NCT03816072View on ClinicalTrials.gov

Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia

NACompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

January 7, 2019

Primary Completion Date

September 23, 2019

Study Completion Date

September 23, 2019

Conditions

Cerebrovascular Circulation

Interventions

DRUG

Phenylephrine infusion

Correction of anesthesia induced hypotension with phenylephrine to obtain sCA and dCA measurements at 60, 70, 80, 90 and 100 mmHg mean blood pressure. This is achieved by stepwise increases in phenylephrine infusion dose.

OTHER

Mechanical ventilation

Patientes are mechanically ventilated at 6 bpm to obtain low frequency blood pressure oscillations (\~0.1 Hz).

DRUG

Propofol

DRUG

Sevoflurane

Trial Locations (1)

1105 AZ

Amsterdam UMC, location AMC, Amsterdam

All Listed Sponsors

lead

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

OTHER

NCT03816072 - Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia | Biotech Hunter | Biotech Hunter