Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C

PHASE3CompletedINTERVENTIONAL
Enrollment

3,275

Participants

Timeline

Start Date

April 16, 2019

Primary Completion Date

February 13, 2023

Study Completion Date

February 13, 2023

Conditions
ASCVDElevated CholesterolHeterozygous Familial HypercholesterolemiaHomozygous Familial Hypercholesterolemia
Interventions
DRUG

Inclisiran Sodium

Inclisiran is a small interfering ribonucleic acid (RNA) that inhibits PCSK9 synthesis.

Trial Locations (238)

1035

Research Site 90027-009, Witbank

1619

Research Site 11027-005, Kempton Park

2193

Research Site 90027-010, Johannesburg

2650

Research Site 90045-006, Hvidovre

4000

Research Site 90045-002, Roskilde

5009

Research Site 90034-002, Zaragoza

6700

Research Site 90045-004, Esbjerg

7130

Research Site 90027-004, Somerset West

Research Site 90027-005, Somerset West

7400

Research Site 90045-003, Herning

7500

Research Site 90027-001, Cape Town

7530

Research Site 90027-008, Bellville

7580

Research Site 11027-007, Kuils River

7646

Research Site 11027-013, Paarl

8800

Research Site 90045-005, Viborg

9000

Research Site 90045-001, Aalborg

9301

Research Site 90027-003, Bloemfontein

12206

Research Site 10001-054, Albany

12553

Research Site 10001-042, New Windsor

12601

Research Site 10001-129, Poughkeepsie

12627

Research Site 11049-006, Berlin

13760

Research Site 10001-128, Endwell

13901

Research Site 10001-122, Binghamton

14004

Research Site 90034-004, Córdoba

14221

Research Site 10001-110, Williamsville

15002

Research Site 90034-003, A Coruña

19610

Research Site 10001-109, Wyomissing

20110

Research Site 10001-085, Manassas

22042

Research Site 10001-093, Falls Church

23114

Research Site 10001-094, Midlothian

23294

Research Site 10001-023, Richmond

23435

Research Site 10001-029, Suffolk

27401

Research Site 10001-064, Greensboro

27518

Research Site 10001-063, Cary

28117

Research Site 10001-145, Mooresville

28150

Research Site 10001-046, Shelby

29588

Research Site 10001-111, Myrtle Beach

29621

Research Site 10001-001, Anderson

29651

Research Site 10001-006, Greer

Research Site 10001-075., Greer

29669

Research Site 10001-133, Pelzer

30338

Research Site 10001-137, Dunwoody

30342

Research Site 10001-069, Atlanta

31210

Research Site 10001-092, Macon

32003

Research Site 10001-119, Fleming Island

32081

Research Site 10001-104, Ponte Vedra

32086

Research Site 10001-090, Saint Augustine

32117

Research Site 10001-127, Daytona Beach

32204

Research Site 10001-139, Jacksonville

32216

Research Site 10001-039, Jacksonville

Research Site 10001-098, Jacksonville

33012

Research Site 10001-067, Hialeah

33024

Research Site 10001-027, Pembroke Pines

33027

Research Site 10001-115, Pembroke Pines

33029

Research Site 10001-048, Pembroke Pines

Research Site 10001-147, Pembroke Pines

33126

Research Site 10001-081, Miami

Research Site 10001-140, Miami

Research Site 10001-142, Miami

33165

Research Site 10001-030, Miami

33166

Research Site 10001-080, Miami Springs

33183

Research Site 10001-116, Miami

33308

Research Site 10001-070, Fort Lauderdale

33434

Research Site 90001-047, Boca Raton

33614

Research Site 10001-143, Tampa

33713

Research Site 10001-102, St. Petersburg

33756

Research Site 10001-084, Clearwater

Research Site 10001-155, Clearwater

33761

Research Site 10001-099, Clearwater

33781

Research Site 10001-003, Pinellas Park

35211

Research Site 10001-015, Birmingham

35801

Research Site 10001-113, Huntsville

36117

Research Site 10001-037, Montgomery

36535

Research Site 10001-138, Foley

36571

Research Site 10001-076, Saraland

36608

Research Site 10001-058, Mobile

37303

Research Site 10001-146, Athens

37660

Research Site 10001-130, Kingsport

37909

Research Site 10001-118, Knoxville

37917

Research Site 10001-106, Knoxville

40503

Research Site 10001-125, Lexington

40504

Research Site 10001-108, Lexington

42303

Research Site 10001-107, Owensboro

43204

Research Site 90034-001, Reus

43212

Research Site 10001-014, Columbus

43302

Research Site 10001-148, Marion

45219

Research Site 10001-120, Cincinnati

45227

Research Site 90001-002, Cincinnati

45236

Research Site 10001-010, Cincinnati

45246

Research Site 10001-134, Cincinnati

45419

Research Site 10001-141, Dayton

46260

Research Site 10001-082, Indianapolis

46383

Research Site 10001-040, Valparaiso

47787

Research Site 11049-002, Bochum

48098

Research Site 10001-034, Troy

48310

Research Site 10001-078, Sterling Heights

48504

Research Site 10001-024, Flint

49418

Research Site 10001-095, Grandville

50266

Research Site 10001-074, West Des Moines

55102

Research Site 90001-056, Saint Paul

55435

Research Site 10001-018, Edina

57701

Research Site 10001-103, Rapid City

59701

Research Site 90001-012, Butte

60005

Research Site 10001-059, Arlington Heights

60201

Research Site 10001-036, Evanston

60313

Research Site 11049-003, Frankfurt

60652

Research Site 10001-158, Chicago

61176

Research Site 11380-008, Kharkiv

63136

Research Site 10001-156, St Louis

63141

Research Site 10001-007, St Louis

67502

Research Site 10001-028, Hutchinson

68134

Research Site 10001-053, Omaha

68144

Research Site 10001-021, Omaha

69120

Research Site 11049-001, Heidelberg

Research Site 11049-007, Heidelberg

70526

Research Site 10001-144, Crowley

70601

Research Site 10001-041, Lake Charles

71201

Research Site 10001-101, Monroe

75234

Research Site 10001-009, Dallas

77002

Research Site 10001-031, Houston

77024

Research Site 10001-088, Houston

77027

Research Site 10001-091, Houston

77058

Research Site 10001-061, Houston

77070

Research Site 10001-032, Houston

77375

Research Site 10001-045, Tomball

78130

Research Site 10001-057, New Braunfels

78154

Research Site 10001-083, Schertz

78229

Research Site 10001-071, San Antonio

78231

Research Site 10001-149, Shavano Park

78503

Research Site 10001-068, Edinburg

78681

Research Site 10001-079, Round Rock

78726

Research Site 10001-087, Austin

78756

Research Site 10001-117, Austin

79106

Research Site 10001-100, Amarillo

84041

Research Site 10001-005, Layton

84123

Research Site 10001-002, Salt Lake City

85014

Research Site 10001-136, Phoenix

85213

Research Site 10001-077, Mesa

85224

Research Site 10001-013, Chandler

85374

Research Site 10001-051, Surprise

85712

Research Site 10001-019, Tucson

85741

Research Site 10001-004, Tucson

85745

Research Site 10001-132, Tucson

88000

Research Site 11380-006, Uzhhorod

89119

Research Site 90001-112, Las Vegas

89121

Research Site 10001-124, Las Vegas

90022

Research Site 10001-150, Los Angeles

90211

Research Site 10001-073, Beverly Hills

90502

Research Site 10001-044, Torrance

91303

Research Site 10001-050, Canoga Park

91324

Research Site 10001-043, Northridge

91325

Research Site 10001-022, Northridge

91978

Research Site 10001-153, Spring Valley

92008

Research Site 10001-011, Carlsbad

92020

Research Site 10001-065, El Cajon

92691

Research Site 90001-005, Mission Viejo

94107

Research Site 10001-052, Salt Lake City

94305

Research Site 90001-015, Stanford

94582

Research Site 10001-105, San Ramon

95405

Research Site 10001-008, Santa Rosa

98405

Research Site 10001-114, Tacoma

443311

Research Site 10001-016, Akron

95821-2134

Research Site 10001-033, Sacramento

34239-3513

Research Site 10001-123, Sarasota

02114

Research Site 90001-004, Boston

08807

Research Site 10001-060, Bridgewater

07901

Research Site 90001-014, Summit

07059

Research Site 10001-055, Warren Township

G7H 7K9

Research Site 90011-005, Chicoutimi

H2W 1R7

Research Site 90011-001, Montreal

GIV 4W2

Research Site 90011-002, Québec

430 02

Research Site 11420-002, Chomutov

140 21

Research Site 90420-001, Prague

180 81

Research Site 90420-006, Prague

686 01

Research Site 11420-003, Uherské Hradiště

Unknown

Research Site 11036-001, Budapest

Research Site 11036-004, Debrecen

Research Site 11036-002, Hatvan

Research Site 11036-003, Zalaegerszeg

Research Site 90031-005, Utrecht

Research SIte 11048-016, Brzozowie

Research Site 11048-011, Bydgoszcz

Research Site 11048-004, Gdansk

Research Site 11048-005, Gdynia

Research Site 11048-007, Katowice

Research SIte 11048-012, Katowice

Research Site 11048-003, Krakow

Research SIte 11048-014, Krakow

Research Site 11048-008, Lublin

Research Site 11048-001, Poznan

Research SIte 11048-013, Rzeszów

Research SIte 11048-015, Tarnów

Research Site 11048-006, Warsaw

Research Site 11048-009, Warsaw

Research Site 11048-002, Wroclaw

Research Site 11048-010, Wroclaw

Research Site 11380-005, Cherkasy

Research Site 11380-004, Kyiv

Research Site 11380-009, Zaporizhzhya

Research Site 11044-026, Bury

Research Site 11044-024, Cheadle Hulme

Research Site 11044-014, Chorley

Research Site 11044-012, Cornwell

Research Site 11044-010, Derby

Research Site 11044-006, Edgbaston

Research Site 11044-009, Exeter

Research Site 11044-001, Glasgow

Research Site 11044-008, Hexham

Research SIte 11044-020, Macclesfield

Research Site 11044-005, Manchester

Research Site 11044-025, Manchester

Research Site 11044-027, Manchester

Research Site 11044-029, Manchester

Research Site 11044-019, Plymouth

Research Site 11044-003, Reading

Research Site 11044-022, Sale

Research Site 11044-023, Sale

Research Site 11044-002, Stockton-on-Tees

Research Site 11044-021, Timperley

Research Site 11044-007, Wales

Research Site 11044-004, Waterloo

3813 TZ

Research Site 90031-001, Amersfoort

1105 AZ

Research Site 90031-003, Amsterdam

4462 RA

Research Site 90031-006, Goes

1624 NP

Research Site 90031-009, Hoorn

85-079

Research Site 11048-018, Bydgoszcz

41-709

Research Site 11048-019, Ruda Śląska

0157

Research Site 90027-007, Lyttelton

0184

Research Site 90027-006, Pretoria

08036

Research Site 90034-005, Barcelona

08907

Research Site 90034-006, Barcelona

SE-41346

Research Site 90046-002, Gothenburg

SE-11446

Research Site 90046-001, Stockholm

SE-14186

Research Site 90046-003, Stockholm

02002

Research Site 11380-001, Kyiv

03037

Research Site 11380-002, Kyiv

03049

Research Site 11380-003, Kyiv

SK10 5JH

Research Site 11044-028, Bollington

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY