Post-Op Pain Control for Prophylactic Intramedullary Nailing.

PHASE3RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 20, 2019

Primary Completion Date

October 31, 2026

Study Completion Date

December 31, 2026

Conditions
Bone MetastasesLymphomaMultiple MyelomaOpioid UsePain
Interventions
DRUG

Ketorolac

IV Ketorolac to be given over the course of the first 24 hours after surgery. See arm/group description for further details.

DRUG

Normal saline

An IV normal saline placebo prepared by the hospital pharmacy.

DRUG

Acetaminophen

acetaminophen 500 mg PO Q4 hours PRN for mild pain

DRUG

Oxycodone Acetaminophen

oxycodone-acetaminophen 5-325 mg PO Q4 hours PRN for moderate to severe pain

DRUG

Morphine

morphine IV PRN (or other opioid) for severe breakthrough pain

DRUG

Hydrocodone/Acetaminophen

At discharge, patients will be prescribed 1-2 hydrocodone-acetaminophen 5-325 mg Q4 hours. Those with preexisting liver disease will be prescribed the equivalent in oxycodone.

DRUG

Oxycodone

Upon discharge, patients will be prescribed the equivalent of 1-2 hydrocodone 5mg Q4 hours upon should they have preexisting liver disease and are unable to consume acetaminophen.

Trial Locations (1)

63110

RECRUITING

Saint Louis University, St Louis

All Listed Sponsors
lead

St. Louis University

OTHER