A Phase I Pilot Study of Abaloparatide + Bevacizumab in Myelodysplastic Syndromes

PHASE1CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

February 14, 2019

Primary Completion Date

April 1, 2022

Study Completion Date

June 6, 2022

Conditions
Myelodysplastic SyndromesChronic Myelomonocytic Leukemia
Interventions
DRUG

abaloparatide

In cycle 1, patients will be treated with single-agent, subcutaneous (SQ) abaloparatide at a dose of 80 mcg/day for 28 days.

DRUG

bevacizumab

In cycles 2-4 (each cycle is 28 days), patients will be treated with SQ abaloparatide at a dose of 80 mcg/day and intravenous (IV) bevacizumab 5 mg/kg on days 1 and 15.

Trial Locations (1)

14623

University of Rochester, Rochester

All Listed Sponsors
lead

University of Rochester

OTHER

NCT03746041 - A Phase I Pilot Study of Abaloparatide + Bevacizumab in Myelodysplastic Syndromes | Biotech Hunter | Biotech Hunter