OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial

NAActive, not recruitingINTERVENTIONAL
Enrollment

3,648

Participants

Timeline

Start Date

June 18, 2019

Primary Completion Date

May 30, 2024

Study Completion Date

October 31, 2024

Conditions
Stroke, AcuteAtrial Fibrillation
Interventions
DRUG

Direct oral anticoagulant (DOAC)

Any of the DOACs listed above may be used for treatment in either study arm. The DOAC will be supplied from normal hospital stock, using local hospital prescriptions.

Trial Locations (44)

SY23 1ER

Bronglais General Hospital, Hywel Dda University Health Board, Aberystwyth

BA1 3NG

Royal United Hospitals Bath NHS Foundation Trust, Bath

B15 2TH

Queen Elizabeth Hospital,University Hospitals Birmingham NHS Foundation, Birmingham

BH7 7DW

Royal Bournemouth Hospital, Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth

BD9 6RJ

Bradford Royal Infirmary, Bradford Teaching Hospitals NHS Foundation Trust, Bradford

CM1 7ET

Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Broomfield

IP33 2QZ

West Suffolk Hospital, West Suffolk NHS Foundation Trust, Bury St Edmunds

CB2 0QQ

Addenbrooke's Hospital NHS Trust, Cambridge

SA31 2AF

Glangwili General Hospita, Hywel Dda University Health Boardl, Carmarthen

KT16 0PZ

St Peter's Hospital, Ashford and St. Peter's Hospitals NHS Foundation Trust, Chertsey

DE22 3NE

Royal Derby Hospital, University Hospitals of Derby and Burton NHS Foundation Trust, Derby

EX2 5DW

Royal Devon & Exeter NHS Foundation Trust, Exeter

SA61 2PZ

Withybush General Hospital, Hywel Dda University Health Board, Haverfordwest

HP11 2TT

Wycombe Hospital, Buckinghamshire Healthcare NHS Trust, High Wycombe

PE30 4ET

Queen Elizabeth Hospital Kings Lynn NHS Trust, Kings Lynn

LE1 5WW

Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester

L7 8XP

Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool

SA14 8QF

Prince Philip Hospital, Hywel Dda University Health Board, Llanelli

E1 1FR

The Royal London Hospital, Barts Health NHS Trust, London

HA1 3UJ

Northwick Park Hospital, London North West Healthcare NHS Trust, London

NW1 2BU

University College London Hospitals NHS Foundation Trust, London

SW17 0QT

St George's University Hospitals NHS Foundation Trust, London

W6 8RF

Charing Cross Hospital, Imperial College Healthcare NHS Trust, London

LU4 0DZ

Luton and Dunstable University Hospital NHS Foundation Trust, Luton

TS4 3BW

The James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Middlesbrough

MK6 5LD

Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes

NG7 2UH

Nottingham University Hospitals NHS Trust, Nottingham

PL6 8DH

Derriford Hospital University Hospitals Plymouth NHS Trust, Plymouth

BH15 2JB

Poole Hospital NHS Foundation Trust, Poole

PR2 9HT

Royal Preston Hospital, Lancashire Teaching Hospitals, Preston

RG1 5AN

Royal Berkshire NHS Foundation Trust, Reading

M6 8HD

Salford Royal Hospital, Salford Royal NHS Foundation Trust, Salford

SP2 8BJ

Salisbury District Hospital, Salisbury NHS Foundation Trust, Salisbury

S10 2JF

Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield

SO16 6YD

University Hospital Southampton NHS Foundation Trust, Southampton

SS0 0RY

Southend University Hospital NHS Foundation Trust, Southend-on-Sea

NG17 4JL

Kings Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust, Sutton in Ashfield

SA6 6NL

Morriston Hospital, Swansea Bay University Health Board, Swansea

TQ2 7AA

Torbay Hospital, Torbay and South Devon NHS Foundation, Torquay

CH49 5PE

Arrowe Park Hospital, Wirral University Teaching Hospital NHS Foundation Trust, Upton

WD18 0HB

Watford General Hospital, West Hertfordshire Hospitals NHS Trust, Watford

SO22 5DG

Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust, Winchester

LL 13 7TD

Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, Wrexham

YO31 8HE

York Teaching Hospital NHS Foundation Trust, York

All Listed Sponsors
lead

University College, London

OTHER