NCT03744468 - Study of BGB-A425 and LBL-007 in Combination With Tislelizumab in Advanced Solid Tumors | Biotech Hunter

Enrollment

114

Participants

Timeline

Start Date

November 13, 2018

Primary Completion Date

February 6, 2025

Study Completion Date

February 6, 2025

Conditions

Locally Advanced or Metastatic Solid Tumors for Phase 1,Dose Escalation and Phase 2 Safety Lead-in, HNSCC, NSCLC and RCC Participants for Phase 2

Interventions

DRUG

BGB-A425

Humanized IgG1-variant monoclonal antibody against TIM-3

DRUG

Tislelizumab

Humanized, IgG4-variant monoclonal antibody against PD-1

DRUG

LBL-007

Human anti LAG-3 IgG4-kappa antibody

Trial Locations (42)

2170

Sydney Southwest Private Hospital, Liverpool

3000

Peter Maccallum Cancer Centre, Melbourne

3021

Western Health Sunshine Hospital, St Albans

3128

Box Hill Hospital, Box Hill

3144

Cabrini Research and Education Institute, Malvern

4215

Gold Coast University Hospital, Southport

4575

Sunshine Coast Hospital and Health Service, Birtinya

5006

Calvary North Adelaide Hospital, North Adelaide

5112

Lyell McEwin Hospital, Elizabeth Vale

6009

Hollywood Private Hospital, Nedlands

Linear Clinical Research, Nedlands

10021

Weill Cornell Medical College Newyork Presbyterian Hospital, New York

10060

Istituto Di Candiolo Irccs, Torino

14000

Centre de Lutte Contre Le Cancer Francois Baclesse, Caen

16247

The Catholic University of Korea, St Vincents Hospital, Suwon

16499

Ajou University Hospital, Suwon

19111

Fox Chase Cancer Center, Philadelphia

20133

Fondazione Irccs Istituto Nazionale Dei Tumori, Milan

21565

Gachon University Gil Medical Center, Incheon

22031

Schar Cancer Institute, Fairfax

22903

University of Virginia, Charlottesville

27514

University of North Carolina At Chapel Hill, Chapel Hill

28040

Hospital Clinico San Carlos, Madrid

28050

Hospital Universitario Hm Madrid Sanchinarro, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

33076

Centre de Lutte Contre Le Cancer Institut Bergonie, Bordeaux

40138

Irccs Azienda Ospedaliero Universitaria Bologna, Bologna

40536

University of Kentucky Markey Cancer Center, Lexington

41013

Hospital Universitario Virgen Del Rocio, Seville

44033

Ulsan University Hospital, Donggu

60637

University of Chicago Medical Center, Chicago

78229

Ut Health San Antonio Mays Cancer Center, San Antonio

80014

University of Colorado Cancer Center, Aurora

92868

Chao Family Comprehensive Cancer Center, Orange

77030-4009

The University of Texas Md Anderson Cancer Center, Houston

85-796

Centrum Onkologiiim Prof F Lukaszczyka Wbydgoszczy, Bydgoszcz

02-034

Narodowy Instytut Onkologii Im Marii Skodowskiej Curie Pastwowy Instytut Badawczy, Warsaw

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St Marys Hospital, Seoul

08908

Institut Catala Doncologia, Barcelona

08916

Ico Hug Trias I Pujol, Barcelona