Effect of Food on Blood Levels of ASTX727

PHASE1CompletedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

November 8, 2018

Primary Completion Date

June 14, 2019

Study Completion Date

December 16, 2019

Conditions
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaAcute Myeloid Leukemia
Interventions
DRUG

ASTX727 + Day 2 Food

ASTX727 is an oral drug product composed of a fixed-dose combination of cedazuridine (E7727), a CDA inhibitor, and decitabine. Food is a high-calorie, high-fat breakfast meal of 800-1000 calories given on Day 2.

DRUG

ASTX727 + Day 4 Food

ASTX727 is an oral drug product composed of a fixed-dose combination of cedazuridine (E7727), a CDA inhibitor, and decitabine. Food is a high-calorie, high-fat breakfast meal of 800-1000 calories given on Day 4.

Trial Locations (4)

14263

Roswell Park, Buffalo

37232

Vanderbilt, Nashville

44718

Gabrail Cancer Center, Canton

78229

Mays Cancer Center UT Health San Antonio MD Anderson Cancer Center, San Antonio

Sponsors
All Listed Sponsors
lead

Astex Pharmaceuticals, Inc.

INDUSTRY