy SBRT Sensitization of the Programmed Death-1 (PD-1) Effect | Biotech Hunter | Biotech Hunter