94
Participants
Start Date
July 8, 2019
Primary Completion Date
March 31, 2025
Study Completion Date
April 7, 2026
Dinutuximab
Given IV
Eflornithine Hydrochloride
Given PO or via NG or G tube
Irinotecan Hydrochloride
Given IV
Sargramostim
Given SC or IV
Temozolomide
Given PO or via NG or G tube
Starship Children's Hospital, Grafton
Sydney Children's Hospital, Randwick
The Children's Hospital at Westmead, Westmead
John Hunter Children's Hospital, Hunter Regional Mail Centre
Royal Children's Hospital, Parkville
Queensland Children's Hospital, South Brisbane
Women's and Children's Hospital-Adelaide, North Adelaide
Perth Children's Hospital, Perth
Christchurch Hospital, Christchurch
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
NYU Langone Hospital - Long Island, Mineola
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Lehigh Valley Hospital-Cedar Crest, Allentown
Children's Hospital of Philadelphia, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
University of Maryland/Greenebaum Cancer Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
University of Virginia Cancer Center, Charlottesville
Children's Hospital of The King's Daughters, Norfolk
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
Duke University Medical Center, Durham
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Prisma Health Richland Hospital, Columbia
BI-LO Charities Children's Cancer Center, Greenville
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
University of Florida Health Science Center - Gainesville, Gainesville
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Saint Mary's Medical Center, West Palm Beach
Johns Hopkins All Children's Hospital, St. Petersburg
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
C S Mott Children's Hospital, Ann Arbor
Children's Hospital of Michigan, Detroit
Wayne State University/Karmanos Cancer Institute, Detroit
Michigan State University Clinical Center, East Lansing
Bronson Methodist Hospital, Kalamazoo
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Blank Children's Hospital, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Loyola University Medical Center, Maywood
Lurie Children's Hospital-Chicago, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
University Medical Center of Southern Nevada, Las Vegas
Sunrise Hospital and Medical Center, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Renown Regional Medical Center, Reno
Children's Hospital Los Angeles, Los Angeles
Cedars Sinai Medical Center, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Miller Children's and Women's Hospital Long Beach, Long Beach
Rady Children's Hospital - San Diego, San Diego
Children's Hospital of Orange County, Orange
Valley Children's Hospital, Madera
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
Kaiser Permanente-Oakland, Oakland
University of California Davis Comprehensive Cancer Center, Sacramento
Kapiolani Medical Center for Women and Children, Honolulu
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Mary Bridge Children's Hospital and Health Center, Tacoma
Madigan Army Medical Center, Tacoma
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Yale University, New Haven
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Dana-Farber Cancer Institute, Boston
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Vermont and State Agricultural College, Burlington
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Kingston Health Sciences Centre, Kingston
Children's Hospital, London
Hospital for Sick Children, Toronto
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
HIMA San Pablo Oncologic Hospital, Caguas
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK