714
Participants
Start Date
December 17, 2018
Primary Completion Date
July 25, 2024
Study Completion Date
September 10, 2026
Pembrolizumab 200 mg
200 mg administered IV infusion on Day 1 of each 21-day cycle
Radiotherapy 60 Gray
Low risk participants administered 2 Gray in 30 fractions. Administered using intensity modulated radiation therapy.
Radiotherapy 66 Gray
High risk participants administered 2 Gray in 33 fractions. Administered using intensity modulated radiation therapy.
Radiotherapy 70 Gray
Participants with gross residual disease administered 2 Gray in 35 fractions. Administered using intensity modulated radiation therapy.
Cisplatin 100 mg/m^2
100 mg/m\^2 administered by IV infusion on Day 1 of each 21-day cycle
National Cheng Kung University Hospital ( Site 1302), Tainan City
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 1303), Kaohsiung City
IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas ( Site 0016), Buenos Aires
Eszak-Pesti Centrumkorhaz-Honvedkorhaz ( Site 0453), Budapest
Medizinische Universität Wien ( Site 1903), Vienna
Orszagos Onkologiai Intezet ( Site 0454), Budapest
Hopitaux Universitaires de Geneve HUG ( Site 1920), Geneva
Fundacion Estudios Clinicos-Oncology ( Site 0017), Rosario
The Crown Princess Mary Cancer Centre - Westmead Hospital ( Site 0051), Westmead
Ordensklinikum Linz Gmbh - Barmherzige Schwestern ( Site 1901), Linz
Royal Brisbane and Women s Hospital ( Site 0050), Herston
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 0450), Szolnok
Landeskrankenhaus Salzburg - Universitatklinikum der PMU ( Site 1900), Salzburg
Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 1921), Bellinzona
Hopital de Jolimont ( Site 0103), Haine-Saint-Paul
Pecsi Tudomanyegyetem Onkoterapias Intezet ( Site 0452), Pécs
Landeskrankenhaus - Universitatsklinikum Graz ( Site 1902), Graz
Universitaetsspital Zurich ( Site 1923), Zuerich
UZ Gent ( Site 0101), Ghent
AZ Nikolaas ( Site 0104), Sint-Niklaas
National Taiwan University Hospital ( Site 1300), Taipei
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 2014), New York
Memorial Sloan Kettering Cancer Center ( Site 1857), New York
Weill Cornell Medical College ( Site 2050), New York
Northwell Health Cancer Institute ( Site 2030), New York
National Cancer Center ( Site 0702), Goyang-si
Montefiore Einstein Center ( Site 2028), The Bronx
Memorial Sloan-Kettering Cancer Center at West Harrison ( Site 2041), Harrison
Monter Cancer Center ( Site 2060), Lake Success
Memorial Sloan Kettering Cancer Center - Nassau ( Site 2040), Uniondale
Memorial Sloan-Kettering Cancer Center at Commack ( Site 2038), Commack
Stony Brook University ( Site 2063), Stony Brook
Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 0414), Berlin
Hopital de la Timone ( Site 0356), Marseille
Seoul National University Bundang Hospital ( Site 0703), Seongnam-si
Erie County Medical Center ( Site 2047), Buffalo
Allegheny General Hospital ( Site 1833), Pittsburgh
Hospital Clinico Universitario de Santiago ( Site 1207), Santiago de Compostela
The Catholic University of Korea St. Vincent s Hospital ( Site 0704), Gyeonggi-do
St. Luke's University Health Network ( Site 1801), Bethlehem
Sidney Kimmel Cancer Center - Jefferson Health ( Site 2059), Philadelphia
MedStar Washington Hospital Center ( Site 2062), Washington D.C.
George Washington University Medical Faculty Associates ( Site 2035), Washington D.C.
Universitaetsklinikum Hamburg Eppendorf ( Site 0407), Hamburg
University of Maryland ( Site 2031), Baltimore
Inova Schar Cancer Institute ( Site 2026), Fairfax
UVA Health System - Emily Couric Cancer Center ( Site 1826), Charlottesville
Universitätsklinikum Schleswig-Holstein ( Site 0411), Lübeck
PP PPC Acinus Medical and Diagnostic Centre ( Site 1704), Kropyvnytskyi
Ukrainian Center of Tomotherapy ( Site 1708), Kropyvnitskiy
Wake Forest Compenhensive Cancer Center ( Site 2029), Winston-Salem
Hospital Universitario La Paz ( Site 1201), Madrid
Levine Cancer Institute ( Site 2003), Charlotte
Institut Claudius Regaud IUCT Oncopole ( Site 0355), Toulouse
University of Florida ( Site 1832), Gainesville
AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlando ( Site 2054), Orlando
Orlando Health Cancer Institute ( Site 2061), Orlando
University of Miami, Sylvester Comprehensive Cancer Center ( Site 2008), Miami
Klinikum Kassel GmbH ( Site 0404), Kassel
Henry Joyce Cancer Clinic ( Site 1827), Nashville
University of Kentucky Chandler Medical Center-Medical Oncology ( Site 2069), Lexington
Taichung Veterans General Hospital ( Site 1301), Taichung
Hospital Universitario Virgen del Rocio ( Site 1206), Seville
The Ohio State University ( Site 2012), Columbus
Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 0901), Gliwice
University Hospitals ( Site 2032), Cleveland
Karmanos Cancer Institute ( Site 1870), Detroit
Henry Ford Health System ( Site 1803), Detroit
Dnipropetrovsk Regional Hospital n.a. I.I. Mechnikov ( Site 1709), Dnipropetrovsk
Clinical oncology dispensary of Dnipro ( Site 1706), Dnipro
Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council ( Site 1705), Dnipro
Universitaetsklinikum Koeln ( Site 0413), Cologne
Southdale Cancer Care, University of Minnesota Medical Center- Edina ( Site 2016), Edina
Sanford Cancer Center Oncology Clinic ( Site 1859), Sioux Falls
Avera Cancer Institute- Research ( Site 2070), Sioux Falls
Sanford Health Roger Maris Cancer Center ( Site 2034), Fargo
Chonnam National University Hwasun Hospital ( Site 0705), Hwasun Gun
St. Vincent Healthcare Frontier Cancer Center ( Site 1818), Billings
Loyola University Medical Center [Maywood, IL] ( Site 1817), Maywood
NorthShore University HealthSystem ( Site 1812), Evanston
Universitaetsklinikum Frankfurt ( Site 0403), Frankfurt am Main
Rush University Medical Center ( Site 1823), Chicago
Washington University School of Medicine ( Site 1800), St Louis
University of Missouri Hospital-Otolaryngology - Head and Neck Surgery ( Site 2058), Columbia
Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center ( Site 1897), Springfield
University of Kansas Cancer Center ( Site 2004), Westwood
Ochsner Cancer Institute ( Site 2045), New Orleans
Universitaetsklinikum Tuebingen - Medizinische Klinik ( Site 0401), Tübingen
Hopital Europeen Georges Pompidou ( Site 0358), Paris
Institut Curie ( Site 0350), Paris
UT Southwestern Medical Center ( Site 1841), Dallas
USA Clinical Trials ( Site 2068), San Antonio
University of Colorado Cancer Center ( Site 1838), Aurora
Klinikum rechts der Isar der Technischen Universitaet ( Site 0409), Munich
Klinikum rechts der Isar der Technischen Universität München-HNO Klinik ( Site 0405), München
Saint Alphonsus Regional Medical Center ( Site 2021), Boise
Beacon Cancer Care ( Site 2052), Post Falls
Institut Sainte Catherine ( Site 0352), Avignon
Universitaetsklinikum Ulm ( Site 0402), Ulm
University of Southern California Norris Comprehensive Cancer Center ( Site 1850), Los Angeles
Universitaetsklinikum Erlangen-Strahlenklinik ( Site 0412), Erlangen
Hoag Memoriall Hospital Presbyterian ( Site 2056), Newport Beach
Institut Gustave Roussy ( Site 0353), Villejuif
St. Joseph Heritage Healthcare ( Site 1806), Santa Rosa
UC Davis Health System ( Site 1864), Sacramento
Providence Portland Medical Center ( Site 1843), Portland
Kaiser Permanente Center for Health Research-Kaiser Permanente Medical Center ( Site 2022), Portland
Oregon Health Science University ( Site 1871), Portland
Seattle Cancer Care Alliance/Univ of Washington Medical Center ( Site 1865), Seattle
Centro de Investigacion Clinica del Country ( Site 0304), Bogotá
N.N. Blokhin NMRCO ( Site 1005), Moscow
Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1001), Yaroslavl
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1000), Kazan'
Oncologos del Occidente S.A. ( Site 0310), Pereira
Centro Medico Imbanaco de Cali S.A ( Site 0300), Santiago de Cali
Rambam Health Care Campus-Oncology Division ( Site 0550), Haifa
Rabin Medical Center ( Site 0552), Petah Tikva
Chaim Sheba Medical Center. ( Site 0553), Ramat Gan
Sourasky Medical Center ( Site 0551), Tel Aviv
Fundacion Arturo Lopez Perez FALP ( Site 0251), Santiago
Hadassah Medical Center. Ein Kerem ( Site 0554), Jerusalem
Moores Cancer Center ( Site 1885), La Jolla
Dana Farber Cancer Center ( Site 1873), Boston
University of Massachusetts Memorial Medical Center ( Site 1875), Worcester
Memorial Sloan Kettering Cancer Center Basking Ridge ( Site 2036), Basking Ridge
Memorial Sloan Kettering Cancer Center- Monmouth ( Site 2039), Middletown
MSKCC-Bergen ( Site 2037), Montvale
Rutgers Cancer Institute of New Jersey ( Site 2071), New Brunswick
Rutgers New Jersey Medical School-department of Hematology oncology ( Site 2053), Newark
The University of New Mexico Comprehensive Cancer Center ( Site 1882), Albuquerque
University of Utah, Huntsman Cancer Institute ( Site 1855), Salt Lake City
University of Vermont Medical Center ( Site 2009), Burlington
Hospital Universitario Austral ( Site 0009), Pilar
Centro de Educación Médica e Investigaciones Clínicas (CEMIC)-Medical Oncology ( Site 0019), Buenos Aires
Hospital Britanico de Buenos Aires ( Site 0012), Ciudad de Buenos Aires
Sanatorio Britanico ( Site 0013), Rosario
Instituto de Oncologia de Rosario ( Site 0002), Rosario
Hospital Provincial del Centenario ( Site 0008), Rosario
Hospital Aleman Buenos Aires Argentina ( Site 0004), Buenos Aires
Instituto de Oncología Angel Roffo ( Site 0003), Buenos Aires
CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica ( Site 0010), San Juan
Centro Regional Integrado de Oncologia ( Site 0160), Fortaleza
Hospital Santa Izabel - Santa Casa de Misericordia da Bahia ( Site 0155), Salvador
Hospital Marcio Cunha-Unidade de Pesquisa Clínica ( Site 0177), Ipatinga
Liga Norte Riograndense Contra o Cancer ( Site 0171), Natal
Hospital Nossa Senhora da Conceicao ( Site 0165), Porto Alegre
Hospital de Base de Sao Jose de Rio Preto ( Site 0153), São José do Rio Preto
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0169), Rio de Janeiro
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0167), São Paulo
BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0175), São Paulo
Cross Cancer Institute ( Site 0201), Edmonton
Sunnybrook Research Institute ( Site 0211), Toronto
Princess Margaret Cancer Centre ( Site 0202), Toronto
McGill University Health Centre ( Site 0210), Montreal
CIUSSS de l'Estrie-CHUS ( Site 0209), Sherbrooke
Clinica de la Costa S.A.S. ( Site 0307), Barranquilla
Centre Antoine Lacassagne ( Site 0351), Nice
SRH Wald-Klinikum Gera GmbH ( Site 0406), Gera
St. James s Hospital ( Site 0500), Dublin
Aichi Cancer Center Hospital ( Site 0658), Nagoya
National Cancer Center Hospital East ( Site 0661), Kashiwa
Hyogo Cancer Center ( Site 0656), Akashi
Kagawa University Hospital ( Site 0651), Kita-gun
Yokohama City University Hospital ( Site 0657), Yokohama
Chiba Cancer Center ( Site 0652), Chiba
National Hospital Organization Kyushu Cancer Center ( Site 0660), Fukuoka
Hiroshima University Hospital ( Site 0655), Hiroshima
National Cancer Center Hospital ( Site 0650), Tokyo
Tokyo Medical and Dental University Hospital ( Site 0654), Tokyo
Tokyo Medical University Hospital ( Site 0659), Tokyo
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 0905), Krakow
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warsaw
Szpitale Pomorskie Sp. z o.o. ( Site 0935), Gdynia
Wojewodzki Szpital Specjalistyczny im. M. Kopernika w Lodzi ( Site 0920), Lodz
Hospital de Braga ( Site 0951), Braga
CHLN Hospital Santa Maria ( Site 0952), Lisbon
Hospital CUF Descobertas ( Site 0953), Lisbon
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 0950), Porto
Severance Hospital, Yonsei University Health System ( Site 0701), Seoul
Hospital Germans Trias i Pujol. ICO de Badalona ( Site 1204), Badalona
ICO L Hospitalet ( Site 1208), L'Hospitalet de Llobregat
Hospital Vall D Hebron ( Site 1200), Barcelona
LISOD. Hospital ( Site 1707), Pliuty
Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 1703), Kapitanivka Village
National Cancer Institute of the MoH of Ukraine ( Site 1702), Kyiv
Kyiv City Clinical Oncology Centre ( Site 1701), Kyiv
Addenbrooke's Hospital ( Site 1610), Cambridge
Castle Hill Hospital ( Site 1601), Cottingham-Hull
Guy s & St Thomas NHS Foundation Trust ( Site 1604), London
Royal Marsden Hospital - Fulham Road London ( Site 1609), London
Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 1603), London
Weston Park Hospital ( Site 1607), Sheffield
Merck Sharp & Dohme LLC
INDUSTRY