Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion

PHASE3TerminatedINTERVENTIONAL
Enrollment

493

Participants

Timeline

Start Date

July 3, 2019

Primary Completion Date

July 26, 2021

Study Completion Date

July 26, 2021

Conditions
Central Retinal Vein Occlusion
Interventions
DRUG

Brolucizumab 6 mg

Solution for injection (intravitreal use)

DRUG

Aflibercept 2 mg

Solution for injection (Intravitreal use)

OTHER

Sham injection

Empty sterile syringe without a needle administered as a sham injection for masking. From Week 24 to Week 72 inclusive, a sham treatment was performed to maintain subject masking in case treatment with brolucizumab or aflibercept was not deemed necessary by the investigator.

Trial Locations (120)

1083

Novartis Investigative Site, Budapest

2000

Novartis Investigative Site, Sydney

2135

Novartis Investigative Site, Strathfield

2150

Novartis Investigative Site, Parramatta

2640

Novartis Investigative Site, Albury

3002

Novartis Investigative Site, Melbourne

4012

Novartis Investigative Site, Debrecen

6009

Novartis Investigative Site, Nedlands

7000

Novartis Investigative Site, Hobart

7621

Novartis Investigative Site, Pécs

8022

Novartis Investigative Site, Barcelona

10330

Novartis Investigative Site, Bangkok

12808

Novartis Investigative Site, Prague

15146

Novartis Investigative Site, Monroeville

20080

Novartis Investigative Site, Donostia / San Sebastian

20100

Novartis Investigative Site, Milan

20122

Novartis Investigative Site, Milan

20132

Novartis Investigative Site, Milan

21034

Novartis Investigative Site, Dijon

28046

Novartis Investigative Site, Madrid

28210

Novartis Investigative Site, Charlotte

30625

Novartis Investigative Site, Hanover

33711

Novartis Investigative Site, St. Petersburg

37075

Novartis Investigative Site, Göttingen

37203

Novartis Investigative Site, Nashville

38119

Novartis Investigative Site, Memphis

40000

Novartis Investigative Site, Shah Alam

40002

Novartis Investigative Site, Khon Kaen

40225

Novartis Investigative Site, Düsseldorf

44000

Novartis Investigative Site, Nantes

44122

Novartis Investigative Site, Cleveland

44195

Novartis Investigative Site, Cleveland

46004

Novartis Investigative Site, Valencia

46280

Novartis Investigative Site, Indianapolis

47150

Novartis Investigative Site, New Albany

48145

Novartis Investigative Site, Münster

50009

Novartis Investigative Site, Zaragoza

55131

Novartis Investigative Site, Mainz

55435

Novartis Investigative Site, Minneapolis

66211

Novartis Investigative Site, Leawood

66215

Novartis Investigative Site, Lenexa

68100

Novartis Investigative Site, Batu Caves

69120

Novartis Investigative Site, Heidelberg

70124

Novartis Investigative Site, Bari

75010

Novartis Investigative Site, Paris

75940

Novartis Investigative Site, Paris

76012

Novartis Investigative Site, Arlington

77025

Novartis Investigative Site, Houston

77030

Novartis Investigative Site, Houston

77401

Novartis Investigative Site, Bellaire

78240

Novartis Investigative Site, San Antonio

78731

Novartis Investigative Site, Austin

78750

Novartis Investigative Site, Austin

79106

Novartis Investigative Site, Freiburg im Breisgau

79606

Novartis Investigative Site, Abilene

80909

Novartis Investigative Site, Colorado Springs

85020

Novartis Investigative Site, Phoenix

89075

Novartis Investigative Site, Ulm

89502

Novartis Investigative Site, Reno

90110

Novartis Investigative Site, Songkhla

92093

Novartis Investigative Site, La Jolla

93053

Novartis Investigative Site, Regensburg

93103

Novartis Investigative Site, Santa Barbara

94000

Novartis Investigative Site, Créteil

94040

Novartis Investigative Site, Mountain View

100044

Novartis Investigative Site, Beijing

100730

Novartis Investigative Site, Beijing

150001

Novartis Investigative Site, Harbin

197022

Novartis Investigative Site, Saint Petersburg

200080

Novartis Investigative Site, Shanghai

214002

Novartis Investigative Site, Wuxi

300020

Novartis Investigative Site, Tianjin

300070

Novartis Investigative Site, Tianjin

325027

Novartis Investigative Site, Wenzhou

400038

Novartis Investigative Site, Chongqing

420066

Novartis Investigative Site, Kazan'

428028

Novartis Investigative Site, Cheboksary

430070

Novartis Investigative Site, Wuhan

510060

Novartis Investigative Site, Guangzhou

515041

Novartis Investigative Site, Shantou

610041

Novartis Investigative Site, Chengdu

620109

Novartis Investigative Site, Yekaterinburg

4941492

Novartis Investigative Site, Petah Tikva

6423906

Novartis Investigative Site, Tel Aviv

7610001

Novartis Investigative Site, Rehovot

9112001

Novartis Investigative Site, Jerusalem

33912-7125

Novartis Investigative Site, Fort Myers

02180

Novartis Investigative Site, Stoneham

07003

Novartis Investigative Site, Bloomfield

53705-3611

Novartis Investigative Site, Madison

T2H0C8

Novartis Investigative Site, Calgary

N6A 4V2

Novartis Investigative Site, London

K1H 8L6

Novartis Investigative Site, Ottawa

K1Z 8R2

Novartis Investigative Site, Ottawa

G1S 4L8

Novartis Investigative Site, Québec

500 05

Novartis Investigative Site, Hradec Králové

532 03

Novartis Investigative Site, Pardubice

100 34

Novartis Investigative Site, Prague

04103

Novartis Investigative Site, Leipzig

711 10

Novartis Investigative Site, Heraklion Crete

411 10

Novartis Investigative Site, Larissa

H 6725

Novartis Investigative Site, Szeged

480-1195

Novartis Investigative Site, Nagakute

963-8052

Novartis Investigative Site, Kōriyama

761-0793

Novartis Investigative Site, Kita-gun

514-8507

Novartis Investigative Site, Tsu

390-8621

Novartis Investigative Site, Matsumoto

852-8501

Novartis Investigative Site, Nagasaki

101-8309

Novartis Investigative Site, Chiyoda-ku

193-0944

Novartis Investigative Site, Hachiōji

111-0051

Novartis Investigative Site, Taito-ku

5022 GC

Novartis Investigative Site, Tilburg

00612

Novartis Investigative Site, Arecibo

08025

Novartis Investigative Site, Barcelona

06100

Novartis Investigative Site, Ankara

IP33 2QZ

Novartis Investigative Site, Bury Saint Edmonds

LS9 7TF

Novartis Investigative Site, Leeds

L7 8XP

Novartis Investigative Site, Liverpool

EC1V 2PD

Novartis Investigative Site, London

NE1 4LP

Novartis Investigative Site, Newcastle upon Tyne

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY