300
Participants
Start Date
March 15, 2019
Primary Completion Date
December 21, 2026
Study Completion Date
December 21, 2031
Carboplatin
Given IV
Esophagectomy
Undergo esophagectomy
Intensity-Modulated Radiation Therapy
Undergo IMRT
Paclitaxel
Given IV
Proton Beam Radiation Therapy
Undergo PBT
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
FOLFOX regimen
Folinic acid, flurouracil and oxaliplatin
CAPOX regimen
Capecitabine combined with oxaliplatin
Docetaxel
Chemotherapy
5FU
Chemotherapy
RECRUITING
New York Proton Center, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Memorial Sloan Kettering Westchester, Harrison
RECRUITING
Memorial Sloan Kettering Nassau, Uniondale
RECRUITING
Memorial Sloan Kettering Commack, Commack
RECRUITING
University of Pennsylvania/Abramson Cancer Center, Philadelphia
ACTIVE_NOT_RECRUITING
Inova Loudoun Hospital, Leesburg
RECRUITING
UM Upper Chesapeake Medical Center, Bel Air
RECRUITING
Maryland Proton Treatment Center, Baltimore
RECRUITING
University of Maryland/Greenebaum Cancer Center, Baltimore
ACTIVE_NOT_RECRUITING
Inova Schar Cancer Institute, Fairfax
ACTIVE_NOT_RECRUITING
Inova Fair Oaks Hospital, Fairfax
ACTIVE_NOT_RECRUITING
Inova Alexandria Hospital, Alexandria
ACTIVE_NOT_RECRUITING
Emory Proton Therapy Center, Atlanta
ACTIVE_NOT_RECRUITING
Emory University Hospital Midtown, Atlanta
ACTIVE_NOT_RECRUITING
Emory University Hospital/Winship Cancer Institute, Atlanta
ACTIVE_NOT_RECRUITING
Emory Saint Joseph's Hospital, Atlanta
ACTIVE_NOT_RECRUITING
Orlando Health Cancer Institute, Orlando
RECRUITING
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
RECRUITING
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables
RECRUITING
Miami Cancer Institute, Miami
RECRUITING
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
SUSPENDED
Thompson Oncology Group-Maryville, Maryville
RECRUITING
Thompson Oncology Group-Oak Ridge, Oak Ridge
RECRUITING
Thompson Proton Center, Knoxville
RECRUITING
Thompson Cancer Survival Center, Knoxville
RECRUITING
Thompson Cancer Survival Center - West, Knoxville
RECRUITING
UH Seidman Cancer Center at UH Avon Health Center, Avon
RECRUITING
Geauga Hospital, Chardon
SUSPENDED
Mercy Cancer Center-Elyria, Elyria
RECRUITING
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
RECRUITING
Case Western Reserve University, Cleveland
RECRUITING
UHHS-Chagrin Highlands Medical Center, Beachwood
RECRUITING
UH Seidman Cancer Center at Landerbrook Health Center, Mayfield Heights
RECRUITING
University Hospitals Parma Medical Center, Parma
RECRUITING
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights
SUSPENDED
UH Seidman Cancer Center at Saint John Medical Center, Westlake
RECRUITING
UHHS-Westlake Medical Center, Westlake
RECRUITING
University Hospitals Portage Medical Center, Ravenna
RECRUITING
University Hospitals Sharon Health Center, Wadsworth
RECRUITING
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky
RECRUITING
University of Cincinnati Cancer Center-West Chester, West Chester
RECRUITING
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
RECRUITING
Corewell Health William Beaumont University Hospital, Royal Oak
RECRUITING
Corewell Health Beaumont Troy Hospital, Troy
RECRUITING
Corewell Health Dearborn Hospital, Dearborn
RECRUITING
Wayne State University/Karmanos Cancer Institute, Detroit
RECRUITING
Weisberg Cancer Treatment Center, Farmington Hills
RECRUITING
McLaren Cancer Institute-Lapeer Region, Lapeer
RECRUITING
McLaren Cancer Institute-Flint, Flint
RECRUITING
McLaren Cancer Institute-Bay City, Bay City
RECRUITING
McLaren Cancer Institute-Owosso, Owosso
RECRUITING
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing
COMPLETED
Mayo Clinic Health System-Eau Claire Clinic, Eau Claire
RECRUITING
Mayo Clinic Radiation Therapy-Northfield, Northfield
RECRUITING
Minnesota Oncology Hematology PA-Maplewood, Maplewood
RECRUITING
Ridgeview Medical Center, Waconia
RECRUITING
Hennepin County Medical Center, Minneapolis
ACTIVE_NOT_RECRUITING
Unity Hospital, Fridley
RECRUITING
Mercy Hospital, Coon Rapids
ACTIVE_NOT_RECRUITING
Mayo Clinic in Rochester, Rochester
COMPLETED
Mayo Clinic Health Systems-Mankato, Mankato
COMPLETED
Mayo Clinic Health System in Albert Lea, Albert Lea
RECRUITING
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
RECRUITING
Northwestern Medicine Cancer Center Delnor, Geneva
RECRUITING
Northwestern Medicine Cancer Center Warrenville, Warrenville
RECRUITING
Alton Memorial Hospital, Alton
RECRUITING
Memorial Hospital East, Shiloh
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Siteman Cancer Center-South County, St Louis
RECRUITING
Siteman Cancer Center at Christian Hospital, St Louis
RECRUITING
Siteman Cancer Center at West County Hospital, Creve Coeur
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
RECRUITING
Mercy Hospital Springfield, Springfield
RECRUITING
University of Arkansas for Medical Sciences, Little Rock
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
M D Anderson Cancer Center, Houston
RECRUITING
MD Anderson West Houston, Houston
RECRUITING
MD Anderson in The Woodlands, Conroe
RECRUITING
MD Anderson in Sugar Land, Sugar Land
RECRUITING
MD Anderson League City, League City
RECRUITING
Huntsman Cancer Institute/University of Utah, Salt Lake City
RECRUITING
Mayo Clinic Hospital in Arizona, Phoenix
ACTIVE_NOT_RECRUITING
Mayo Clinic in Arizona, Scottsdale
ACTIVE_NOT_RECRUITING
University of Washington Medical Center - Montlake, Seattle
RECRUITING
Massachusetts General Hospital Cancer Center, Boston
RECRUITING
Memorial Sloan Kettering Basking Ridge, Basking Ridge
RECRUITING
Memorial Sloan Kettering Monmouth, Middletown
RECRUITING
Memorial Sloan Kettering Bergen, Montvale
Lead Sponsor
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER