Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

475

Participants

Timeline

Start Date

June 3, 2019

Primary Completion Date

June 1, 2027

Study Completion Date

June 1, 2027

Conditions
Bladder Urothelial CarcinomaMuscle Invasive Bladder CarcinomaStage II Bladder Cancer AJCC v8Stage IIIA Bladder Cancer AJCC v8
Interventions
DRUG

Atezolizumab

Given IV

PROCEDURE

Biopsy of Bladder

Undergo a bladder biopsy

DRUG

Cisplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT or MRI

PROCEDURE

Cystoscopy

Undergo a cystoscopy

DRUG

Fluorouracil

Given IV

DRUG

Gemcitabine

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo CT or MRI

DRUG

Mitomycin

Given IV

OTHER

Quality-of-Life Assessment

Ancillary studies

RADIATION

Radiation Therapy

Undergo 3DCRT or IMRT

OTHER

Survey Administration

Ancillary studies

PROCEDURE

Transurethral Resection of Bladder Tumor

Undergo a TURBT

Trial Locations (366)

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

10591

Phelps Memorial Hospital Center, Sleepy Hollow

10604

Memorial Sloan Kettering Westchester, Harrison

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

11794

Stony Brook University Medical Center, Stony Brook

11795

Good Samaritan University Hospital, West Islip

13210

State University of New York Upstate Medical University, Syracuse

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15108

UPMC Hillman Cancer Center in Coraopolis, Moon Township

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15146

UPMC Cancer Center - Monroeville, Monroeville

15213

UPMC-Magee Womens Hospital, Pittsburgh

15215

UPMC-Saint Margaret, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

UPMC-Shadyside Hospital, Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15243

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15301

UPMC Washington Hospital Radiation Oncology, Washington

15401

UPMC Uniontown Hospital Radiation Oncology, Uniontown

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15642

Arnold Palmer Cancer Center Medical Oncology Norwin, N. Huntingdon

15901

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16105

UPMC Hillman Cancer Center - New Castle, New Castle

16121

UPMC Cancer Center at UPMC Horizon, Farrell

16346

UPMC Cancer Center at UPMC Northwest, Seneca

16505

UPMC Hillman Cancer Center Erie, Erie

16601

UPMC Altoona, Altoona

17015

Carlisle Regional Cancer Center, Carlisle

17050

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17408

UPMC Memorial, York

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19967

Beebe South Coastal Health Campus, Millville

19971

Beebe Health Campus, Rehoboth Beach

20016

Sibley Memorial Hospital, Washington D.C.

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22939

Augusta Health Center for Cancer and Blood Disorders, Fishersville

26506

West Virginia University Healthcare, Morgantown

28349

ECU Health Oncology Kenansville, Kenansville

28501

ECU Health Oncology Kinston, Kinston

28574

ECU Health Oncology Richlands, Richlands

28791

Margaret R Pardee Memorial Hospital, Hendersonville

29303

Spartanburg Medical Center, Spartanburg

29425

Medical University of South Carolina, Charleston

29577

Carolina Regional Cancer Center, Myrtle Beach

29605

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29650

Prisma Health Cancer Institute - Greer, Greer

29651

Gibbs Cancer Center-Pelham, Greer

30265

CTCA at Southeastern Regional Medical Center, Newnan

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

32610

University of Florida Health Science Center - Gainesville, Gainesville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33140

Mount Sinai Medical Center, Miami Beach

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

Mount Sinai Comprehensive Cancer Center at Aventura, Aventura

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33612

Moffitt Cancer Center, Tampa

34232

Florida Cancer Specialists - Sarasota, Sarasota

34236

Florida Cancer Specialists - Sarasota Downtown, Sarasota

34239

First Physicians Group - Urology Robotic and Minimally Invasive Surgery, Sarasota

Sarasota Memorial Hospital, Sarasota

34243

Sarasota Memorial Health Care Center at University Parkway, Sarasota

34275

Sarasota Memorial Hospital-Venice, N. Venice

37232

Vanderbilt University/Ingram Cancer Center, Nashville

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

40207

Baptist Health Louisville, Louisville

40503

Baptist Health Lexington, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

44109

MetroHealth Medical Center, Cleveland

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45409

Greater Dayton Cancer Center, Kettering

45415

Dayton Physician LLC - Englewood, Dayton

45429

Kettering Medical Center, Kettering

46219

Community Cancer Center East, Indianapolis

46227

Community Cancer Center South, Indianapolis

46256

Community Cancer Center North, Indianapolis

47374

Reid Health, Richmond

48044

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48071

Michigan Healthcare Professionals Madison Heights, Madison Heights

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48093

Henry Ford Health Warren Hospital, Warren

48098

Michigan Healthcare Professionals Troy, Troy

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

Trinity Health Medical Center - Brighton, Brighton

48116

University of Michigan - Brighton Center for Specialty Care, Brighton

48118

Chelsea Hospital, Chelsea

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Trinity Health Medical Center - Canton, Canton

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48236

Henry Ford Health Saint John Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

Michigan Healthcare Professionals Farmington, Farmington Hills

Weisberg Cancer Treatment Center, Farmington Hills

48336

Corewell Health Farmington Hills Hospital, Farmington Hills

48341

Michigan Healthcare Professionals Pontiac, Pontiac

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48346

Michigan Healthcare Professionals Clarkston, Clarkston

48601

MyMichigan Medical Center Saginaw, Saginaw

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49519

University of Michigan Health - West, Wyoming

49684

Munson Medical Center, Traverse City

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50801

Greater Regional Medical Center, Creston

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53405

Ascension All Saints Hospital, Racine

53406

Aurora Cancer Care-Racine, Racine

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

Bellin Memorial Hospital, Green Bay

54311

Aurora BayCare Medical Center, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54449

Marshfield Medical Center-Marshfield, Marshfield

54451

Aspirus Medford Hospital, Medford

54476

Marshfield Medical Center - Weston, Weston

54481

Aspirus Cancer Care - Stevens Point, Stevens Point

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Mayo Clinic Health System-Franciscan Healthcare, La Crosse

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

Mayo Clinic Health System-Eau Claire Clinic, Eau Claire

54806

Northwest Wisconsin Cancer Center, Ashland

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Ascension Mercy Hospital, Oshkosh

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54915

Ascension Saint Elizabeth Hospital, Appleton

55101

Regions Hospital, Saint Paul

55362

Monticello Cancer Center, Monticello

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55805

Miller-Dwan Hospital, Duluth

55905

Mayo Clinic in Rochester, Rochester

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Joe Lueken Cancer Center, Bemidji

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59715

Bozeman Health Deaconess Hospital, Bozeman

60010

Advocate Good Shepherd Hospital, Barrington

60014

AMG Crystal Lake - Oncology, Crystal Lake

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60048

AMG Libertyville - Oncology, Libertyville

Condell Memorial Hospital, Libertyville

60068

Advocate Lutheran General Hospital, Park Ridge

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60123

Advocate Sherman Hospital, Elgin

60126

Elmhurst Memorial Hospital, Elmhurst

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60141

Edward Hines Jr VA Hospital, Hines

60153

Loyola University Medical Center, Maywood

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60429

Advocate South Suburban Hospital, Hazel Crest

60515

Advocate Good Samaritan Hospital, Downers Grove

60540

Edward Hospital/Cancer Center, Naperville

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

Rush MD Anderson Cancer Center, Chicago

60657

Advocate Illinois Masonic Medical Center, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Decatur Memorial Hospital, Decatur

62702

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

63080

Missouri Baptist Sullivan Hospital, Sullivan

63110

Washington University School of Medicine, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64154

University of Kansas Cancer Center - North, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

65807

CoxHealth South Hospital, Springfield

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

67214

Ascension Via Christi Hospitals Wichita, Wichita

68114

Nebraska Methodist Hospital, Omaha

68118

Nebraska Medicine-Village Pointe, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68198

University of Nebraska Medical Center, Omaha

68847

CHI Health Good Samaritan, Kearney

70006

East Jefferson General Hospital, Metairie

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70112

University Medical Center New Orleans, New Orleans

70809

Louisiana Hematology Oncology Associates LLC, Baton Rouge

Mary Bird Perkins Cancer Center, Baton Rouge

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

Michael E DeBakey VA Medical Center, Houston

80045

UCHealth University of Colorado Hospital, Aurora

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80524

Poudre Valley Hospital, Fort Collins

80528

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

Medical Center of the Rockies, Loveland

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

UCHealth Greeley Hospital, Greeley

80909

UCHealth Memorial Hospital Central, Colorado Springs

80920

Memorial Hospital North, Colorado Springs

81632

Shaw Cancer Center, Edwards

85054

Mayo Clinic Hospital in Arizona, Phoenix

85259

Mayo Clinic in Arizona, Scottsdale

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

89102

OptumCare Cancer Care at Charleston, Las Vegas

89106

Radiation Oncology Centers of Nevada Central, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89128

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

89144

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

OptumCare Cancer Care at Fort Apache, Las Vegas

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

89502

Renown Regional Medical Center, Reno

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

90048

Cedars Sinai Medical Center, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95355

Memorial Medical Center, Modesto

95602

Sutter Auburn Faith Hospital, Auburn

95603

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95608

Mercy Cancer Center - Carmichael, Carmichael

Mercy San Juan Medical Center, Carmichael

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95695

Woodland Memorial Hospital, Woodland

95758

Mercy Cancer Center - Elk Grove, Elk Grove

95765

Mercy Cancer Center - Rocklin, Rocklin

95816

Mercy Cancer Center - Sacramento, Sacramento

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95901

Fremont - Rideout Cancer Center, Marysville

96701

Hawaii Cancer Care - Westridge, ‘Aiea

Pali Momi Medical Center, ‘Aiea

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

96817

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

97239

Oregon Health and Science University, Portland

98001

MultiCare Auburn Medical Center, Auburn

98034

FHCC at EvergreenHealth, Kirkland

98055

Valley Medical Center, Renton

98109

Fred Hutchinson Cancer Center, Seattle

98195

University of Washington Medical Center - Montlake, Seattle

98335

MultiCare Gig Harbor Medical Park, Gig Harbor

98372

MultiCare Good Samaritan Hospital, Puyallup

98383

Saint Michael Cancer Center, Silverdale

98405

MultiCare Tacoma General Hospital, Tacoma

06830

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

Smilow Cancer Hospital Care Center - Guilford, Guilford

06102

Hartford Hospital, Hartford

06451

Midstate Medical Center, Meriden

06050

The Hospital of Central Connecticut, New Britain

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06385

Smilow Cancer Hospital Care Center - Waterford, Waterford

60453-2699

Advocate Christ Medical Center, Oak Lawn

04530

MaineHealth Coastal Cancer Treatment Center, Bath

04915

MaineHealth Waldo Hospital, Belfast

04005

MaineHealth Maine Medical Center - Biddeford, Biddeford

04268

MaineHealth Stephens Hospital, Norway

04102

MaineHealth Maine Medical Center - Portland, Portland

04856

Penobscot Bay Medical Center, Rockport

04073

MaineHealth Cancer Care and IV Therapy - Sanford, Sanford

MaineHealth Cancer Care Center of York County, Sanford

04074

MaineHealth Maine Medical Center- Scarborough, Scarborough

04106

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

01854

Lowell General Hospital, Lowell

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

08103

Cooper Hospital University Medical Center, Camden

07601

Hackensack University Medical Center, Hackensack

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

08043

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

77555-0565

University of Texas Medical Branch, Galveston

05819

Dartmouth Cancer Center - North, Saint Johnsbury

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT03775265 - Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer | Biotech Hunter | Biotech Hunter