Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation

NACompletedINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

June 14, 2018

Primary Completion Date

October 11, 2018

Study Completion Date

November 1, 2018

Conditions
Lung Cancer
Interventions
DEVICE

compliance guided an optimal Positive End-Expiratory Pressure

The study groups received an alveolar recruitment maneuver(increase inspiratory pressure to 30cmH2O for 10s) at the 10min after one-lung ventilation. After the alveolar recruitment maneuver,the study group titrate PEEP from 4cmH2O,increased in 2cmH2O steps and hold at each step for 1min,and the static pulmonary compliance(Cst) would be record.Optimal PEEP was determined until the maximal static pulmonary compliance was obtained.

DEVICE

PEEP level of 5 cmH2O

In the control group at PEEP level of 5 cmH2O was established and maintained during the study period

Trial Locations (1)

Unknown

FujianUnionHospital, Fuzhou

All Listed Sponsors
lead

Fujian Medical University Union Hospital

OTHER

NCT03804398 - Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation | Biotech Hunter | Biotech Hunter