A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

242

Participants

Timeline

Start Date

November 22, 2018

Primary Completion Date

November 22, 2024

Study Completion Date

November 22, 2027

Conditions
Acute Lymphoblastic Leukemia
Interventions
DRUG

Fludarabine

IV

DRUG

Melphalan

IV

DRUG

Alemtuzumab

IV

DRUG

Cyclophosphamide

IV

DRUG

Mesna

IV

RADIATION

Total Body Irradiation (8Gy)

TBI (8Gy)

Trial Locations (22)

B95ST

Heart of England Nhs Foundation Trust, Birmingham

Unknown

University Hospitals Birmingham Nhs Foundation Trust, Birmingham

Central Manchester University Hospitals Nhs Foundation Trust, Manchester

The Newcastle Upon Tyne Hospitals Nhs Foundation Trust, Newcastle

BS13NU

University Hospitals Bristol Nhs Foundation Trust, Bristol

CB20QQ

Cambridge University Hospitals Nhs Foundation Trust, Cambridge

CF144XW

Cardiff and Vale University Health Board, Cardiff

G12 0YN

NHS Greater Glasgow and Clyde, Glasgow

LS9 7TF

Leeds Teaching Hospitals Nhs Trust, Leeds

LE15WW

University Hospitals of Leicester Nhs Trust, Leicester

CH634JY

The Clatterbridge Cancer Centre Nhs Foundation Trust, Liverpool

E11BB

Barts Health Nhs Trust, London

NW12PG

University College London Hospitals Nhs Foundation Trust, London

SE5 9RS

Kings College Hospital, London

SW3 6JJ

The Royal Marsden Nhs Foundation Trust, London

W21NY

Imperial College Healthcare Nhs Trust, London

M204BX

The Christie Nhs Foundation Trust, Manchester

NG72UH

Nottingham University Hospitals Nhs Trust, Nottingham

OX3 9DU

Oxford University Hospitals Nhs Foundation Trust, Oxford

PL68DH

Plymouth Hospitals Nhs Trust, Plymouth

S57AU

Sheffield Teaching Hospitals Nhs Foundation Trust, Sheffield

SO16 6YD

University Hospital Southampton Nhs Foundation Trust, Southampton

All Listed Sponsors
lead

University of Birmingham

OTHER

NCT03821610 - A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC) | Biotech Hunter | Biotech Hunter