GOLDEN STUDY: A Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

PHASE2CompletedINTERVENTIONAL
Enrollment

332

Participants

Timeline

Start Date

March 4, 2019

Primary Completion Date

April 18, 2024

Study Completion Date

June 12, 2024

Conditions
Macular DegenerationGeographic Atrophy
Interventions
DRUG

IONIS-FB-LRx

IONIS-FB-LRx at multiple ascending doses, administered subcutaneously every 4 weeks

DRUG

Placebo

Placebo matching solution, administered subcutaneously every 4 weeks

Trial Locations (88)

1090

IONIS Investigative Site, Vienna

1140

IONIS Investigative Site, Vienna

2000

IONIS Investigative Site, Sydney

2150

IONIS Investigative Site, Parramatta

2228

IONIS Investigative Site, Hurstville

2640

IONIS Investigative Site, Albury

3002

IONIS Investigative Site, East Melbourne

3040

IONIS Investigative Site, Essendon

3050

IONIS Investigative Site, Parkville

3144

IONIS Investigative Site, Malvern

3146

IONIS Investigative Site, Glen Iris

4020

IONIS Investigative Site, Linz

5000

IONIS Investigative Site, Adelaide

6009

IONIS Investigative Site, Perth

8013

IONIS Investigative Site, Christchurch

8022

IONIS Investigative Site, Barcelona

8034

IONIS Investigative Site, Barcelona

8227

IONIS Investigative Site, Terrassa

9020

IONIS Investigative Site, Klagenfurt

15000

IONIS Investigative Site, Prague

15122

IONIS Investigative Site, West Mifflin

15213

IONIS Investigative Site, Pittsburgh

19104

IONIS Investigative Site, Philadelphia

21204

IONIS Investigative Site, Baltimore

21209

IONIS Investigative Site, Baltimore

21740

IONIS Investigative Site, Hagerstown

23235

IONIS Investigative Site, Richmond

24502

IONIS Investigative Site, Lynchburg

27157

IONIS Investigative Site, Winston-Salem

28222

IONIS Investigative Site, Majadahonda

28602

IONIS Investigative Site, Hickory

28803

IONIS Investigative Site, Asheville

29456

IONIS Investigative Site, Ladson

29605

IONIS Investigative Site, Greenville

30909

IONIS Investigative Site, Augusta

31008

IONIS Investigative Site, Pamplona

32901

IONIS Investigative Site, Melbourne

33461

IONIS Investigative Site, Lake Worth

33612

IONIS Investigative Site, Tampa

33761

IONIS Investigative Site, Clearwater

33801

IONIS Investigative Site, Lakeland

33880

IONIS Investigative Site, Winter Haven

33907

IONIS Investigative Site, Fort Myers

34994

IONIS Investigative Site, Stuart

37203

IONIS Investigative Site, Nashville

38671

IONIS Investigative Site, Southaven

44106

IONIS Investigative Site, Cleveland

44130

IONIS Investigative Site, Cleveland

44195

IONIS Investigative Site, Cleveland

46100

IONIS Investigative Site, Burjassot

47012

IONIS Investigative Site, Valladolid

50009

IONIS Investigative Site, Zaragoza

60439

IONIS Investigative Site, Lemont

62702

IONIS Investigative Site, Springfield

66211

IONIS Investigative Site, Leawood

74114

IONIS Investigative Site, Tulsa

75231

IONIS Investigative Site, Dallas

76012

IONIS Investigative Site, Arlington

76051

IONIS Investigative Site, Southlake

76087

IONIS Investigative Site, Willow Park

77384

IONIS Investigative Site, The Woodlands

77401

IONIS Investigative Site, Bellaire

78240

IONIS Investigative Site, San Antonio

78503

IONIS Investigative Site, McAllen

78705

IONIS Investigative Site, Austin

79606

IONIS Investigative Site, Abilene

80909

IONIS Investigative Site, Colorado Springs

84107

IONIS Investigative Site, Salt Lake City

85020

IONIS Investigative Site, Phoenix

85021

IONIS Investigative Site, Phoenix

85053

IONIS Investigative Site, Phoenix

85351

IONIS Investigative Site, Sun City

87109

IONIS Investigative Site, Albuquerque

90211

IONIS Investigative Site, Beverly Hills

90807

IONIS Investigative Site, Long Beach

92064

IONIS Investigative Site, Poway

92093

IONIS Investigative Site, La Jolla

92697

IONIS Investigative Site, Huntington Beach

94109

IONIS Investigative Site, San Francisco

98383

IONIS Investigative Site, Silverdale

N6A 4V2

IONIS Investigative Site, London

K1H 8L6

IONIS Investigative Site, Ottawa

K2B 7E9

IONIS Investigative Site, Ottawa

G1S 4L8

IONIS Investigative Site, Québec

6525EX

IONIS Investigative Site, Nijmegen

3011 BH

IONIS Investigative Site, Rotterdam

40-514

IONIS Investigative Site, Katowice

85-631

IONIS Investigative Site, Bydgoszcz

Sponsors
All Listed Sponsors
lead

Ionis Pharmaceuticals, Inc.

INDUSTRY