458
Participants
Start Date
March 2, 2019
Primary Completion Date
February 28, 2023
Study Completion Date
February 28, 2023
Tenecteplase
The investigational medicinal product (IMP) for this study is tenecteplase. The recommended total dose for this study is weight-based with 0.25 mg of tenecteplase per kg, not exceeding a maximum dose of 25 mg. A single bolus dose should be administered over 5 seconds based on patient weight.
Placebo
Placebo is being used as the comparator since a thrombolytic is only FDA-approved in the United States for use out to 3 hours, and the standard of care guidelines support use out to 4.5 hours.
Columbia University Medical Center, New York
Buffalo General Medical Center, Buffalo
UPMC East Hospital, Monroeville
University of Pittsburgh Medical Center, Pittsburgh
UPMC Mercy, Pittsburgh
UPMC Passavant Hospital, Pittsburgh
Penn Presbyterian Medical Center, Philadelphia
Uni of Pennsylvania, Philadelphia
Pennsylvania Hospital, Philadelphia
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins, Baltimore
University of Virginia, Charlottesville
Guilford Neurologic Research, Greensboro
Mission Hospitals Inc, Asheville
Baptist Medical Center-South, Jacksonville
University of Florida Health at Shands, Gainesville
Jackson Memorial Hospital, Miami
Saint Thomas Rutherford Hospital, Murfreesboro
Saint Thomas Health, Nashville
Saint Thomas Midtown Hospital, Nashville
Vanderbilt University, Nashville
Chattanooga Center for Neurologic Research, Chattanooga
Baptist Health Lexington, Lexington
Baptist Health Corbin, Corbin
Grant Medical Center, Columbus
Doctors Hospital, Columbus
ProMedica Toledo Hospital, Toledo
Cleveland Clinic, Cleveland
Univ of Cincinnati, Cincinnati
St. Catherine Hospital, East Chicago
Community Hospital, Munster
St. Mary Medical Center, Hobart
Henry Ford Macomb Hospital - Clinton Township, Clinton Township
ProMedica Monroe Regional Hospital, Monroe
Henry Ford Hospital, Detroit
McLaren Flint, Flint
Spectrum Health Hospitals, Grand Rapids
Fairview Ridges Hospital, Burnsville
Fairview Southdale, Edina
U of Minnesota MedCtr Fairview, Minneapolis
Sanford Worthington Medical Center, Worthington
Sanford Neurology Clinic, Sioux Falls
Advocate Lutheran General Hospital, Park Ridge
Advocate Christ Medical Center, Oak Lawn
Northwestern University, Chicago
Washington University, St Louis
Uni of Kansas Medical Center, Kansas City
Ascension St. John, Tulsa
Baylor University Medical Center, Dallas
University of Texas at Houston; Neurology, Houston
University of Texas Health Science Center at San Antonio, San Antonio
Valley Baptist Medical Center-Brownsville, Brownsville
Valley Baptist Medical Center, Harlingen
Ascension Seton Hays, Kyle
Ascension Seton Williamson, Round Rock
Dell Seton Medical center at the University of Texas, Austin
Seton Medical Center Austin, Austin
Banner Desert Medical Center, Mesa
Kaiser Permanente Los Angeles, Los Angeles
University of Southern California Medical Center, Los Angeles
Cedars-Sinai Medical Center, Los Angeles
Cedars-Sinai Marina Del Rey Hospital, Marina del Rey
Torrance Memorial Medical Center, Torrance
Kaiser Permanente South Bay Medical Center, Harbor City
Adventist Health Glendale, Glendale
Kaiser Permanente - Ontario, Ontario
UCSD Medical Center - La Jolla, La Jolla
UCSD - Hillcrest; Hillcrest Medical Center, San Diego
Kaiser Permanente - Fontana, Fontana
Kaiser Permanente - Anaheim (E. La Palma), Anaheim
Mills-Peninsula Medical Center, Burlingame
CPMC - Van Ness Campus, San Francisco
CPMC - Davies Campus, San Francisco
Stanford University Medical Center, Palo Alto
John Muir Health, Concord Medical Center, Concord
John Muir Medical Center-Walnut Creek, Walnut Creek
Sutter Davis Hospital, Davis
Sutter Roseville Medical Center, Roseville
Sutter Medical Group, Neurology, Sacramento
The Queen's Medical Center, Honolulu
Providence Portland Medical Center, Portland
Adventist Health Portland, Portland
Providence Saint Vincent's Medical Center, Portland
Oregon Health and Science University, Portland
University of Alabama at Birmingham, Birmingham
Hartford Hospital, Hartford
Baptist Medical Center - Jacksonville, Jacksonville
Massachusetts General Hospital, Boston
Univ of Michigan Medical Ctr, Ann Arbor
JFK Neuroscience Institute, Edison
Atlantic Health System - Overlook Medical Center, Summit
Capital Health Regional Medical Center, Trenton
Riverside Methodist Hospital; Cancer Services, Columbus
Rhode Island Hospital, Providence
Uni of Alberta, Edmonton
Hamilton General Hospital; Pharmacy, Hamilton
Montreal Neurological Inst; Clinical Research Unit, Montreal
Lead Sponsor
Genentech, Inc.
INDUSTRY