Higher Neural Changes Following Anticholinergic, Beta 3 Agonist, or Placebo in Patients With Overactive Bladder

PHASE4CompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

August 5, 2019

Primary Completion Date

February 2, 2022

Study Completion Date

February 26, 2022

Conditions
Overactive BladderDementiaLower Urinary Tract SymptomsIncontinence, Urge
Interventions
DRUG

Anticholinergic

Tablet taken once daily.

DRUG

Beta-3 Agonists, Adrenergic

Tablet taken once daily.

DIAGNOSTIC_TEST

Functional magnetic resonance imaging (fMRI)

All subjects have fMRI at baseline and again after 30 days

DIAGNOSTIC_TEST

Rey Auditory Verbal Learning Test (RAVLT)

All subjects have RAVLT at baseline and again after 30 days. RAVLT evaluates: short-term auditory-verbal memory, rate of learning, learning strategies, retroactive, and proactive interference, presence of confabulation of confusion in memory processes, retention of information, and differences between learning and retrieval.

Trial Locations (2)

75608

Baylor Scott and White Health, Temple

77030

Houston Methodist Hospital, Houston

Sponsors
All Listed Sponsors
collaborator

The Methodist Hospital Research Institute

OTHER

collaborator

International Urogynecological Association

OTHER

lead

Baylor Research Institute

OTHER