60
Participants
Start Date
February 20, 2019
Primary Completion Date
October 31, 2026
Study Completion Date
December 31, 2026
Ketorolac
IV Ketorolac to be given over the course of the first 24 hours after surgery. See arm/group description for further details.
Normal saline
An IV normal saline placebo prepared by the hospital pharmacy.
Acetaminophen
acetaminophen 500 mg PO Q4 hours PRN for mild pain
Oxycodone Acetaminophen
oxycodone-acetaminophen 5-325 mg PO Q4 hours PRN for moderate to severe pain
Morphine
morphine IV PRN (or other opioid) for severe breakthrough pain
Hydrocodone/Acetaminophen
At discharge, patients will be prescribed 1-2 hydrocodone-acetaminophen 5-325 mg Q4 hours. Those with preexisting liver disease will be prescribed the equivalent in oxycodone.
Oxycodone
Upon discharge, patients will be prescribed the equivalent of 1-2 hydrocodone 5mg Q4 hours upon should they have preexisting liver disease and are unable to consume acetaminophen.
RECRUITING
Saint Louis University, St Louis
St. Louis University
OTHER