433
Participants
Start Date
April 10, 2019
Primary Completion Date
August 31, 2026
Study Completion Date
January 31, 2027
Standard of Care
Androgen deprivation with or without docetaxel chemotherapy, Abiraterone, Enzalutamide or any other proven agent) treatment as determined by treating physician (positive control).
Minimally Invasive Ablative Therapy (MIAT)
"MIAT includes High intensity focused ultrasound (HIFU) or Cryotherapy to the prostate.~Metastatic Directed Therapy available for use."
Radical Therapy (Prostatectomy or Radiotherapy)
"Radical therapy includes: Prostatectomy (any surgical approach) or External beam radiotherapy (High dose).~Metastatic Directed Therapy available for use."
Wirral University Teaching Hospital, Wirral University Teaching Hospital NHS Foundation Trust, Birkenhead
Glan Clwyd Hospital, Bodelwyddan
Darent Valley Hospital, Dartford
Buckinghamshire Healthcare NHS Trust, High Wycombe
North Middlesex University Hospital, London
Northwick Park, London North West Healthcare NHS Trust, London
St George's University Hospital, London
University College London Hospital, London
Clatterbridge Cancer Centre, Metropolitan Borough of Wirral
Oxford University Hospital, Oxford
Southend University Hospital, Westcliff-on-Sea
Royal Devon and Exeter NHS Trust, Exeter
West Middlesex University Hospital, Isleworth
Queen Elizabeth Hospital, Kings Lynn, Kings Lynn
Chelsea and Westminster Hospital, London
The Royal Marsden NHS Foundation Trust, Chelsea Research Centre, London
Imperial College Healthcare NHS Trust, London
Freeman Hospital, Newcastle, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle
Southampton General Hospital, University Hospital Southampton NHS Foundation Trust (UHS), Southampton
Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, Sunderland
Croydon University Hospital, Thornton Heath
Wellcome Trust
OTHER
Imperial College London
OTHER