220
Participants
Start Date
May 1, 2019
Primary Completion Date
January 31, 2027
Study Completion Date
December 31, 2027
Dexmedetomidine
The intervention group will obtain the pharmacological treatment during both perioperative. Pharmacological treatment in the intervention group differs solely from the patients in the control group by replacing opioids with the following non-opioid treatment:
Person-centred care (PCC)
The intervention tests non-pharmacological interventions compared to conventional treatment, supplemented by an evidenced-based Person-centred care PCC approach throughout the continuum of the perioperative and until 4 weeks after discharge. This will be part of patients in Phase 2
Esketamine
The intervention group will obtain the pharmacological treatment perioperatively. Pharmacological treatment in the intervention group differs solely from the patients in the control group by replacing opioids with the following non-opioid treatment:
Lidocaine
The intervention group will obtain the pharmacological treatment perioperatively. Pharmacological treatment in the intervention group differs solely from the patients in the control group by replacing opioids with the following non-opioid treatment.
Transcutaneous Nerve Stimulation (TENS)
The intervention group will obtain non-pharmacological treatment by TENS during the entire hospital stay (both perioperative and post-operative) until discharge.
Remifentanil
The control group receives general anesthesia with Remifentanil as the routine opioid drug during general anesthesia.
Desflurane
The patient receives general anesthesia with Desflurane as the routine volatile anesthetic during general anesthesia
Propofol
The patient receives general anesthesia with Propofol as the routine induction anaesthetic during general anesthesia
Oxycodone
The control group receives Oxycodone as the routine pain management drug post-operative.
RECRUITING
Sahlgrenska University hospital/ Östra hopsital, Gothenburg
RECRUITING
Lindesberg Hospital, Lindesberg
Göteborg University
OTHER