NCT03793114View on ClinicalTrials.gov

Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease

NAActive, not recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

September 26, 2018

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Primary Adrenal Insufficiency
Interventions
DIAGNOSTIC_TEST

Cosyntropin stimulation test

Blood samples are taken before (0 min), and 30 and 60 min after intravenously administration of 250 µg cosyntropin (tetracosactide acetate) with the patient placed in the recumbent position. The test will be performed non-fasting (but medication-fasting) between 08:00 and 10:00 a.m.

DIAGNOSTIC_TEST

Baseline blood tests

Medication-fasting morning levels of adrenocortical hormones.

DEVICE

30-hour ambulatory sampling of intestinal fluid

30-hour ambulatory sampling of intestinal fluid for analysis of adrenocortical hormones.

OTHER

Blood test

Cardiovascular and inflammatory biomarker profiles

Trial Locations (3)

5021

Haukeland University Hospital, Bergen

10627

Endokrinologie in Charlottenburg, Berlin

171 77

Karolinska Institutet, Stockholm

All Listed Sponsors
collaborator

Karolinska Institutet

OTHER

collaborator

Charite University, Berlin, Germany

OTHER

lead

University of Bergen

OTHER

NCT03793114 - Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease | Biotech Hunter | Biotech Hunter