Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery.

PHASE4CompletedINTERVENTIONAL
Enrollment

116

Participants

Timeline

Start Date

June 25, 2019

Primary Completion Date

August 31, 2023

Study Completion Date

August 31, 2023

Conditions
Postoperative Analgesia
Interventions
DRUG

Ropivacaine + Ketamine

Patients will receive subcutaneous wound infiltration with total volume of 24 mL of 0.25% ropivacaine + 1mg/kg ketamine (8 mL per incision) (ketamine group).

DRUG

Ropivacaine + Tramadol

Patients will receive subcutaneous wound infiltration with total volume of 24 mL of 0.25% ropivacaine + 2mg/kg tramadol (8 mL per incision) (Tramadol group).

DRUG

Ropivacaine + Midazolam

Patients will receive subcutaneous wound infiltration with total volume of 24 mL of 0.25% ropivacaine + 50 μg/kg midazolam (8 mL per incision) (Midazolam group).

DRUG

Ropivacaine + Dexmedetomidine

Patients will receive subcutaneous wound infiltration with total volume of 24 mL of 0.25% Ropivacaine + 0.5μg/kg dexmedetomidine (8mL per incision) (Dexmedetomidine group).

DRUG

Ropivacaine + Dexamethasone

Patients will receive subcutaneous wound infiltration with total volume of 24 mL of 0.25% ropivacaine+ 8mg dexamethasone (8 mL per incision) (Dexamethasone group).

DRUG

Ropivacaine

Patients will receive subcutaneous wound infiltration with 24ml of 0.25% Ropivacaine in three divided doses (i.e. 8 mL per incision) (control group). Total dose of Ropivacaine will be 60 mg.

Trial Locations (1)

74800

Aga Khan University Hospital, Karachi

All Listed Sponsors
lead

Aga Khan University

OTHER

NCT03809442 - Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery. | Biotech Hunter | Biotech Hunter