Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced HCC Who Have Not Received Previous Systemic Anticancer Therapy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

837

Participants

Timeline

Start Date

June 10, 2018

Primary Completion Date

March 8, 2021

Study Completion Date

December 1, 2024

Conditions
Hepatocellular Carcinoma
Interventions
DRUG

Cabozantinib

Supplied as 20-mg tablets; administered orally daily at 40 mg

DRUG

Cabozantinib

Supplied as 60-mg tablets; administered orally once daily at 60 mg

DRUG

Sorafenib

Supplied as 200-mg tablets; administered orally twice daily at 400 mg

DRUG

Atezolizumab

Supplied as 1200 mg/20 mL (60 mg/mL) in sing-dose vials; administered as an IV infusion once every 3 weeks (q3w).

Trial Locations (245)

8

Exelixis Clinical Site #170, Dublin

333

Exelixis Clinical Site #94, Taoyuan District

407

Exelixis Clinical Site #161, Taichung

500

Exelixis Clinical Site #119, Changhua

704

Exelixis Clinical Site #197, Tainan City

736

Exelixis Clinical Site #145, Tainan City

833

Exelixis Clinical Site #162, Kaohsiung City

1023

Exelixis Clinical Site #60, Grafton

1070

Exelixis Clinical Site #50, Brussels

1083

Exelixis Clinical Site #140, Budapest

1090

Exelixis Clinical Site #174, Vienna

1102

Exelixis Clinical Site #136, Quezon City

1200

Exelixis Clinical Site #65, Brussels

1605

Exelixis Clinical Site #117, Pasig

2000

Exelixis Clinical Site #220, Rosario

2010

Exelixis Clinical Site #165, Darlinghurst

2050

Exelixis Clinical Site #78, Camperdown

2145

Exelixis Clinical Site #155, Westmead

2217

Exelixis Clinical Site #126, Kogarah

2650

Exelixis Clinical Site #169, Edegem

2747

Exelixis Clinical Site #171, Kingswood

3000

Exelixis Clinical Site #188, Leuven

3010

Exelixis Clinical Site #172, Bern

3050

Exelixis Clinical Site #72, Parkville

3084

Exelixis Clinical Site #166, Heidelberg

3100

Exelixis Clinical Site #137, Sankt Pölten

3128

Exelixis Clinical Site #107, Box Hill

4000

Exelixis Clinical Site #102, Liège

4010

Exelixis Clinical Site #64, Linz

4031

Exelixis Clinical Site #115, Basel

4032

Exelixis Clinical Site #25, Debrecen

4120

Exelixis Clinical Site #142, Greenslopes

6000

Exelixis Clinical Site #69, Batumi

Exelixis Clinical Site #118, Cebu City

6009

Exelixis Clinical Site #190, Nedlands

6021

Exelixis Clinical Site #62, Newton

6720

Exelixis Clinical Site #26, Szeged

7100

Exelixis Clinical Site #57, Haine-Saint-Paul

8036

Exelixis Clinical Site #198, Graz

8091

Exelixis Clinical Site #61, Zurich

9000

Exelixis Clinical Site #148, Ghent

9007

Exelixis Clinical Site #110, Sankt Gallen

9020

Exelixis Clinical Site #150, Klagenfurt

10002

Exelixis Clinical Site #82, Taipei

10126

Exelixis Clinical Site #177, Torino

10128

Exelixis Clinical Site #182, Torino

10330

Exelixis Clinical Site #96, Pathum Wan

10408

Exelixis Clinical Site #157, Goyang-si

10491

Exelixis Clinical Site #128, Taipei

11217

Exelixisi Clinical Site #100, Taipei

13125

Exelixis Clinical Site #214, Berlin

14033

Exelixis Clinical Site #29, Caen

16499

Exelixis Clinical Site #127, Suwon

19107

Exelixis Clinical Site #88, Philadelphia

20007

Exelixis Clinical Site #58, Washington D.C.

20089

Exelixis Clinical Site #53, Rozzano

20122

Exelixis Clinical Site #147, Milan

20246

Exelixis Clinical Site #215, Hamburg

21202

Exelixis Clinical Site #6, Baltimore

22030

Exelixis Clinical Site #173, Edirne

22332

Exelixis Clinical Site #75, Incheon

25030

Exelixis Clinical Site #27, Besançon

25124

Exelixis Clinical Site #152, Brescia

25250

Exelixis Clinical Site #31, Montbéliard

28007

Exelixis Clinical Site #164, Madrid

28046

Exelixis Clinical Site #63, Madrid

28100

Exelixis Clinical Site #131, Novara

28222

Exelixis Clinical Site #21, Majadahonda

Exelixis Clinical Site #22, Majadahonda

29038

Exelixis Clinical Site #141, Tuxtla Gutiérrez

29425

Exelixis Clinical Site #144, Charleston

30318

Exelixis Clinical Site #4, Atlanta

31008

Exelixis Clinical Site #59, Pamplona

33100

Exelixis Clinical Site #243, Udine

33125

Exelixis Clinical Site #191, Miami

33604

Exelixis Clinical Site #20, Pessac

34098

Exelixis Clinical Site #189, Istanbul

34125

Exelixis Clinical Site #210, Kassel

34214

Exelixis Clinical Site #179, Istanbul

34295

Exelixis Clinical Site #49, Montpellier

37000

Exelixis Clinical Site #135, León

38043

Exelixis Clinical Site #23, Grenoble

39008

Exelixis Clinical Site #28, Santander

40002

Exelixis Clinical Site #183, Khon Kaen

40138

Exelixis Clinical Site #158, Bologna

43614

Exelixis Clinical Site #39, Toledo

44093

Exelixis Clinical Site #47, Nantes

44280

Exelixis Clinical Site #180, Malatya

46009

Exelixis Clinical Site #168, Valencia

47392

Exelixis Clinical Site #77, Busan

49102

Exelixis Clinical Site #122, Dnipro

49201

Exelixis Clinical Site #86, Busan

49241

Exelixis Clinical Site #114, Busan

50009

Exelixis Clinical Site #45, Zaragoza

50200

Exelixis Clinical Site #143, Chiang Mai

54511

Exelixis Clinical Site #32, Vandœuvre-lès-Nancy

58013

Exelixis Clinical Site #125, Chernivtsi

59037

Exelixis Clinical Site #55, Lille

60590

Exelixis Clinical Site #244, Frankfurt am Main

60612

Exelixis Clinical Site #195, Chicago

60637

Exelixis Clinical Site #120, Chicago

61070

Exelixis Clinical Site #123, Kharkiv

63110

Exelixis Clinical Site #8, St Louis

64000

Exelixis Clinical Site #132, Monterrey

64128

Exelixis Clinical Site #11, Kansas City

64131

Exelixis Clinical Site #5, Kansas City

65055

Exelixis Clinical Site #124, Odesa

69317

Exelixis Clinical Site #16, Lyon

73039

Exelixis Clinical Site #163, Tricase

75246

Exelixis Clinical Site #199, Dallas

76508

Exelixis Clinical Site #19, Temple

77030

Exelixis Clinical Site #154, Houston

78250

Exelixis Clinical Site #134, San Luis Potosí City

80054

Exelixis Clinical Site #43, Amiens

80131

Exelixis Clinical Site #149, Napoli

85004

Exelixis Clinical Site #208, Phoenix

85719

Exelixis Clinical Site #159, Tucson

87131

Exelixis Clinical Site #76, Albuquerque

88000

Exelixis Clinical Site #138, Uzhhorod

89169

Exelixis Clinical Site #1, Las Vegas

90033

Exelixis Clinical Site #112, Los Angeles

90110

Exelixis Clinical Site #139, Hat Yai

92037

Exelixis Clinical Site #44, La Jolla

92093

Exelixis Clinical Site #207, San Diego

92110

Exelixis Clinical Site #48, Clichy

92377

Exelixis Clinical Site #2, Rialto

93140

Exelixis Clinical Site #56, Bondy

94115

Exelixis Clinical Site #109, San Francisco

94158

Exelixis Clinical Site #54, San Francisco

94300

Exelixis Clinical Site #153, Veracruz

97213

Exelixis Clinical Site #176, Portland

98101

Exelixis Clinical Site #13, Seattle

98109

Exelixis Clinical Site #46, Seattle

99208

Exelixis Clinical Site #3, Spokane

100034

Exelixis Site #239, Beijing

100050

Exelixis Clinical Site #237, Beijing

110006

Exelixis Clinical Site #236, Shenyang

115478

Exelixis Clinical Site #108, Moscow

130012

Exelixis Clinical Site #246, Changchun

130021

Exelixis Clinical Site #229, Changchun

150081

Exelixis Clinical Site #227, Harbin

169610

Exelixis Clinical Site #106, Singapore

183047

Exelixis Clinical Site #101, Murmansk

197758

Exelixis Clinical Site #111, Saint Petersburg

Exelixis Clinical Site #90, Saint Petersburg

200001

Exelixis Site #240, Shanghai

201305

Exelixis Clinical Site #232, Shanghai

210002

Exelixis Clinical Site #185, Nanjing

214400

Exelixis Clinical Site #234, Jiangyin

217562

Exelixis Clinical Site #97, Singapore

230002

Exelixis Clinical Site #130, Montería

230036

Exelixis Clinical Site #233, Hefei

248007

Exelixis Clinical Site #81, Kaluga

276000

Exelixis Clinical Site #226, Linyi

305524

Exelixis Clinical Site #74, Kislino

308433

Exelixis Clinical Site #116, Singapore

310016

Exelixis Clinical Site #218, Hangzhou

310022

Exelixis Clinical Site #223, Hangzhou

330006

Exelixis Clinical Site #221, Nanchang

Exelixis Clinical Site #238, Nanchang

350014

Exelixis Clinical Site #228, Fuzhou

350040

Exelixis Clinical Site #95, Krasnodar

354057

Exelixis Clinical Site #73, Sochi

361004

Exelixis Clinical Site #225, Xiamen

400015

Exelixis Clinical Site #204, Cluj-Napoca

Exelixis Clinical Site #211, Cluj-Napoca

400641

Exelixis Clinical Site #202, Cluj-Napoca

410008

Exelixis Clinical Site #231, Changsha

410013

Exelixis Clinical Site #224, Changsha

Exelixis Site #241, Changsha

450008

Exelixis Clinical Site #230, Zhengzhou

510280

Exelixis Clinical Site #242, Guangzhou

603137

Exelixis Clinical Site #80, Nizhny Novgorod

610041

Exelixis Clinical Site #235, Chengdu

700483

Exelixis Clinical Site #209, Iași

4941492

Exelixis Clinical Site #33, Petah Tikva

5262101

Exelixis Clinical Site #40, Ramat Gan

7661041

Exelixis Clinical Site #35, Rehovot

9112001

Exelixis Clinical Site #30, Jerusalem

92868-3201

Exelixis Clinical Site #200, Orange

01805

Exelixis Clinical Site #7, Burlington

08903

Exelixis Clinical Site #14, New Brunswick

27599-7600

Exelixis Clinical Site #12, Chapel Hill

C1118AAT

Exelixis Clinical Site #217, City of Buenos Aires

C1199ABB

Exelixis Clinical Site #213, City of Buenos Aires

C1264AAA

Exelixis Clinical Site #216, City of Buenos Aires

B1629ODT

Exelixis Clinical Site #219, Pilar

S2000CVB

Exelixis Clinical Site #201, Rosario

Unknown

Exelixis Clinical Site #17, Kurralta Park

Exelixis Clinical Site #146, Hong Kong

Exelixis Clinical Site #42, Hong Kong

Exelixis Clinical Site #9, Hong Kong

40110-060

Exelixis Clinical Site #184, Salvador

30110-022

Exelixis Clinical Site #89, Belo Horizonte

30130-090

Exelixis Clinical Site #98, Belo Horizonte

81520-060

Exelixis Clinical Site #113, Curitiba

90050-170

Exelixis Clinical Site #203, Porto Alegre

14784-400

Exelixis Clinical Site #175, Barretos

17210-120

Exelixis Clinical Site #121, Jaú

01246-900

Exelixis Clinical Site #186, São Paulo

01321-001

Exelixis Clinical Site #156, São Paulo

01509-010

Exelixis Clinical Site #187, São Paulo

04538-132

Exelixis Clinical Site #181, São Paulo

04543-000

Exelixis Clinical Site #91, São Paulo

T2N 4N2

Exelixis Clinical Site #71, Calgary

T6G 2B7

Exelixis Clinical Site #205, Edmonton

R3E 0V9

Exelixis Clinical Site #34, Winnipeg

B3H 2Y9

Exelixis Clinical Site #222, Halifax

L8V 5C2

Exelixis Clinical Site #194, Hamilton

K1H 8L6

Exelixis Clinical Site #212, Ottawa

H3T 1E2

Exelixis Clinical Site #85, Montreal

500 05

Exelixis Clinical Site #18, Hradec Králové

779 00

Exelixis Clinical Site #37, Olomouc

140 59

Exelixis Clinical Site #10, Prague

150 06

Exelixis Clinical Site #38, Prague

06202

Exelixis Clinical Site #51, Nice

0112

Exelixis Clinical Site #66, Tbilisi

0114

Exelixis Clinical Site #68, Tbilisi

0144

Exelixis Clinical Site #67, Tbilisi

0186

Exelixis Clinical Site #70, Tbilisi

00168

Exelixis Clinical Site #167, Roma

06700

Exelixis Clinical Site #133, Mexico City

06760

Exelixis Clinical Site #160, Mexico City

6229 HX

Exelixis Clinical Site #92, Maastricht

1105 AZ

Exelixis Clinical Site #52, Amsterdam

3015 GD

Exelixis Clinical Site #84, Rotterdam

3584 CX

Exelixis Clinical Site #36, Utrecht

02-507

Exelixis Clinical Site #41, Warsaw

80-952

Exelixis Clinical Site #24, Gdansk

41-400

Exelixis Clinical Site #15, Mysłowice

022328

Exelixis Clinical Site #206, Bucharest

03080

Exelixis Clinical Site #104, Seoul

Exelixis Clinical Site #105, Seoul

05505

Exelixis Clinical Site #99, Seoul

06273

Exelixis Clinical Site #79, Seoul

06351

Exelixis Clinical Site #93, Seoul

08908

Exelixis Clinical Site #103, Barcelona

06010

Exelixis Clinical Site #193, Ankara

06230

Exelixis Clinical Site #178, Ankara

BS2 8ED

Exelixis Clinical Site #83, Bristol

CB2 0QQ

Exelixis Clinical Site #87, Cambridge

NW3 2QG

Exelixis Clinical Site #151, London

W12 0HS

Exelixis Clinical Site #129, London

M20 4BX

Exelixis Clinical Site #192, Manchester

BT9 7AB

Exelixis Clinical Site #196, Belfast

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Exelixis

INDUSTRY

NCT03755791 - Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Subjects With Advanced HCC Who Have Not Received Previous Systemic Anticancer Therapy | Biotech Hunter | Biotech Hunter