1,500
Participants
Start Date
May 8, 2019
Primary Completion Date
December 25, 2026
Study Completion Date
November 7, 2027
Semaglutide
Participants will get one dose of semaglutide once weekly in addition to their diabetes medicines - which treatment they get is decided by chance. Participants will inject the study medicine using a pre-filled PDS290 pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. Participants will start with once-weekly doses of 0.25 mg for 4 weeks, then the dose will be gradually increased to 0.5 mg once weekly for 4 weeks, and finally to 1.0 mg once weekly (maximum dose) up to 260 weeks (5 years).
Placebo (semaglutide)
Participants will get one dose of placebo (semaglutide) once weekly in addition to their diabetes medicines - which treatment they get is decided by chance. Participants will inject the study medicine using a pre-filled PDS290 pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. Participants will start with once-weekly doses of 0.25 mg for 4 weeks, then the dose will be gradually increased to 0.5 mg once weekly for 4 weeks, and finally to 1.0 mg once weekly (maximum dose) up to 260 weeks (5 years).
Medical Centre Pulss 5, Riga
"DCC VII - Sofia, Endocrinology Consulting Room", Sofia
"MHAT Knyaginya Klementina -Sofia EAD", Sofia
"USHATE Akad. Ivan Penchev Second Clinic of Endocrinology", Sofia
"Fourth MHAT-Sofia EAD", Sofia
"DCC XX - Sofia EOOD, Endocrinology Consulting Room", Sofia
Medical centre Vitclinic EOOD, Sofia
Zemgales diabetes centre, Jelgava
"MHAT Med Line Clinic", Plovdiv
"UMHAT Sveti Georgi, Clinic of Endocr. and Metab. Diseases", Plovdiv
MHAT MC-Sv Ivan Rilski EOOD, Plovdiv
Teterovska practice, Ogre
DCC I- Pleven EOOD, Pleven
MHAT Sveti Pantaleimon - Pleven, Internal Diseases, Pleven
NYC Research, Inc., New York
CHC Zvezdara, Clinical department for endocrinology, Belgrade
Endocrinology, Diabetes and Metabolism Diseases Clinic, Belgrade
Clinical Hospital Center Bezanijska Kosa, Belgrade
"Laiko General Hospital of Athens", Athens
University Hospital of Athens ATTIKON, Athens
Instituto Nacional de Nutricion - Unidad de Inv de Enf Metab, Distrito Federal
Complejo Hospitalario Universitario A Coruña, A Coruña
Clinical Centre Nis, Endocrinology, Diabetes and Metabolism, Niš
Tristar Clin Investigations, PC, Philadelphia
Diabetes-Zentrum-Wilhelmsburg GbR, Hamburg
Wendisch/Dahl Hamburg (DZHW), Hamburg
Wendisch/Dahl Hamburg, Hamburg
OnSite Clinical Solutions, LLC, Charlotte
Mountain Diabetes & Endocrine Center, Asheville
Endo Res Solutions Inc, Roswell
Atlanta Diabetes Associates, Atlanta
Clinica Universitaria de Navarra, Pamplona
Rambam MC - Diabetes and obesity center of excellence, Haifa
Est Cst Inst for Rsrch,Jksnvil, Jacksonville
Innovative Research of W FL, Clearwater
Renstar Medical Research, Ocala
Vanderbilt Diab Obes Clin Tri, Nashville
Univ Diab & Endo Consultants, Chattanooga
Holston Medical Group, Kingsport
L-MARC Research Center, Louisville
Kentucky Diabetes-Endocrinology Center, Lexington
The Research Group of Lexington LLC, Lexington
Hospital Virgen de la Macarena, Seville
Four Rivers Clinical Research Inc, Paducah
Meir MC - Diabetes unit, Kfar Saba
Hospital La Fe - Endocrinología y Nutrición, Valencia
American Health Network of Indiana, LLC_Avon, Avon
Michigan Medicine, Ann Arbor
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose, Münster
MedicalCenter am Clemenshospital - Schwerpunktpraxis für Diabetologie und Ernährungsmedizin, Münster
Rabin MC Beilinson - Endo unit, Petah Tikva
Iowa Diab & Endo Res Center, West Des Moines
Sheba MC - Endocrinology Clinic, Tel Litwinsky
"Ippokrateio G.H. of Thessaloniki", Thessaloniki
"Thermi Private Hosital", Thessaloniki
Apex Medical Research Inc, Chicago
The University Of Chicago, Chicago
Fakultni nemocnice Brno, Brno
Institute of Endocrinology, metabolism and hypertension, Tel Aviv
Hospital Universitario Dr. José Eleuterio González_Monterrey, Monterrey
Praxis Denger/Pfitzner, Friedrichsthal, Friedrichsthal
Zentrum für klinische Studien Alexander Segner, Saint Ingbert-Oberwürzbach
Praxis Dr. med. Wenzl-Bauer, Rehlingen-Siersburg
Harold Hamm Diabetes Center, Oklahoma City
Velocity Clinical Res-Dallas, Dallas
Simcare Medical Research, LLC, Sugar Land
Clinical Trials of Texas, LLC, San Antonio
VIP Trials, San Antonio
Consano Clinical Research, LLC, Shavano Park
Central Texas Clinical Research, Austin
Texas Diab & Endo, P.A., Austin
Barbara Davis Center, Aurora
Rocky Mount Reg VA Med-DN, Aurora
Del Sol Research Management, LLC, Tucson
University of New Mexico, Albuquerque
Downtown LA Res Ctr. Inc., Los Angeles
Torrance Clin Res Inst, Inc., Lomita
Hadassah Ein Karam MC - Diabetes Unit, Jerusalem
Scripps Whittier Diabetes Inst, La Jolla
Southern California Res Ctr, Coronado
FDRC, Costa Mesa
Diabetes/Lipid Mgmt & Res Ctr, Huntington Beach
Coastal Metabolic Research Center, Ventura
Diablo Clinical Research, Inc., Walnut Creek
Clinical Trials Research_Sacramento_0, Sacramento
MultiCare Inst for Res & Innov, Spokane
All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029
All India Institute of Medical Sciences, New Dehli
Apollo Hospital, Delhi
Indraprastha Apollo Hospital, Delhi
FSBI 'I.I. Dedov National Medical Research Center of Endocrinology' of the MH of Russia, Moscow
National Medical Research Center of Endocrinology, Moscow
Christian Medical College and Hospital, Ludhiana
City Consultative & Diagnostic Centre #1, Saint Petersburg
"Diagnistic Centre Energo", Saint Petersburg
Consultative & Diagnostic Center with a Outpatient Hospital, Saint Petersburg
3rd Clinic for Nutrition-Spitalulul Județean de Urgenta, Timișoara
Clinic of Diabetes Cluj, Cluj-Napoca
BYL Nair Hospital and T N Medical College Department of endo, Mumbai
SHI Saratov City Clinical Hospital #9, Saratov
Regional clinical cardiology dispensary, Saratov
Deenanath Mangeshkar Hospital & Research Centre, Pune
Kazan Federal University, Kazan'
"PIH Clin Hosp RZD-Medicina former Kazan OJSC Rus Railways", Kazan'
Government Medical College and Super Speciality Hospital, Nagpur, Nagpur
Endolife Specialty Hospitals, Guntur
Diacon Hospital Private Limited, Bangalore
Care Hospital, Hyderabad
Madras Diabetes Research Foundation, Chennai
Multispecialty Medical Clinic Anturium LLC, Barnaul
Amrita Institute Of Medical Sciences & Research Centre, Kochi
Indian Institute of Diabetes, Thiruvananthapuram
Indian Institute of Diabetes, Thiruvnanthapuram
Apollo Gleneagles Hospital, Kolkata
Rancho Cucamonga Clinical Research, Rancho Cucamonga
Chase Medical Research LLC, Waterbury
Brigham & Women's Hospital, Boston
Boston Medical Center_Cary, Boston
Joslin Center For Diabetes, Boston
Joslin Diabetes Center, Boston
Holston Medical Group Pc, Bristol
UT Southwestern Med Cntr, Dallas
CPQuali Pesquisa Clínica Ltda, São Paulo
Alberta Diabetes Institute, Edmonton
LMC Clinical Res Thornhill, Concord
LMC Endo Ctr (Etobicoke) Ltd, Etobicoke
LMC Endo Centres Ltd.(Bayview), Toronto
Centricity Res Pointe-Claire, Pointe-Claire
LMC Clin Rsrch Inc. (Montreal), Saint-Laurent
Fakultni nemocnice Hradec Kralove, Hradec Králové
Diabetologie Krupska, Prague
Fakultni nemocnice Kralovske Vinohrady_Praha, Prague
Institut klinicke a experimentalni mediciny, Prague
MUDr. Michala Pelikanova, Prague
Iatriko Psychicou Private Clinic, Athens
"Laiko General Hospital of Athens", Athens
Iatriko Athinon 'Palaiou Falirou', Athens
University Hospital of Athens ATTIKON, Haidari-Athens
"Thermi Private Hosital", Thessaloniki
Narayana Hrudayalya Institute of Cardiac Sciences, Bangalore
Arthur Asirvatham hospital,, Madurai
P. Stradins Clinical University Hospital, Riga
Juglas Medicine Center, Riga
Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok
In-Vivo Sp. z o.o., Bydgoszcz
B_Serwis Popenda Sp.J., Chorzów
Synexus Polska Sp. z o.o. Oddzial w Gdansku, Gdansk
NZOZ Gdanska Poradnia Cukrzycowa Sp.z o.o., Gdansk
Centrum Medyczne Pratia Katowice, Katowice
FutureMeds Sp. z o.o., Krakow
Santa Sp. z o.o, Santa Familia Centrum Badan, Profilaktyki i Leczenia, Lodz
Santa Sp. z o.o, Santa Familia Centrum Badan, Profilaktyki i Leczenia, Lodz
Prywatny Gabinet Lekarski Jan Ruxer, Lodz
"NZOZ DiabMed Poradnia Diabetologiczna", Poznan
Gaja Poradnie Lekarskie, Poznan
SPSK nr 1 im. prof. Stanisława Szyszko Śląskiego Uniwersytetu Medycznego w Katowicach, ul. 3-go Maja 13/15 41-800 Zabrze, Zabrze
Unidade Local De Saude De Matosinhos E.P.E., Senhora Da Hora, Matosinhos
Unidade Local De Saude De Almada-Seixal E.P.E. - Hospital Garcia de Orta, Almada
Unidade Local De Saude Da Regiao De Aveiro E.P.E., Aveiro
Unidade Local de Saúde de Coimbra, E.P.E., Coimbra
Unidade Local de Saude do Alto Ave, E.P.E., Guimarães
APDP - Associação Protectora dos Diabéticos de Portugal, Lisbon
Centro Hospitalar de São João, Porto
Unidade Local de Saude de Sao Joao E.P.E, Porto
Unidade Local de Saúde da Arrábida, E.P.E., Setúbal
Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila, Bucharest
"Carol Davila Military Emergency Hospital", Bucharest
Sana Monitoring SRL, Bucharest
SC Clinica Diabnutrimed S.R.L., Bucharest
Nemocnica akademika L. Derera, UNB, Bratislava
Diabetologicka ambulancia, Dia Zilina s.r.o., Žilina
Medivasa s.r.o., Diabetologicka ambulancia, Žilina
MEDIVASA, s.r.o., Diabetologicka ambulancia, Žilina
Hospital Vall d'Hebron, Barcelona
Hospital de Bellvitge, L'Hospitalet de Llobregat
Harrogate District Hospital, Harrogate
University Hospital, Queens Medical Centre, Nottingham
Yeovil District Hospital - Clinical Research Unit, Yeovil
Clinical Research Unit, Somerset
Kings College Hospital, London
The Norfolk and Norwich University Hospital, Norfolk
George Eliot Hospital NHS Trust, Nuneaton
Royal Cornwall Hospital (Treliske), Truro
Lead Sponsor
Novo Nordisk A/S
INDUSTRY