Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) for Advanced Melanoma in Anti-Programmed Death-1/Programmed Death-Ligand 1 (PD-1/L1)-Exposed Participants (MK-7902-004/E7080-G000-225/LEAP-004)

PHASE2CompletedINTERVENTIONAL
Enrollment

103

Participants

Timeline

Start Date

January 30, 2019

Primary Completion Date

October 11, 2023

Study Completion Date

October 11, 2023

Conditions
Advanced Melanoma
Interventions
DRUG

lenvatinib

Administered orally once a day during each 21-day cycle.

BIOLOGICAL

pembrolizumab

Administered as an IV infusion on Day 1 Q3W.

Trial Locations (23)

2065

Melanoma Institute Australia ( Site 0152), Wollstonecraft

2480

Lismore Base Hospital ( Site 0153), Lismore

3128

Box Hill Hospital ( Site 0157), Box Hill

4102

Princess Alexandra Hospital ( Site 0154), Woolloongabba

6150

Fiona Stanley Hospital ( Site 0156), Perth

28007

Hospital General Universitario Gregorio Maranon ( Site 0003), Madrid

41009

Hospital Universitario Virgen de la Macarena ( Site 0004), Seville

46014

Hospital General Universitario de Valencia ( Site 0002), Valencia

60068

Advocate Medical Group-Park Ridge ( Site 0313), Park Ridge

68510

Southeast Nebraska Cancer Center ( Site 0316), Lincoln

75246

Texas Oncology-Baylor Charles A. Sammons Cancer Center ( Site 0317), Dallas

85224

Ironwood Cancer & Research Centers ( Site 0312), Chandler

90404

John Wayne Cancer Institute ( Site 0301), Santa Monica

22031-4867

Inova Schar Cancer Institute ( Site 0314), Fairfax

M4N 3M5

Sunnybrook Research Institute ( Site 0654), Toronto

M5G 2M9

Princess Margaret Cancer Centre ( Site 0655), Toronto

H2X 3E4

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0652), Montreal

H4A 3J1

McGill University Health Centre ( Site 0651), Montreal

08036

Hospital Clinic i Provincial Barcelona ( Site 0001), Barcelona

413 45

Sahlgrenska Universitetssjukhuset ( Site 0052), Gothenburg

221 85

Skanes Universitetssjukhus ( Site 0053), Lund

171 64

Karolinska Universitetssjukhuset ( Site 0051), Solna

901 85

Norrlands Universitetssjukhus ( Site 0056), Umeå

All Listed Sponsors
collaborator

Eisai Inc.

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03776136 - Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) for Advanced Melanoma in Anti-Programmed Death-1/Programmed Death-Ligand 1 (PD-1/L1)-Exposed Participants (MK-7902-004/E7080-G000-225/LEAP-004) | Biotech Hunter | Biotech Hunter