NCT03798626 - Gevokizumab With Standard of Care Anti-cancer Therapies for Metastatic Colorectal, Gastroesophageal, and Renal Cancers | Biotech Hunter

Enrollment

167

Participants

Timeline

Start Date

May 22, 2019

Primary Completion Date

March 1, 2023

Study Completion Date

February 5, 2025

Conditions

Colorectal CancerGastroesophageal CancerRenal Cell Carcinoma

Interventions

DRUG

Gevokizumab

60 mg/mL concentration; administered intravenously (IV)

DRUG

Bevacizumab

25 mg/mL concentration; administered IV

DRUG

Modified FOLFOX6

Oxaliplatin \[5 mg/mL concentration; administered IV\], leucovorin \[10 mg/mL concentration; administered IV\] (or levoleucovorin \[10 mg/mL concentration; administered IV\]), and 5-fluorouracil \[50 mg/mL concentration; administered IV\]

DRUG

FOLFIRI

Irinotecan \[20 mg/mL concentration; administered IV\], leucovorin \[10 mg/mL concentration; administered IV\] (or levoleucovorin \[10 mg/mL concentration; administered IV\]), and 5-fluorouracil \[50 mg/mL concentration; administered IV\]

DRUG

Ramucirumab

10 mg/mL concentration; administered IV

DRUG

Paclitaxel

6 mg/mL concentration; administered IV

DRUG

Cabozantinib

60 mg tablet; administered orally

Trial Locations (34)

1000

Novartis Investigative Site, Brussels

2650

Novartis Investigative Site, Edegem

3000

Novartis Investigative Site, Melbourne

Novartis Investigative Site, Leuven

20089

Novartis Investigative Site, Rozzano

20162

Novartis Investigative Site, Milan

28009

Novartis Investigative Site, Madrid

28034

Novartis Investigative Site, Madrid

28050

Novartis Investigative Site, Madrid

37203

Sarah Cannon Research Institute, Nashville

41013

Novartis Investigative Site, Seville

46010

Novartis Investigative Site, Valencia

60488

Novartis Investigative Site, Frankfurt am Main

63110

WA Uni School Of Med, St Louis

70403

Novartis Investigative Site, Tainan City

89081

Novartis Investigative Site, Ulm

90095

University of California LA, Los Angeles

119074

Novartis Investigative Site, Singapore

5265601

Novartis Investigative Site, Ramat Gan

6423906

Novartis Investigative Site, Tel Aviv

8330074

Novartis Investigative Site, Santiago

T2N 4N2

Novartis Investigative Site, Calgary

M5G 2M9

Novartis Investigative Site, Toronto

656 53

Novartis Investigative Site, Brno

01307

Novartis Investigative Site, Dresden

464 8681

Novartis Investigative Site, Nagoya

277 8577

Novartis Investigative Site, Kashiwa

541-8567

Novartis Investigative Site, Osaka

411 8777

Novartis Investigative Site, Sunto Gun

113-8603

Novartis Investigative Site, Bunkyo-ku

05505

Novartis Investigative Site, Seoul

08907

Novartis Investigative Site, L'Hospitalet de Llobregat

SW3 6JJ

Novartis Investigative Site, London

M20 2BX

Novartis Investigative Site, Manchester