Stress, Sex, and the Generalization of Fear

NACompletedINTERVENTIONAL
Enrollment

606

Participants

Timeline

Start Date

January 25, 2019

Primary Completion Date

June 30, 2022

Study Completion Date

June 30, 2022

Conditions
Psychological Stress
Interventions
BEHAVIORAL

Stress immediately before learning in males

Male participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning.

BEHAVIORAL

Sham control immediately before learning in males

Male participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning.

BEHAVIORAL

Stress 30 minutes before learning in males

Male participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning.

BEHAVIORAL

Sham control 30 minutes before learning in males

Male participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning.

BEHAVIORAL

Stress immediately before learning in females

Female participants will be exposed to the socially evaluated cold pressor test immediately prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Immediately following the acute stressor, participants will undergo the acquisition phase of fear conditioning.

BEHAVIORAL

Sham control immediately before learning in females

Female participants will be exposed to the sham control condition (no stress) immediately prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Immediately following the sham control condition, participants will undergo the acquisition phase of fear conditioning.

BEHAVIORAL

Stress 30 minutes before learning in females

Female participants will be exposed to the socially evaluated cold pressor test 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of ice cold water for up to 3 minutes. The participants will also be informed that they are being videotaped for analysis of facial expressions and be asked to stare at a camera throughout the manipulation. Thirty minutes following the acute stressor, participants will undergo the acquisition phase of fear conditioning.

BEHAVIORAL

Sham control 30 minutes before learning in females

Female participants will be exposed to the sham control condition (no stress) 30 minutes prior to fear learning. Participants will place their dominant hand in a bath of lukewarm water for up to 3 minutes. Thirty minutes following the sham control condition, participants will undergo the acquisition phase of fear conditioning.

Trial Locations (1)

45810

Ohio Northern University, Ada

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Ohio Northern University

OTHER

NCT03786952 - Stress, Sex, and the Generalization of Fear | Biotech Hunter | Biotech Hunter