Trazodone/Gabapentin Fixed Dose Combination Products in Painful Diabetic Neuropathy

PHASE2CompletedINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

November 22, 2018

Primary Completion Date

June 6, 2020

Study Completion Date

June 6, 2020

Conditions
Painful Diabetic Neuropathy
Interventions
DRUG

trazodone/gabapentin 2.5/25 mg

The total daily doses administered will be trazodone 7,5 mg and gabapentin 75 mg.

DRUG

trazodone/gabapentin 5/50 mg

The total daily doses administered will be trazodone 15 mg and gabapentin 150 mg.

DRUG

trazodone/gabapentin 10/100

The total daily doses administered will be trazodone 30 mg and gabapentin 300 mg.

DRUG

Gabapentin

"The total daily doses administered will be:~* 600 mg from day 0 to day 6 (±1)~* 900 mg from day 7 (±1) to day 13 (±1)~* 1200 mg from day 14 (±1) to day 20 (±1)~* 1800 mg from day 21 (±1) to day 56 (±2)"

DRUG

Placebo oral capsule

Two capsules, three times a day, for 8 weeks.

Trial Locations (30)

Unknown

Neurosanatio s.r.o., Litomyšl, 570 01

Cerebrovaskulární poradna, s.r.o., Ostrava - Poruba, 70800

Nemocnice Pardubického kraje a.s. Pardubická nemocnice Neurologická klinika, Pardubice, 532 03

Diabetologická ambulance Milan Kvapil s.r.o., Praha 4, 149 00

Axon Clinical s.r.o, Praha 5, 15000

FORBELI s.r.o., Praha 6, 160 00

Clintrial s.r.o., Praha, 100 00

Fondation Hôtel Dieu Groupe SOS Service de Diabétologie, Le Creusot

GHR MSA - Hôpital Emile Muller Service de Diabétologie-Endocrinologie-Nutrition, Mulhouse

CHU de Nantes - Hôpital Guillaume-et-René-Laënnec Clinique d'Endocrinologie, maladies métaboliques et nutrition CIC Endocrino - Nutrition - UF 7015, Nantes Cedex 144 093

Centre de Recherche Clinique G.H.M les Portes du Sud Departement d'Endocrinologie, Vénissieux

Centrum Badań Klinicznych PI-House, Gdansk, 80-546

Silmedic Sp. z o.o., Katowice, 40-282

Pro Familia Altera Poradnia Wielospecjalistyczna, Katowice, 40-648

Medyczne Centrum Diabetologiczno-Endokrynologiczno-Metaboliczne DIAB-ENDO-MET, Kraków, 31-261

NZOZ Neuromed M. i M. Nastaj Sp. P., Lublin, 20-064

Instytut Medycyny Wsi im. Witolda Chodźki Klinika Diabetologii, Lublin, 20-090

Centrum Medyczne HCP Sp. z o.o., Poznań, 61-485

RCMed Oddział Sochaczew, Sochaczew, 96-500

Nasz Lekarz Przychodnie Medyczne, Toruń, 87-100

Medycyna Kliniczna, Warszawa, 00-874

Instytut Diabetologii, Warszawa, 04-736

WroMedica I. Bielicka, A. Strzałkowska s.c., Wrocław, 51- 685

Centrum Badań Klinicznych Ośrodek Badań Wczesnej Fazy, Wrocław, 51-162

Medical Innovation Development and Research Unit (MIDRU) Heartlands Hospital, Birmingham

Diabetes Centre Wythenshawe Hospital, Manchester

Manchester Clinical Research Facility Manchester Royal Infirmary, Manchester

Diabetes Centre George Eliot Hospital NHS Trust, Nuneaton

Lancashire Clinical Research Facility The Avondale Unit Royal Preston Hospital, Preston

Clinical Research Facility Royal Hallamshire Hospital, Sheffield

Sponsors
All Listed Sponsors
collaborator

Chiltern International Inc.

INDUSTRY

lead

Aziende Chimiche Riunite Angelini Francesco S.p.A

INDUSTRY