A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants With Manifest Huntington's Disease

PHASE3CompletedINTERVENTIONAL
Enrollment

899

Participants

Timeline

Start Date

January 23, 2019

Primary Completion Date

March 24, 2022

Study Completion Date

March 24, 2022

Conditions
Huntingtons Disease
Interventions
DRUG

RO7234292

Intrathecal injection

DRUG

Placebo

Intrathecal injection

Trial Locations (96)

2100

Rigshospitalet, Hukommelsesklinikken, København Ø

2145

WESTMEAD HOSPITAL; Deparment of Neurology, Westmead

3050

Royal Melbourne Hospital; Department of Neurology, Parkville

3073

Neurozentrum Siloah, Gümligen

3168

Monash Medical Centre, Clayton

4031

Universitätsspital Basel; Neurologie, Basel

5020

Christian-Doppler-Klinik - Universitätsklinikum; Universitätskliniik für Neurologie, Salzburg

6020

Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck; Department fuer Neurologie, Innsbruck

6021

Wellington Hospital; Department of Neurology, Wellington

8011

New Zealand Brain Research Institute, Christchurch

8200

Aarhus Universitetshospital; Neurologisk Afdeling F, Neurogenetisk Afsnit, Aarhus N

10117

Charité - Universitätsmed. Berlin, Klinik für Psychiatrie und Psychotherapie; Abt. Neuropsychiatrie, Berlin

13005

CHU de la Timone - Hopital d Adultes; Service de Neurologie, Marseille

14226

Dent Neurological Institute, Amherst

15213

University of Pittsburgh, Pittsburgh

16132

Irccs A.O.U.San Martino Ist; Dinogmi, Genoa

20007

Georgetown University; Research Division, Psychiatry, Washington D.C.

20133

Fondazione IRCCS Istituto Neurologico Carlo Besta; U.O.C. Genetica Medica-Neurogenetica, Milan

21287

John Hopkins University School of Medicine, Baltimore

23538

Universitätsklinikum Schleswig-Holstein / Campus Lübeck; Zentrum für Seltene Erkrankungen, Lübeck

28034

Hospital Ramon y Cajal; Servicio de Neurologia, Madrid

28040

Fundacion Jimenez Diaz; Servicio de Neurología, Madrid

31059

CHU toulouse - Hôpital Purpan; Departement de Neurologie, Toulouse

33613

University of South Florida, Tampa

34295

Hopital Gui de Chauliac; Neurologie, Montpellier

35294

Uab Medicine, Birmingham

37212

Vanderbilt University Medical Center, Nashville

40139

IRCCS Istituto delle Scienze Neurologiche; UOC Clinica Neurologica, Bologna

41009

Hospital Universitario Virgen Macarena; Servicio de Neurologia, Seville

44791

St. Josef-Hospital, Neurologische Klinik der Ruhr-Uni; Huntington-Center NRW, Abt. Neurodegeneration, Bochum

46026

Hospital Universitario la Fe; Servicio de Neurologia, Valencia

48149

George-Huntington- Institut GmbH; Technologiepark Münster, Münster

48903

Hospital de Cruces; Servicio de Neurologia, Barakaldo

49933

CHU Angers, Batiement Larrey 2, Neurologie, Angers

52074

Uniklinik RWTH Aachen; Klinik für Neurologie, Aachen

53127

German Center for Neurodegenerative Diseases (DZNE), Bonn

60611

Northwestern University, Chicago

63110

Washington University School of Medicine, St Louis

71013

IRCCS Casa Sollievo Della Sofferenza; Unità Ricerca e Cura Huntington e Malattie Rare, San Giovanni Rotondo

75651

Hôpital Pitié Salpêtrère; Département de Génétique et Cytogénétique, Paris

77030

The University of Texas Health Science Center at Houston; McGovern Medical School, Houston

80113

CenExel Rocky Mountain Clinical Research, LLC, Englewood

84132

University of Utah Clinical Neurosciences Center, Salt Lake City

85013

Barrow Neurological Institute, Phoenix

89081

Universitätsklinikum Ulm; Klinik für Neurologie, Ulm

91054

Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie, Erlangen

91105

SC3 Research Group, Inc, Pasadena

94010

Hopital Henri Mondor; Service de Neurologie, Créteil

94304

Stanford Univ Medical Center, Palo Alto

95817

University of California Davis Medical System, Sacramento

98034

Evergreen Health Care Center, Kirkland

125367

Research Center of Neurology; Neurology Department #5, Moskva

420061

?linical hospital at Kazan station, Republican Center for Movement Disorders and Botulinum Therapy, Kazan'

660037

FSBHI Siberian Clinical Center of the Federal Medical and Biological Agency, Krasnoyarsk

9120000

Centro de Trastornos del Movimiento (CETRAM); CETRAM, Santiago

92037-1337

University of California San Diego, La Jolla

02215

Beth Israel Deaconess Medical Center, Boston

10032-3725

Columbia University, New York

C1221ADC

Hospital Ramos Mejía, CABA

C1192AAX

INEBA, Capital Federal

C1284AEB

Hospital Britanico de Buenos Aires, Ciudad Autonoma Buenos Aires

T6G 1Z1

University of Alberta Hospital, Edmonton

V6T 2B5

University of British Columbia Hospital; Division of Neurology, Vancouver

B3S 1N2

True North Clinical Research-Halifax, Halifax

M3B 2S7

Centre for Movement Disorders, North YORK

K1Y 4E9

Ottawa Hospital Research Institute, Ottawa

H2X 0C2

Centre Hospitalier de l?Université de Montréal (CHUM), Montreal

Unknown

Hopital Roger Salengro Service de Neurologie, Lille

A.O.U. Careggi; Diaprtimento Scienze Neurologiche e Psichiatriche, Florence

Auckland DHB - Neurlogy Department; Neurology Department, Auckland

00189

Azienda Ospedaliera Sant'Andrea; UOC Neurologia, Rome

511-0061

Kuwana City Medical Center, Mie

945-8585

National Hospital Organization Niigata National Hospital, Niigata

700-8558

Okayama University Graduate School of Medicine, Densitry and Pharmaceutical Sciences., Okayama

558-8558

Osaka General Medical Center, Osaka

187-8551

National Center of Neurology and Psychiatry, Tokyo

9713 GZ

Universitair Medisch Centrum Groningen, Groningen

2333 ZA

LUMC, Leiden

80-462

Szpital Sw. Wojciecha; Oddzial Neurologiczny, Gdansk

31-505

Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K, Krakow

02-957

Instytut Psychiatrii i Neurologii, Warsaw

06080

Hospital Universitario de Badajoz; Servicio de Neurología, Badajoz

08036

Hospital Clinic Servicio de Neurologia, Barcelona

08041

Hospital de la Santa Creu i Sant Pau; Servicio de Neurologia, Barcelona

09006

Hospital Universitario de Burgos. Servicio de Neurología, Burgos

AB25 2ZD

Aberdeen Royal Infirmary; Medical Genectics, Aberdeen

B15 2TH

Queen Elizabeth Hospital, Birmingham

CB2 0SP

Cambridge Centre for Brain Repair; Department of Clinical Nuerosciences, Addenbrookes Hospital, Cambridge

CF14 4XW

University Hospital of Wales; Division of Psychological Medicine and Clinical Neurosciences, Cardiff

G51 4TF

Queen Elizabeth University Hospital Glasgow, Glasgow

LS1 3EX

Leeds General Infirmary, Leeds

WC1N 3BG

National Hospital For Neurology and Neurosurgery, London

M13 9WL

Central Manchester University Hospitals NHS Foundation Trust; Manchester Centre for Genomic Medicine, Manchester

OX3 9DU

John Radcliffe Hospital, Oxford

S10 2JF

Royal Hallamshire Hospital, Sheffield

SO16 6YD

University Hospital Southampton NHS Foundation Trust, Southhampton

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT03761849 - A Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants With Manifest Huntington's Disease | Biotech Hunter | Biotech Hunter