Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

PHASE2CompletedINTERVENTIONAL
Enrollment

603

Participants

Timeline

Start Date

February 12, 2019

Primary Completion Date

October 28, 2024

Study Completion Date

October 28, 2024

Conditions
Advanced Solid TumorsTriple Negative Breast CancerOvarian CancerGastric CancerColorectal CancerGlioblastomaBiliary Tract CancersPancreatic Cancer
Interventions
BIOLOGICAL

Pembrolizumab

Administered as an IV infusion on Day 1 Q3W.

DRUG

Lenvatinib

Administered orally once a day during each 21-day cycle.

Trial Locations (88)

704

National Cheng Kung University Hospital ( Site 3003), Tainan City

1118

Hospital Aleman ( Site 2100), Buenos Aires

1211

Hopitaux Universitaires de Geneve HUG ( Site 1701), Geneva

3004

Alfred Health ( Site 0902), Melbourne

3010

Inselspital Universitaetsspital Bern ( Site 1705), Bern

4029

Royal Brisbane and Women s Hospital ( Site 0901), Herston

6009

Sir Charles Gairdner Hospital ( Site 0903), Nedlands

6500

Ospedale Regionale di Bellinzona e Valli ( Site 1703), Bellinzona

7000

Kantonsspital Graubuenden ( Site 1704), Chur

8091

Universitaetsspital Zurich ( Site 1700), Zurich

9007

Kantonsspital St. Gallen ( Site 1702), Sankt Gallen

10002

National Taiwan University Hospital ( Site 3000), Taipei

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0023), New York

10330

Chulalongkorn University ( Site 5001), Bangkok

10400

Ramathibodi Hospital. ( Site 5002), Bangkok

10700

Siriraj Hospital ( Site 5003), Bangkok

18103

Lehigh Valley Hospital- Cedar Crest ( Site 0047), Allentown

28009

Hospital Universitario Gregorio Maranon ( Site 0701), Madrid

28027

Clinica Universitaria de Navarra ( Site 0704), Madrid

28034

Hospital Ramon y Cajal ( Site 0702), Madrid

31059

Institut Claudius Regaud IUCT Oncopole ( Site 0403), Toulouse

32806

University of Florida-Health Cancer Center-Orlando ( Site 0015), Orlando

38138

West Cancer Center - East Campus ( Site 0018), Germantown

44805

Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 0402), Saint-Herblain

53100

Policlinico Le Scotte - A.O. Senese ( Site 1401), Siena

57104

Sanford Cancer Center ( Site 0058), Sioux Falls

58102

Sanford Fargo Medical Center ( Site 0059), Fargo

59000

Centre Oscar Lambret ( Site 0401), Lille

60528

Universitaetsklinikum Frankfurt ( Site 0306), Frankfurt am Main

65199

HELIOS Dr. Horst Schmidt Kliniken Wiesbaden ( Site 0301), Wiesbaden

69373

Centre Leon Berard ( Site 0405), Lyon

70376

Robert Bosch GmbH ( Site 0307), Stuttgart

75230

Mary Crowley Cancer Research Centers - Medical City Hospital ( Site 0049), Dallas

80045

University of Colorado, Anschutz Cancer Pavilion ( Site 0007), Aurora

80131

Istituto Nazionale Tumori Fondazione Pascale ( Site 1400), Napoli

90048

Cedars Sinai Medical Center ( Site 0003), Los Angeles

91010

City of Hope ( Site 0002), Duarte

93053

Universitaetsklinikum Regensburg ( Site 0304), Regensburg

94800

Institut Gustave Roussy ( Site 0400), Villejuif

95817

University of California Davis Comprehensive Cancer Center ( Site 0005), Sacramento

98104

Swedish Medical Center ( Site 0021), Seattle

110321

Instituto Nacional de Cancerologia E.S.E ( Site 1102), Bogotá

115478

Russian Oncological Research Center n.a. N.N. Blokhin ( Site 1604), Moscow

163045

Arkhangelsk Clinical Oncological Dispensary ( Site 1600), Arkhangelsk

188663

Leningrad Regional Oncology Center ( Site 1609), Saint Petersburg

197758

Scientific Research Oncology Institute n.a. N.N.Petrov ( Site 1610), Saint Petersburg

198255

City Clinical Oncology Center ( Site 1608), Saint Petersburg

420029

Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1603), Kazan'

660001

Oncologos del Occidente S.A. ( Site 1106), Pereira

760032

Fundacion Valle del Lili ( Site 1101), Santiago de Cali

3109601

Rambam Medical Center ( Site 0602), Haifa

4780000

Centro Investigación del Cáncer James Lind ( Site 1203), Temuco

5262000

Chaim Sheba Medical Center ( Site 0600), Ramat Gan

6423906

Sourasky Medical Center ( Site 0603), Tel Aviv

7500921

Fundacion Arturo Lopez Perez ( Site 1201), Santiago

8330024

Pontificia Universidad Catolica de Chile ( Site 1202), Santiago

8380456

Hospital Clinico Universidad de Chile ( Site 1200), Santiago

8457108

Soroka Medical Center ( Site 0601), Beersheba

9112001

Hadassah Ein Kerem Medical Center ( Site 0604), Jerusalem

08901

Rutgers Cancer Institute of New Jersey ( Site 0009), New Brunswick

53792-0001

University of Wisconsin Carbone Cancer Center ( Site 0017), Madison

C1078AAI

Fundacion Favaloro para la Docencia e Investigacion Medica ( Site 2106), Ciudad Autonoma de Buenos Aires

C1280AEB

Hospital Britanico de Buenos Aires ( Site 2109), Ciudad de Buenos Aires

S2000KZE

Instituto de Oncologia de Rosario ( Site 2105), Rosario

C1431FWO

CEMIC ( Site 2104), Buenos Aires

C1012AAR

IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 2101), Caba

V2S 0C2

BC Cancer - Abbotsford ( Site 0200), Abbotsford

R3E 0V9

CancerCare Manitoba ( Site 0201), Winnipeg

L8V 4X2

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0208), Hamilton

M4N 3M5

Sunnybrook Research Institute ( Site 0207), Toronto

M5G 2M9

Princess Margaret Cancer Centre ( Site 0202), Toronto

H2X 3E4

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0210), Montreal

G1R 2J6

CHU de Quebec Universite de Laval ( Site 0206), Québec

050030

Fundacion Colombiana de Cancerologia Clinica Vida ( Site 1105), Medellín

06189

Centre Antoine Lacassagne ( Site 0404), Nice

07548

SRH Wald-Klinikum Gera GmbH ( Site 0309), Gera

07740

Universitaetsklinikum Jena ( Site 0302), Jena

Unknown

Istituto Clinico Humanitas Research Hospital ( Site 1402), Rozzano

00168

Fondazione Policlinico Universitario A. Gemelli ( Site 1403), Roma

05505

Asan Medical Center ( Site 1002), Songpagu

03080

Seoul National University Hospital ( Site 1000), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 1001), Seoul

08036

Hospital Clinic i Provincial ( Site 0703), Barcelona

CB2 0QQ

Cambridge University Hospitals NHS Trust ( Site 0803), Cambridge

LE1 5WW

Leicester Royal Infirmary. Univ. Hosp. of Leicester NHS Trust ( Site 0804), Leicester

SE1 9RT

Guy's Hospital ( Site 0806), London

SM3 5PT

Royal Marsden Hospital (Sutton) ( Site 0800), London

M20 4BX

Christie NHS Foundation Trust ( Site 0805), Manchester

All Listed Sponsors
collaborator

Eisai Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03797326 - Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005) | Biotech Hunter | Biotech Hunter