Safety and Efficacy of Tisotumab Vedotin Monotherapy & in Combination With Other Cancer Agents in Subjects With Cervical Cancer

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

214

Participants

Timeline

Start Date

February 27, 2019

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Cervical Cancer
Interventions
DRUG

Tisotumab Vedotin

Given into the vein (IV)

DRUG

Bevacizumab

Given via IV

DRUG

Pembrolizumab

Given via IV

DRUG

Carboplatin

Given via IV

Trial Locations (71)

1200

Cliniques universitaires Saint-Luc, Brussels

2650

Universitair Ziekenhuis Antwerpen (UZA), Edegem

3000

UZ Leuven, Leuven

3015

Erasmus University Medical Center Rotterdam, Rotterdam

3584

University Medical Center Utrecht (UMC Utrecht), Utrecht

4000

Centre Hospitalier Universitaire (CHU) de Liège, Liège

5000

CHU UCL Namur, Namur

Sainte-Elisabeth, Namur

5072

Rigshospitalet, Copenhagen

6000

Grand Hôpital de Charleroi, Charleroi

6280

Grand Hôpital de Charleroi, Loverval

6800

Centre Hospitalier de l'Ardenne, Libramont

8000

AZ Sint-Jan, Bruges

8035

Hospital Universitari Vall d'Hebron, Barcelona

9000

Universitair Ziekenhuis Gent, Ghent

10065

Memorial Sloan Kettering Cancer Center, New York

11203

SUNY Downstate Medical Center, Brooklyn

12851

Vseobecna fakultni nemocnice v Praze, Prague

14004

Hospital Universitario Reina Sofia, Córdoba

15213

Magee-Womens Hospital of UPMC, Pittsburgh

18081

Nemocnice Na Bulovce, Prague

19111

Fox Chase Cancer Center, Philadelphia

20141

IEO Istituto Europeo di Oncologia, Milan

24016

Carilion Clinic, Roanoke

27514

University of North Carolina Chapel Hill, Chapel Hill

28041

Hospital 12 De Octubre, Madrid

29607

St Francis Hospital Cancer Center, Greenville

30120

Hospital Universitario Virgen de la Arrixaca, El Palmar

30912

Augusta University, Augusta

32207

Baptist MD Anderson Cancer Center, Jacksonville

43026

Ohio State University Wexner Medical Center, Hilliard

44106

Cleveland Clinic, Cleveland

44195

Cleveland Clinic, Cleveland

45206

University of Cincinnati Physicians Group, Cincinnati

46202

Indiana University School of Medicine, Indianapolis

59101

Billings Clinic Cancer Center, Billings

59102

Montana Cancer Consortium, Billings

60525

University of Chicago, Chicago

66205

University of Kansas Medical Center, Westwood

70121

Oschner Clinic, New Orleans

70852

Fakultni nemocnice Ostrava, Ostrava-Poruba

77520

Fakultni nemocnice Olomouc, Olomouc

80131

Istituto Nazionale Tumori Fondazione G. Pascale, Napoli

84112

Huntsman Cancer Center, Salt Lake City

85016

Arizona Oncology Associates, Phoenix

91342

Olive View - UCLA Research and Education Institute, Sylmar

92868

Univ California, Irvine Medical Center, Orange

95100

Azienda Ospedaliera Cannizzaro, Catania

02215

Dana-Farber Cancer Institute, Boston

02905

Brown University - Women's and Infant Hospital, Providence

Unknown

Universitaire Ziekenhuizen Leuven,, Leuven

Cork University Hospital, Cork

University Hospital Waterford, Waterford

AMC Medical Research, Amsterdam

775 20

Fakultni nemocnice Olomouc, Olomouc

128 51

Vseobecna fakultni nemocnice v Praze, Prague

180 81

Fakultni nemocnice Bulovka, Prague

D07 R2WY

Mater Misericordiae University Hospital, Dublin

X91 ER8E

Waterford Regional Hospital, Waterford

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome

1105 AZ

Amsterdam UMC, Locatie AMC, Amsterdam

9713 GZ

Universitair Medisch Centrum Groningen (UMCG), Groningen

6525 GA

Radboudumc, Nijmegen

3015 CC

Erasmus Medisch Centrum, Rotterdam

3508 GA

UMC Utrecht, Utrecht

01220

Baskent University Adana Application and Research Center, Adana

06490

Baskent University Ankara Hospital, Ankara

CF14 2TL

Velindre Cancer Centre, Cardiff

G12 OYN

Beatson West of Scotland Cancer Centre, Glasgow

SM2 5PT

Royal Marsden Hospital- Sutton, Sutton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genmab

INDUSTRY

collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

Belgian Gynaecological Oncology Group

OTHER

collaborator

GOG Foundation

NETWORK

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Seagen, a wholly owned subsidiary of Pfizer

INDUSTRY