Study to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

364

Participants

Timeline

Start Date

February 21, 2019

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
Advanced Solid Tumors Cancer
Interventions
DRUG

Livmoniplimab

Liquid for intravenous infusion.

DRUG

Budigalimab

Lyophilized powder for solution for intravenous infusion.

Trial Locations (64)

100

National Taiwan University Hospital /ID# 218490, Taipei City

333

Linkou Chang Gung Memorial Hospital /ID# 265551, Taoyuan

807

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 257634, Kaohsiung City

833

Kaohsiung Chang Gung Memorial Hospital /ID# 265560, Kaohsiung City

1200

Cliniques Universitaires UCL Saint-Luc /ID# 218466, Brussels

2050

Chris O'Brien Lifehouse /ID# 213236, Camperdown

4101

Icon Cancer Centre /ID# 224961, South Brisbane

10029

Icahn School of Medicine at Mount Sinai /ID# 264653, New York

11217

Taipei Veterans General Hosp /ID# 257635, Taipei

20121

Istituto Europeo Di Oncologia /Id# 266053, Milan

21565

Gachon University Gil Medical Center /ID# 257572, Incheon

28027

Clinica Universidad de Navarra - Madrid /ID# 265299, Madrid

28034

Hospital Universitario Ramón y Cajal /ID# 265298, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz /ID# 220928, Madrid

28050

Hospital Universitario HM Sanchinarro /ID# 265294, Madrid

28078

Carolina BioOncology Institute /ID# 208358, Huntersville

31008

Clinica Universidad de Navarra - Pamplona /ID# 266632, Pamplona

31059

CHU Toulouse - Hopital Purpan /ID# 218667, Toulouse

32804

Duplicate_AdventHealth Cancer Institute - Orlando /ID# 226953, Orlando

40447

China Medical University Hospital /ID# 218492, Taichung

45136

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung /ID# 269587, Essen

46010

Hospital Clinico Universitario de Valencia /ID# 221107, Valencia

46202

Indiana Univ School Medicine /ID# 208384, Indianapolis

48109

Univ Michigan Med Ctr /ID# 221129, Ann Arbor

58128

Chonnam National University Hwasun Hospital /ID# 257573, Hwasun-gun

59106

Intermountain Health West End Clinic Gynecologic Oncology /ID# 266171, Billings

63011

Centre Jean Perrin /ID# 218669, Clermont-Ferrand

63110

Washington University-School of Medicine /ID# 259684, St Louis

69373

Centre Leon Berard /ID# 218515, Lyon

72762

Highlands Oncology Group, PA /ID# 218942, Springdale

73104

Ou Health - Stephenson Cancer Center /ID# 268826, Oklahoma City

78229

NEXT Oncology /ID# 208930, San Antonio

91010

City of Hope National Medical Center /ID# 265620, Duarte

91120

Hadassah Medical Center-Hebrew University /ID# 257918, Jerusalem

92618

City of Hope Orange County Lennar Foundation Cancer Center /ID# 270785, Irvine

94805

Institut Gustave Roussy /ID# 218668, Villejuif

98195

University of Washington Medical Center /ID# 268854, Seattle

3109601

Rambam Health Care Campus /ID# 222198, Haifa

4941492

Rabin Medical Center /ID# 258479, Petah Tikva

5265601

The Chaim Sheba Medical Center /ID# 209037, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 222199, Tel Aviv

06510

Yale University School of Medicine /ID# 208356, New Haven

34747-4970

AdventHealth Celebration /ID# 224860, Celebration

46250-2042

Community Health Network, Inc. /ID# 257032, Indianapolis

10016-6402

NYU Langone Medical Center /ID# 209822, New York

43210-1240

The Ohio State University - The James /ID# 217611, Columbus

37203-5755

Sarah Cannon Research Institute (SMO/Network/Consortium) /ID# 264900, Nashville

79915-1803

Renovatio clinical /ID# 265109, El Paso

77380-3181

Renovatio Clinical /ID# 265054, The Woodlands

M5G 2M9

University Health Network_Princess Margaret Cancer Centre /ID# 209423, Toronto

277-8577

National Cancer Center Hospital East /ID# 224808, Kashiwa-shi

673-8558

Hyogo Cancer Center /ID# 272553, Akashi-shi

104-0045

National Cancer Center Hospital /ID# 209421, Chuo-ku

30-348

Jagiellonskie Centrum Innowacji Sp. z o.o. /ID# 266194, Krakow

02-781

Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 266147, Warsaw

93-338

Instytut Centrum Zdrowia Matki Polki /ID# 266324, Lodz

00935

Pan American Center for Oncology Trials, LLC /ID# 217475, Rio Piedras

02841

Korea University Anam Hospital /ID# 257574, Seoul

03080

Seoul National University Hospital /ID# 218513, Seoul

05505

Asan Medical Center /ID# 266799, Seoul

06351

Samsung Medical Center /ID# 265865, Seoul

03722

Yonsei University Health System Severance Hospital /ID# 218512, Seoul

08035

Hospital Universitari Vall d'Hebron /ID# 265290, Barcelona

08036

Hospital Clinic de Barcelona /ID# 221106, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY