A Study to Evaluate SHR-1210 in Combination With Apatinib as First-Line Therapy in Patients With Advanced HCC

PHASE3CompletedINTERVENTIONAL
Enrollment

543

Participants

Timeline

Start Date

June 10, 2019

Primary Completion Date

February 8, 2022

Study Completion Date

June 14, 2023

Conditions
Locally Advanced or Metastatic and Unresectable HCC
Interventions
DRUG

SHR-1210

Subjects receive SHR-1210 intravenously, Dosage form: lyophilised powder, Strength: 200 mg /vial

DRUG

Apatinib

Subjects receive Apatinib orally, Dosage form: tablet, Strength: 250 mg/tablet

DRUG

Sorafenib

Subjects receive Sorafenib orally, Dosage form: tablet, Strength: 0.2 g/tablet

Trial Locations (121)

100

National Taiwan University Hospital, Taipei

333

Chang Gung Memorial Hospital, Linkou, Taoyuan District

613

Chang Gung Memorial Hospital, Chiayi, Chiayi City

704

National Cheng Kung University Hospital, Tainan City

833

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

1070

Cliniques Universitaires de Bruxelles Hopital Erasme, Brussels

1200

Cliniques Universitaires Saint-Luc, Brussels

2650

UZA, Edegem

8500

AZ Groeninge, Kortrijk

9000

AZ Maria Middelares, Ghent

10065

Cornell University Weill Cornell Medical College, New York

11217

Taipei Veterans General Hospital, Taipei

13353

Charite Universitaetsmedizin Berlin - Campus Virchow-Klinikum Berlin, Berlin

13620

Seoul National University Bundang Hospital Gyeonggi-do, Seongnam-si

14004

Hospital Universitario Reina Sofia, Córdoba

16247

The Catholic University of Korea, St. Vincent's Hospital, Suwon

16499

Ajou University Hospital, Suwon

20122

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Milan

21201

University of Maryland, Baltimore

25123

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili), Brescia

28034

Hospital Universitario Ramon y Cajal, Madrid

28040

Hospital Universitario Clinico San Carlos, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28050

Hospital Universitario HM Madrid Sanchinarro, Madrid

30510

Pratia MCM Krakow, Krakow

34098

Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul

34147

Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul

37134

Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma), Verona

40022

CNCE of SRC Sumy Reg Clinical Oncology Dispensary, SSU, Chair of Oncology and Radiology, Sumy

40138

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS, Bologna

43018

Communal Enterprise Volyn Regional Medical Center of Oncology of Volyn Regional Council, Lutsk

44101

Centrum Onkologii-Instytut im.M.Sklodowskiej Curie, Gliwice

44280

Inonu Uni. Med. Fac., Malatya

46026

Hospital Universitari i Politecnic La Fe, Valencia

49102

"CNECity Clin Hosp#4of Dnipro City Council Dept of Chemotherapy SI Dnipropetrovsk MA of MOHU", Dnipro

50134

Azienda Ospedaliera Universitaria Careggi, Florence

51162

NZOZ Centrum Badan Klinicznych, Wroclaw

60693

Przychodnia Med-Polonia Sp. z o.o., Poznan

61070

Communal Non-profit Enterprise Regional Center of Oncology, Kharkiv

61166

CI of Healthcare Regional Clinical Specialized Dispensary of the Radiation Protection, Kharkiv

61866

Wielkopolskie Centrum Onkologii, Poznan

65025

Communal Institution Odesa Regional Clinical Hospital, Odesa

69032

Zaporizhzhya City Clinical Hospital #3, Zaporizhzhia

76104

The Center for Cancer and Blood Disorders, Fort Worth

77030

MD Anderson Cancer Center, Houston

77380

Renovatio Clinical, The Woodlands

80147

A.S.L. Napoli 1 Centro Ospedale del Mare, Ponticelli

81338

Centrum Medyczne Pratia Gdynia, Gdynia

82445

E-DA Cancer Hospital, Kaohsiung City

90211

Beverly Hills Cancer Center, Beverly Hills

92037

University of California San Diego (UCSD)-Moores Cancer Center, La Jolla

92868

University of California - Irvine, Orange

100020

Chinese Academy of Medical Sciences Cancer Hospital, Beijing

100089

Beijing cancer Hospital, Beijing

102206

Peking University International Hospital, Beijing

110006

The Sixth People's Hospital of Shengyang, Shengyang

110042

Liaoning Cancer Hospital, Shenyang

121309

"VitaMed LLC", Moscow

130000

Jilin Cancer Hospital, Changchun

The First Hospital of Jilin University, Changchun

143423

"SBIH of Moscow city Moscow city oncology hospital №62 of Moscow Healthcare departement", Moscow

150000

Harbin Medical University Cancer Hospital, Harbin

164045

"SBIH of Arkhangelsk region Arkhangelsk Clinical Oncological Dispensary", Arkhangelsk

197022

Pavlov First Saint Petersburg State Medical University, Saint Petersburg

"SPb SBIH City Clinical Oncological Dispensary", Saint Petersburg

197758

"FBI Scientific Research Institute of Oncology n. a. N. N. Petrov", Saint Petersburg

200032

Fudan University Shanghai Cancer Center, Shanghai

Zhongshan Hospital, Fudan University, Shanghai

200043

Shanghai Changhai Hospital, Shanghai

210002

Eastern Theater General Hospital, Qinhuai District Medical Area, Nanjing

230000

Anhui Provincal Cancer Hospital, Hefei

Anhui Provincal Hospital, Hefei

230009

The First Affiliated Hospital Of Anhui Medical University, Hefei

230601

The Second Affiliated Hospital Of Anhui Medical University, Hefei

250000

Shandong Cancer Hospital Affiliated to Shandong University, Jinan

305035

"RBIH Kursk regional clinical oncology dispensary of Kursk Region Healthcare Committee", Kursk

310016

Sir Run Run Shaw Hospital, Hangzhou

310022

ZheJiang Cancer Hospital, Hangzhou

330006

The First Affiliated Hospital Of Nanchang University, Nanchang

350001

Fujian Medical University Union Hospital, Fuzhou

350040

"SBIH Clinical Oncological Dispensary # 1", Krasnodar

400037

The Second Hospital Affiliated To AMU, Chongqing

400038

The First Hospital Affiliated To AMU, Chongqing

400042

TheThird Affiliated Hospital ,Army Medical University, Chongqing

400060

The Second Affiliated Hospital of ChongQing Medical University, Chongqing

410006

Hunan Cancer Hospital, Changsha

430022

Wuhan Union Hospital,Tongji Medical College,Huazhong University of Science&Technology, Wuhan

430030

Tongji hospital,Tongji Medical College,Huazhong University of Science&Technology, Wuhan

450054

SBIH Republican Clinical Oncological Dispensary of the MoH of Republic Bashkortostan, Ufa

454087

SBHI Chelyabinsk Regional Clinical Center for Oncology and Nuclear Medicine, Chelyabinsk

500006

Changhua Christian Medical Foundation Changhua Christian Hospital, Changhua

510060

Sun Yat-sen University Cancer Center, Guangzhou

510220

Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou

510515

NanFang Hospital of Southern Medical University, Guangzhou

530021

The first affiliated hospital of guangxi medical university, Nanning

602715

Dong-A University Hospital, Busan

610041

West China Hospital of Sichuan University, Chengdu

610054

Sichuan Cancer Hospital&Institute, Chengdu

630099

CJSC Avicenna, Novosibirsk

644013

"BHI of Omsk region Clinical Oncology Dispensary", Omsk

664035

Irkutsk Regional Oncology Dispensary, Irkutsk

Unknown

The 940th Hospital of the joint logistic support force of People's Liberation Army, Lanzhou

The First Affiliated Hospital, Zhejiang University, Hangzhou

Pamela Youde Nethersole Eastern Hospital, Hong Kong

The University of Hong Kong, Hong Kong

Tuen Mun Hospital, Hong Kong

The Chinese University of Hong Kong, Shatin

050011

The Fourth Hospital of Hebei Medical University, Shijiazhuang

09124

Azienda Ospedaliero-Universitaria, Cagliari

00168

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

00635

Centrum Zdrowia MDM, Warsaw

02034

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw

02481

Korea University Anam Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

01229

Baskent University Adana Application and Research Center, Adana

06105

Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital, Ankara

06800

Ankara City Hospital, Ankara

04050

Medical Center of Limited Liability Company Medical Center Concilium Medical, Kyiv

All Listed Sponsors
lead

Jiangsu HengRui Medicine Co., Ltd.

INDUSTRY

NCT03764293 - A Study to Evaluate SHR-1210 in Combination With Apatinib as First-Line Therapy in Patients With Advanced HCC | Biotech Hunter | Biotech Hunter