139
Participants
Start Date
February 13, 2018
Primary Completion Date
March 16, 2022
Study Completion Date
March 16, 2022
Ipatasertib
Ipatasertib will be administered at a dose of 400 milligrams (mg) orally daily on Days 1-21 of each 28 day cycle for all arms except for arms F1/F2 where it will be administered at a dose of 300 milligrams (mg) orally daily for the first two cycles and 400 mg for the remaining three cycles.
Paclitaxel
Paclitaxel will be administered at a dose of 80 milligrams per square meter (mg/m\^2) as IV infusion on Days 1, 8, and 15 of each 28 day cycle for all arms, with the exceptions of Arms F1, F2, G1 and G2, where it will be also administered on Day 22 as well, of each 28 day cycle.
Atezolizumab
Atezolizumab will be administered by IV infusion at a fixed dose of 840 mg on Days 1 and 15 of each 28 day cycle for all arms, although in Arms C1/C2, it will be administered on Day 15 of Cycle 1 followed by Days 1 and 15 in subsequent cycles.
Nab-Paclitaxel
Nab-paclitaxel will be administered by IV infusion at a dose of 100 mg/m\^2 on Days 1, 8, and 15 of each 28 day cycle.
AC
AC (Doxorubicin and Cyclophosphamide) will be administered by IV infusion at 60 mg/m\^2 and 600 mg/m\^2 respectively on Days 1 and 15 of Cycles 1 and 2 for Arms F1, F2, G1 and G2.
St Vincents Hospital; Cardiopulmonary transplant Ambulatory Care Dept, Darlinghurst
Peter MacCallum Cancer Center, North Melbourne
Austin Hospital, Heidelberg
Hospital de la Santa Creu i Sant Pau, Barcelona
Centre Georges Francois Leclerc, Dijon
Hospital Clinico San Carlos; Servicio de Oncologia, Madrid
Hospital Universitario Fundacion Jimenez Diaz., Madrid
Hospital Universitario 12 de Octubre, Madrid
Centro Integral Oncologico Clara Campal (CIOCC); Dirección Médica, Madrid
Institut Bergonie, Bordeaux
Hospital Universitario Virgen del Rocío, Seville
Institut de Cancerologie de l Ouest, Angers
Institut Curie, Paris
Pacific Shores Medical Group, Long Beach
Gustave Roussy, Villejuif
Hospital Universitario La Paz, Madrid
Barts Cancer Institute, London
Nottingham University Hospitals NHS Trust, Nottingham
Hoffmann-La Roche
INDUSTRY