26
Participants
Start Date
October 28, 2019
Primary Completion Date
October 26, 2021
Study Completion Date
September 4, 2025
Accelerated Hypofractionated Radiation Therapy
160 Gy given as one 4 Gy fraction per day, 5 days per week for 15 fractions.
Biospecimen Collection
Undergo collection of blood samples
Computed Tomography
Undergo brain CT and chest CT
Durvalumab
Administered intravenously (IV) as a 1500 mg fixed dose over 60 minutes for 13 cycles (1 cycle = 4 weeks), until disease progression or toxicity or death, whichever comes first.
Magnetic Resonance Imaging of the Brain with and without Contrast
Undergo brain MRI
Monalizumab
Administered IV as a 1500 mg fixed dose over 60 minutes (+/- 10 minutes)
Oleclumab
Administered IV 3000 mg over 60 minutes (+/- 10 minutes)
Radiation Therapy
60 gy given as one 2 Gy fraction per day, 5 days per week for 30 fractions
Lankenau Medical Center, Wynnewood
Thomas Jefferson University Hospital, Philadelphia
UM Upper Chesapeake Medical Center, Bel Air
Central Maryland Radiation Oncology in Howard County, Columbia
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie
University of Maryland/Greenebaum Cancer Center, Baltimore
West Virginia University Healthcare, Morgantown
Grady Health System, Atlanta
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Augusta University Medical Center, Augusta
Saint Elizabeth Healthcare Edgewood, Edgewood
Ohio State University Comprehensive Cancer Center, Columbus
McLaren Cancer Institute-Macomb, Mount Clemens
McLaren-Port Huron, Port Huron
Michigan Healthcare Professionals Troy, Troy
Wayne State University/Karmanos Cancer Institute, Detroit
Michigan Healthcare Professionals Farmington, Farmington Hills
Weisberg Cancer Treatment Center, Farmington Hills
McLaren Cancer Institute-Clarkston, Clarkston
Michigan Healthcare Professionals Clarkston, Clarkston
McLaren Cancer Institute-Lapeer Region, Lapeer
McLaren Cancer Institute-Flint, Flint
Singh and Arora Hematology Oncology PC, Flint
McLaren Cancer Institute-Bay City, Bay City
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing
Mid-Michigan Physicians-Lansing, Lansing
McLaren Cancer Institute-Northern Michigan, Petoskey
Benefis Sletten Cancer Institute, Great Falls
Logan Health Medical Center, Kalispell
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at Christian Hospital, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City
University of Kansas Cancer Center - North, Kansas City
University of Kansas Cancer Center-West, Kansas City
University of Kansas Cancer Center, Kansas City
University of Kansas Hospital-Westwood Cancer Center, Westwood
University of Kansas Cancer Center-Overland Park, Overland Park
Nebraska Methodist Hospital, Omaha
University of Oklahoma Health Sciences Center, Oklahoma City
M D Anderson Cancer Center, Houston
MD Anderson West Houston, Houston
MD Anderson in The Woodlands, Conroe
MD Anderson in Sugar Land, Sugar Land
MD Anderson League City, League City
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
Saint Alphonsus Cancer Care Center-Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Legacy Mount Hood Medical Center, Gresham
Legacy Good Samaritan Hospital and Medical Center, Portland
Legacy Salmon Creek Hospital, Vancouver
Collaborators (1)
NRG Oncology
OTHER
National Cancer Institute (NCI)
NIH