Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis

PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 1, 2019

Primary Completion Date

March 4, 2020

Study Completion Date

April 4, 2020

Conditions
Ulcerative ColitisInflammatory Bowel DiseasesAcute Severe Colitis
Interventions
DRUG

Ceftriaxone

Injection ceftriaxone 1 gm will be prepared by reconstitution of the crystallised powder form in 100 ml of normal saline. This preparation will then be infused slowly over thirty minutes, after intradermal testing for hypersensitivity. Inj ceftriaxone 1gm IV will be given twelve hourly.

DRUG

Metronidazole

Injection metronidazole 500 mg is available from pharmacies in solutions of 100 ml. It will be infused slowly over thirty minutes, three times per day

OTHER

Placebo infusion

Similar placebo infusion

Trial Locations (1)

160012

Postgraduate Institute of Medical Education and Research, Chandigarh

All Listed Sponsors
lead

Post Graduate Institute of Medical Education and Research, Chandigarh

OTHER

NCT03794765 - Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis | Biotech Hunter | Biotech Hunter