104
Participants
Start Date
January 17, 2019
Primary Completion Date
March 19, 2025
Study Completion Date
March 19, 2025
Hydroxyurea
The alternative arm will use PK data to choose a starting hydroxyurea dose to achieve an AUC of 115 mg\*h/L to approximate maximum tolerated dose. On the standard arm, participants will start at the traditional, weight-based dose of 20 mg/kg/day. Following selection of the starting dose, all participants will follow the same dose escalation and laboratory monitoring procedures.
Cohen Children's Medical Center/Northwell Health, New Hyde Park
Children's Healthcare of Atlanta, Atlanta
Nationwide Children's Hospital., Columbus
Rainbow Babies / University Hospitals Cleveland Medical Center, Cleveland
Cincinnati Children's Hospital Medical Center, Cincinnati
Riley Hospital for Children at Indiana University Health, Indianapolis
Indiana Hemophilia & Thrombosis Center, Inc. (IHTC), Indianapolis
Children's Hospital of Wisconsin, Milwaukee
Children's Hospitals and Clinics of Minnesota, Minneapolis
Children's Hospital of Illinois, Peoria
Carle Foundation Hospital, Urbana
Phoenix Children's Hospital, Phoenix
Boston Children's Hospital, Boston
Doris Duke Charitable Foundation
OTHER
Lifespan
OTHER