The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

310

Participants

Timeline

Start Date

March 27, 2019

Primary Completion Date

April 30, 2028

Study Completion Date

October 18, 2029

Conditions
Acute-graft-versus-host Disease
Interventions
BIOLOGICAL

AAT

AAT is a lyophilized product for IV administration.

BIOLOGICAL

Placebo

Albumin solution administered intravenously

Trial Locations (34)

4029

RECRUITING

Royal Brisbane and Women's Hospital, Herston

21565

RECRUITING

Gachon University Gil Medical Center, Incheon

22903

RECRUITING

University of Virginia Health System, Charlottesville

27705

COMPLETED

Duke University Medical Center, Durham

30322

RECRUITING

Emory University, Atlanta

33701

RECRUITING

Johns Hopkins Hospital, St. Petersburg

37007

RECRUITING

Salamanca University Hospital, Salamanca

39008

RECRUITING

Marqués de Valdecilla University Hospital, Barcelona

44106

RECRUITING

University Hospital Cleveland Medical Center, Cleveland

44280

COMPLETED

Turgut Ozal Medicine Center, Battalgazi

48108

RECRUITING

INJE University Haeundae Paik Hospital, Busan

48109

RECRUITING

University of Michigan Medical Center, Ann Arbor

49241

ACTIVE_NOT_RECRUITING

Pusan National University Hospital, Busan

50937

RECRUITING

Uniklinik Köln, lnnere Mediz, Cologne

66205

RECRUITING

University of Kansas Cancer Center, Westwood

77030

ACTIVE_NOT_RECRUITING

The University of Texas-MD Anderson Cancer Center, San Antonio

84113

ACTIVE_NOT_RECRUITING

University of Utah Primary Children's Hospital, Salt Lake City

85258

ACTIVE_NOT_RECRUITING

HonorHealth Scottsdale Shea Medical Center, Scottsdale

89133

RECRUITING

Grande Ospedale Metropolitano Bianchi-Melacrino-Morelli, Calabria

95123

RECRUITING

University Hospital Catania, Calabria

98109

RECRUITING

Fred Hutchinson Cancer Research Center, Seattle

1138677

RECRUITING

Tokyo Metropolitan Komagome Hospital, Bunkyō City

4538511

RECRUITING

Aichi Medical Center Nagoya Daiichi Hospital, Nagoya

4668550

RECRUITING

Nagoya University Hospital, Nagoya

4668602

RECRUITING

Anjo Kosei Hospital, Anjo-shi

5418567

RECRUITING

Osaka International Cancer Institute, Osaka

5458586

RECRUITING

Osaka Metropolitan University Hospital, Osaka

7348551

RECRUITING

Hiroshima University Kasumi Campus, Hiroshima

71008558

COMPLETED

Okayama University Hospital, Okayama

02215

RECRUITING

Dana Farber Cancer Institute, Boston

0608648

RECRUITING

Hokkaido University Hospital, Sapporo

03080

RECRUITING

Seoul National University Hospital, Seoul

08035

RECRUITING

Hospital Universitario Valle de Hebron, Barcelona

06200

RECRUITING

Ankara Abdurrahman Yurtaslan, Ankara

Sponsors

Lead Sponsor

All Listed Sponsors
lead

CSL Behring

INDUSTRY